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There is a lock for every key

Nature Chemical Biology, 2021
Chemoproteomics-enabled identification of the targets of a hydroxylated cholesterol metabolite, 20(S)-hydroxycholesterol, reveals it to be the first reported endogenous ligand of the sigma-2 receptor, a drug target for neurodegeneration and neuropathic pain.
Weizhi Yu, Jeremy M. Baskin
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Lock and key colloids

Nature, 2010
New functional materials can in principle be created using colloids that self-assemble into a desired structure by means of a programmable recognition and binding scheme. This idea has been explored by attaching 'programmed' DNA strands to nanometre- and micrometre- sized particles and then using DNA hybridization to direct the placement of the ...
S, Sacanna   +3 more
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Three-Dimensional Lock and Key Colloids

Journal of the American Chemical Society, 2014
Colloids with well-defined multicavities are synthesized through the hydrolytic removal of silica cluster templates from organo-silica hybrid patchy particles. The geometry of the cavities stems from the originally assembled cluster templates, displaying well-defined three-dimensional symmetries, ranging from spherical, linear, triangular, tetrahedral,
Wang, Y   +6 more
openaire   +4 more sources

Locks and keys

Biochemistry and Molecular Biology Education, 2007
AbstractAnalogies can be powerful teaching tools because they can make abstract material intelligible to students by comparing it to material with which the students are already familiar. In this study, we interviewed 43 students to determine the specific ways they use analogies to learn and function in their biochemistry classes.
Marykay, Orgill, George, Bodner
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