Results 191 to 200 of about 1,547,847 (284)

A Canadian Advanced Physiotherapist Practitioner Shared-Care Model in Pediatric Rheumatology Offers Safe and Quality Care in the Management of Juvenile Idiopathic Arthritis-Comparing Key Performance Indicators with the PR-COIN Registry. [PDF]

Children (Basel)
Herrington J, Clarkin P, Singleton J, Beattie K, Vora SS, Banschbach K, Bingham CA, Cellucci T, Fair D, Gilbert M, Gottlieb B, Harris JG, Heale L, Lee T, Mannion ML, Oberle EJ, Pan N, Park J, Toth M, Weiss JE, Batthish M, Pediatric Rheumatology Care and Outcomes Improvement Network.   +21 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Key performance indicators for pharmaceutical services: A systematic review. [PDF]

Explor Res Clin Soc Pharm
de Souza JFF, Fernandes BD, Rotta I, Visacri MB, de Mendonça Lima T.   +4 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Key performance indicators for acute intermittent kidney replacement therapy in critically ill patients: a protocol for a systematic review. [PDF]

BMJ Open
Opgenorth D, Bialy L, Robertson K, Bowker SL, Sinnadurai S, Morrissey J, Pannu N, Klarenbach S, James M, Tolwani A, Heung M, Neyra JA, Mottes T, Hammal F, Wang X, Kung JY, Bagshaw SM, Rewa OG.   +17 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Assessing the impact of nurses' patient safety competencies on key performance indicators (KPIs) for patient safety outcomes at Tamale Teaching Hospital: the mediating role of leadership and barriers to competency development. [PDF]

BMC Health Serv Res
Ibrahim MM, Abdul-Rahaman F, Sayibu MS, Alhassan DN, Awudu RT, Sisala IM, Wuni A, Abdulai AM.   +7 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Challenges of Key Performance Indicators and Metrics for Measuring Medical Science Liaison Performance: Insights from a Global Survey. [PDF]

Pharmacy (Basel)
Dyer S, Hyder C, Kraemer J.
europepmc   +1 more source