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Synthesis of ‘dual-key-and-lock’ drug carriers for imaging and improved drug release

Nanotechnology, 2020
In this work, a ‘dual-key-and-lock’ drug carrier was designed to respond to the tumor microenvironment (TME). A core–shell Fe-MOF@ZIF-8 was synthesized, with ZIF-8 as the shell (the first lock) to encapsulate catalase (CAT), and the Fe metal–organic ...
Haiqing Gao   +9 more
semanticscholar   +1 more source

Locks and keys to the boardroom

Gender in Management: An International Journal, 2003
This paper reports an interview study with 12 directors in a major international telecommunications company, to identify the career paths which they took to reach board level in their organisation. The aim was to ascertain whether there were gender differences in the career facilitators and barriers met en route to the top.
Susan Vinnicombe, Val Singh
openaire   +2 more sources

Best Practices: To Lock or Not to Lock Patients'Rooms: The Key to Autonomy?

Psychiatric Services, 2008
Many patients with schizophrenia experience prominent negative symptoms. Functional impairment often results in patients who remain in their rooms for most of the day. It has thus become common practice in many psychiatric wards to lock patients' rooms during much of the morning and afternoon hours to encourage participation in ward activities and ...
Anne-Marie Ulman   +3 more
openaire   +3 more sources

067 Keys and locks

Journal of Neurology, Neurosurgery & Psychiatry, 2012
This case demonstrates two uncommon conditions presenting in a single patient. A 47-year-old male with a history since childhood of generalised tonic clonic seizures, well controlled, not on anti epileptic medication for 6 years presented with frequent complex partial seizures, disorientation and deteriorating short term memory. EEG was normal however,
P M E Slade, C Lawthom
openaire   +2 more sources

Locks, keys and symbioses [PDF]

open access: possibleNature, 2003
The association between legumes and nitrogen-fixing bacteria requires molecular recognition to allow bacterial entry into root hairs. The discovery of a novel type of plant receptor clarifies how this happens.
J. Allan Downie, Martin Parniske
openaire   +1 more source

Nitric Oxide-Activated "Dual-Key-One-Lock" Nanoprobe for In Vivo Molecular Imaging and High-Specificity Cancer Therapy.

Journal of the American Chemical Society, 2019
Cancer treatments are confounded by severe toxic effects toward patients. To address this, activatable nanoprobes have been designed for specific imag-ing and destruction of cancer cells under the stimulation of specific cancer-associated biomarkers ...
Lili Teng   +8 more
semanticscholar   +1 more source

Lock-and-Key and Shape-Memory Effects in an Unconventional Synthetic Path to Magnesium Metal-Organic Frameworks.

Angewandte Chemie, 2019
We report a new magnesium metal-organic framework (MOF) (CPM-107) with a special interaction with CO2 . CPM-107 contains Mg2 -acetate chains crosslinked into a 3D net by terephthalate.
Huajun Yang   +6 more
semanticscholar   +1 more source

Locks and master keys

The Mathematical Gazette, 1988
A simple lock contains a bolt and one or more levers which are lifted the correct amount by the appropriate key, thus allowing the bolt to be moved in and out. In addition there are often circular obstructions or “wards” to stop some keys being turned in the lock.
openaire   +2 more sources

Under lock and key

SecEd, 2005
When exam papers are stolen or there are accusations of cheating, the security of Britain's exam system comes under scrutiny. Gary Ward explains how exam board Edexcel keeps its examination process secure
openaire   +2 more sources

Keys for Locks in Administrative Argument

Administration & Society, 1994
Developments in public administration are better understood as rhetorical rather than scientific in Herbert Simon's meaning. Administrative arguments succeed by using the six keys to acceptance of classical rhetoric: symmetry, metaphor, ambiguity, private interest presented as public good, selective use of information, and suspension of disbelief To ...
Michael Jackson, Christopher Hood
openaire   +2 more sources

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