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Nature Chemical Biology, 2021
Chemoproteomics-enabled identification of the targets of a hydroxylated cholesterol metabolite, 20(S)-hydroxycholesterol, reveals it to be the first reported endogenous ligand of the sigma-2 receptor, a drug target for neurodegeneration and neuropathic pain.
Weizhi Yu, Jeremy M. Baskin
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Chemoproteomics-enabled identification of the targets of a hydroxylated cholesterol metabolite, 20(S)-hydroxycholesterol, reveals it to be the first reported endogenous ligand of the sigma-2 receptor, a drug target for neurodegeneration and neuropathic pain.
Weizhi Yu, Jeremy M. Baskin
openaire +2 more sources
Nature, 2010
New functional materials can in principle be created using colloids that self-assemble into a desired structure by means of a programmable recognition and binding scheme. This idea has been explored by attaching 'programmed' DNA strands to nanometre- and micrometre- sized particles and then using DNA hybridization to direct the placement of the ...
S, Sacanna +3 more
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New functional materials can in principle be created using colloids that self-assemble into a desired structure by means of a programmable recognition and binding scheme. This idea has been explored by attaching 'programmed' DNA strands to nanometre- and micrometre- sized particles and then using DNA hybridization to direct the placement of the ...
S, Sacanna +3 more
openaire +2 more sources
Three-Dimensional Lock and Key Colloids
Journal of the American Chemical Society, 2014Colloids with well-defined multicavities are synthesized through the hydrolytic removal of silica cluster templates from organo-silica hybrid patchy particles. The geometry of the cavities stems from the originally assembled cluster templates, displaying well-defined three-dimensional symmetries, ranging from spherical, linear, triangular, tetrahedral,
Wang, Y +6 more
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To lock or not to lock patients'rooms: the key to autonomy?
Psychiatric services (Washington, D.C.), 2009Many patients with schizophrenia experience prominent negative symptoms. Functional impairment often results in patients who remain in their rooms for most of the day. It has thus become common practice in many psychiatric wards to lock patients' rooms during much of the morning and afternoon hours to encourage participation in ward activities and ...
Netta, Shoenfeld +3 more
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The key to the FANCD2–FANCI lock
Nature Structural & Molecular Biology, 2022Cody M. Rogers, Patrick Sung
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SecEd, 2005
When exam papers are stolen or there are accusations of cheating, the security of Britain's exam system comes under scrutiny. Gary Ward explains how exam board Edexcel keeps its examination process secure
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When exam papers are stolen or there are accusations of cheating, the security of Britain's exam system comes under scrutiny. Gary Ward explains how exam board Edexcel keeps its examination process secure
openaire +1 more source
Can smart transportation inhibit carbon lock-in? The case of China
Transport Policy, 2023Kangyin Dong, Congyu Zhao
exaly