Results 71 to 80 of about 7,526,383 (337)

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

open access: yesFEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer   +10 more
wiley   +1 more source

Using the method of inverse growth calculations to determine the age composition of catches for certain species of marine commercial fish

open access: yesИзвестия ТИНРО
New method for constructing size-and-age keys is proposed and tested on the data on size composition of yellowfin sole in commercial catches in the Patience Bay in 1950–2024, with the age of fish determined using the inverse growth calculations ...
A. O. Zolotov
doaj   +1 more source

The New Zealand population: A synopsis of trends and projections 1991 - 2016 [PDF]

open access: yes, 2005
Although there are many excellent documents and online resources available on New Zealand population trends, it is useful to highlight some key trends in one short document. This paper provides a synopsis of trends with respect to population size and age
Baxendine, Sandra   +4 more
core   +1 more source

Evolution of public cooperation in a monitored society with implicated punishment and within-group enforcement

open access: yes, 2015
Monitoring with implicated punishment is common in human societies to avert freeriding on common goods. But is it effective in promoting public cooperation?
Chen, Xiaojie   +2 more
core   +1 more source

Novel and unscrutinized immune entities of the zebrafish gut

open access: yesFEBS Letters, EarlyView.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil   +5 more
wiley   +1 more source

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

open access: yesFEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona   +4 more
wiley   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

open access: yesFEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Programmatic mapping and size estimation of key populations to inform HIV programming in Tanzania.

open access: yesPLoS ONE, 2020
INTRODUCTION:A programmatic mapping and size estimation study was conducted in 24 districts in 5 regions of Tanzania to estimate the size and locations of female sex workers (FSW) and men who have sex with men (MSM) to inform the HIV programming for Key ...
Mwita Wambura   +12 more
doaj   +1 more source

Illinois Immigrant Political Almanac [PDF]

open access: yes, 2008
Immigrants make up a growing part of Illinois' population. As immigrants settle in thisstate, become citizens, and register to vote, we are also playing an increasingly key role in our state's electorate.
Flavia Jimenez, Fred Tsao, Rob Paral
core  

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

open access: yesFEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker   +9 more
wiley   +1 more source

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