Results 121 to 130 of about 6,515,199 (373)
From Nature to Engineering: Mortar Volume and Interfacial Mechanics in Bioinspired Ceramics
Advanced Engineering Materials, EarlyView.Inspired by natural armors like nacre, this study explores how varying the volume fraction of the soft mortar layer impacts the interfacial strength and toughness of bioinspired ceramics. Experimental and computational analysis reveals that higher mortar volumes increase energy dissipation but reduce interfacial stiffness, offering insights for ...
Ehsan Azad +4 more
wiley +1 more source
The Lock is the Key: Development of Novel Drugs through Receptor Based Combinatorial Chemistry
Acta Chimica Slovenica, 2017 Modern drug discovery is mainly based on the de novo synthesis of a large number of compounds with a diversity of chemical functionalities. Though the introduction of combinatorial chemistry enabled the preparation of large libraries of compounds from so-
Goran Šinko, Nikola Maraković
doaj +1 more source
Nature Chemical Biology, 2018 G-protein-coupled receptors (GPCRs) are critically involved in signal transduction. Structural views of several GPCRs have recently been obtained, but the structural principles determining subtype selectivity are still mostly elusive. Now, a combined solid-state NMR and molecular-modeling approach reveals how bradykinin GPCRs distinguish between ...
openaire +4 more sources
Solvent fluctuations induce non-Markovian kinetics in hydrophobic pocket-ligand binding
, 2016 We investigate the impact of water fluctuations on the key-lock association kinetics of a hydrophobic ligand (key) binding to a hydrophobic pocket (lock) by means of a minimalistic stochastic model system.
Dzubiella, Joachim +2 more
core +1 more source
Advanced Engineering Materials, EarlyView.Additive manufacturing technologies like laser powder‐bed fusion offer great design freedom and individualization of products down to a batch size of one. However, parts fabricated with this technology suffer from poor quality. Acoustic assistance during the build process can minimize these drawbacks.
Oliver Maurer, Dirk Bähre
wiley +1 more source
Effect of spin-lock frequency on quantitative myocardial T1ρ mapping
Insights into ImagingObjectives To use T1ρ mapping to assess myocardial fibrosis and to provide a reference for future clinical application, it is necessary to understand the factors influencing T1ρ values.
Caiyun Han +13 more
doaj +1 more source
Western Journal of Emergency Medicine, 2019 Introduction: Safe firearm storage is associated with a lower risk of firearm-related injury and death. Although providing firearm locking devices is a key component of firearm safety interventions, little is known about the types and characteristics of ...
Joseph A. Simonetti +5 more
doaj +1 more source
Bridging the Gap Between Energy and Climate Policies in Brazil: Policy Options to Reduce Energy-Related GHG Emissions [PDF]
, 2015 Brazil is facing a series of important policy decisions that will determine its energy future over the next several decades, with important implications for the country's economic competitiveness, the well-being of its citizens, and the global climate ...
Oswaldo Lucon +2 more
core
A hydrogen beam to characterize the ASACUSA antihydrogen hyperfine spectrometer
, 2018 The antihydrogen programme of the ASACUSA collaboration at the antiproton decelerator of CERN focuses on Rabi-type measurements of the ground-state hyperfine splitting of antihydrogen for a test of the combined Charge-Parity-Time symmetry.
Amsler, C. +21 more
core +1 more source
Advanced Engineering Materials, EarlyView.This study presents a 3D representative volume element‐based simulation approach to predict mesoscopic residual stress and strain fields in silicon solid solution‐strengthened ductile cast iron. By modeling phase transformation kinetics with an enhanced Johnson–Mehl–Avrami–Kolmogorov model, the effects of varying cooling rates on residual stresses are ...
Lutz Horbach +6 more
wiley +1 more source