Results 121 to 130 of about 6,742,422 (376)

The Lock is the Key: Development of Novel Drugs through Receptor Based Combinatorial Chemistry

open access: yesActa Chimica Slovenica, 2017
Modern drug discovery is mainly based on the de novo synthesis of a large number of compounds with a diversity of chemical functionalities. Though the introduction of combinatorial chemistry enabled the preparation of large libraries of compounds from so-
Goran Šinko, Nikola Maraković
doaj   +1 more source

A Plasmodium key fits a mosquito lock [PDF]

open access: bronze, 2020
Sung‐Jae Cha, Marcelo Jacobs‐Lorena
openalex   +1 more source

What Do Large Language Models Know About Materials?

open access: yesAdvanced Engineering Materials, EarlyView.
If large language models (LLMs) are to be used inside the material discovery and engineering process, they must be benchmarked for the accurateness of intrinsic material knowledge. The current work introduces 1) a reasoning process through the processing–structure–property–performance chain and 2) a tool for benchmarking knowledge of LLMs concerning ...
Adrian Ehrenhofer   +2 more
wiley   +1 more source

A Template for Implementing Fast Lock-free Trees Using HTM

open access: yes, 2017
Algorithms that use hardware transactional memory (HTM) must provide a software-only fallback path to guarantee progress. The design of the fallback path can have a profound impact on performance.
Brown T.   +4 more
core   +1 more source

Investigating the Effects of Build Height on Mechanical Behavior of Large‐Scale Laser Wire Directed Energy Deposited Nickel Titanium Alloy

open access: yesAdvanced Engineering Materials, EarlyView.
Laser wire directed energy deposition process was leveraged to fabricate large scale NiTi alloy wall. Evaluation of build‐height‐dependent tribo‐mechanical properties revealed significant differences in location specific sample characteristics. The middle region achieved optimal performance (superior wear resistance, balanced strength‐ductility ...
Hyunsuk Choi   +5 more
wiley   +1 more source

Effect of spin-lock frequency on quantitative myocardial T1ρ mapping

open access: yesInsights into Imaging
Objectives To use T1ρ mapping to assess myocardial fibrosis and to provide a reference for future clinical application, it is necessary to understand the factors influencing T1ρ values.
Caiyun Han   +13 more
doaj   +1 more source

Preferences for Firearm Locking Devices and Device Features Among Participants in a Firearm Safety Event

open access: yesWestern Journal of Emergency Medicine, 2019
Introduction: Safe firearm storage is associated with a lower risk of firearm-related injury and death. Although providing firearm locking devices is a key component of firearm safety interventions, little is known about the types and characteristics of ...
Joseph A. Simonetti   +5 more
doaj   +1 more source

Bridging the Gap Between Energy and Climate Policies in Brazil: Policy Options to Reduce Energy-Related GHG Emissions [PDF]

open access: yes, 2015
Brazil is facing a series of important policy decisions that will determine its energy future over the next several decades, with important implications for the country's economic competitiveness, the well-being of its citizens, and the global climate ...
Oswaldo Lucon   +2 more
core  

Recent Advancements in Bulk Processing of Rare‐Earth‐Free Hard Magnetic Materials and Related Multiscale Simulations

open access: yesAdvanced Engineering Materials, EarlyView.
This article provides an overview of recent advancements in bulk processing of rare‐earth‐free hard magnetic materials. It also addresses related simulation approaches at different scales. The research on rare‐earth‐free magnetic materials has increased significantly in recent years, driven by supply chain issues, environmental and social concerns, and
Daniel Scheiber, Andrea Bachmaier
wiley   +1 more source

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