Results 191 to 200 of about 339,817 (223)

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Key Performance Indicators Predictive of Success in Soccer: A Comprehensive Analysis of the Greek Soccer League. [PDF]

J Funct Morphol Kinesiol
Stafylidis A, Mandroukas A, Michailidis Y, Vardakis L, Metaxas I, Kyranoudis AE, Metaxas TI.   +6 more
europepmc   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Key performance indicators in pre-hospital response to disasters and mass casualty incidents: a scoping review. [PDF]

Eur J Trauma Emerg Surg
Markou-Pappas N, Lamine H, Ragazzoni L, Caviglia M.   +3 more
europepmc   +1 more source

How to Refine and Prioritize Key Performance Indicators for Digital Health Interventions: Tutorial on Using Consensus Methodology to Enable Meaningful Evaluation of Novel Digital Health Interventions. [PDF]

J Med Internet Res
McCabe C, Connolly L, Quintana Y, Weir A, Moen A, Ingvar M, McCann M, Doyle C, Hughes M, Brenner M.   +9 more
europepmc   +1 more source

Clinical pharmacy key performance indicators for hospital inpatient setting: a systematic review. [PDF]

Int J Clin Pharm
Magedanz L, Silva HL, Galato D, Fernandez-Llimos F.   +3 more
europepmc   +1 more source

Effect of COVID-19 on Key Performance Indicators of Spanish Professional Soccer League. [PDF]

J Funct Morphol Kinesiol
Fernández-Cortés J, Gómez-Carmona CD, Mancha-Triguero D, García-Rubio J, Ibáñez SJ.   +4 more
europepmc   +1 more source