Results 41 to 50 of about 633 (197)
PIM2 interacts with tristetraprolin and promotes breast cancer tumorigenesis
Molecular Oncology, Volume 12, Issue 5, Page 690-704, May 2018., 2018 Tristetraprolin (TTP) is an AU‐rich element‐binding protein that regulates mRNA stability and is deregulated in some cancers. We have found that the oncogene Proviral Insertion in Murine Lymphomas 2 (PIM2) binds to TTP and decreases TTP protein levels by targeting it for degradation via the ubiquitin‐proteasome pathway.
Chune Ren +9 more
wiley +1 more source
مطالعات تطبیقی فقه و اصول مذاهب, 2023 Some Sunni jurists have made jurisprudential use of the historians' reports in the Sirah books (books about infallible’s life). While the Jaʿfari (Imamiyya) jurists do not want to infer to historical sources in their jurisprudence inference.
Saeed Nazaritavakkoli +2 more
doaj +1 more source
Hallmarks of cancer and AU‐rich elements
WIREs RNA, Volume 8, Issue 1, January/February 2017., 2017 Post‐transcriptional control of gene expression is aberrant in cancer cells. Sustained stabilization and enhanced translation of specific mRNAs are features of tumor cells. AU‐rich elements (AREs), cis‐acting mRNA decay determinants, play a major role in the posttranscriptional regulation of many genes involved in cancer processes.
Khalid S. A. Khabar
wiley +1 more source
Journal of the Association for Information Science and Technology, Volume 76, Issue 1, Page 216-237, January 2025.Abstract Research on how people look for and interact with information has a long history in the information field. The current literature has been repeatedly reviewed in earlier volumes of Annual Review of Information Science and Technology. In this review, we offer an overview of the research published in this area in the years 2016–2022 with a focus
Isto Huvila, Tim Gorichanaz
wiley +1 more source
The Journal of Pathology, Volume 230, Issue 1, Page 28-38, May 2013., 2013 Abstract The activities of RNA‐binding proteins are perturbed in several pathological conditions, including cancer. These proteins include tristetraprolin (TTP, ZFP36) and HuR (ELAVL1), which respectively promote the decay or stability of adenylate‐uridylate‐rich (AU‐rich) mRNAs.
Wijdan Al‐Ahmadi +3 more
wiley +1 more source
Immunology, Volume 173, Issue 3, Page 511-519, November 2024.Understanding the underlying mechanisms of the increased abundance of inflammatory cytokines during disease, including those situations where double‐stranded RNA is involved, such as during viral and autoimmune diseases, is key to developing effective treatments. We identified here that the dsRNA, a viral and autoimmune mimic, caused increased p38‐MAPK
Edward G. Hitti +4 more
wiley +1 more source
NAQD IBN TAIMIYAH LIL-QADHI ABDEL JABBAR FI RU'YATILLAH TA'ALA
Jurnal Al-Dustur, 2021 permasalahan melihat Allah adalah permasalahan yang sudah ada sejak permulaan masa Mu’tazilah dan masa Ahmad bin Hanbal. Permasalahan tersebut terus berlanjut sampai masa Al-Qadhi Abdul Jabbar dan Ibnu Taimiyyah.
Muhammad Wahyudi
doaj +1 more source
Characterization of mRNA therapeutics
Mass Spectrometry Reviews, Volume 43, Issue 5, Page 1066-1090, September/October 2024.Abstract Therapeutic messenger RNAs (mRNAs) have emerged as powerful tools in the treatment of complex diseases, especially for conditions that lack efficacious treatment. The successful application of this modality can be attributed to its ability to encode entire proteins.
Guilherme J. Guimaraes +2 more
wiley +1 more source
Traffic, Volume 25, Issue 9, September 2024.ABSTRACT Limited nutrient availability in the tumor microenvironment can cause the rewiring of signaling and metabolic networks to confer cancer cells with survival advantages. We show here that the limitation of glucose, glutamine and serum from the culture medium resulted in the survival of a population of cancer cells with high viability and ...
Aliye Ezgi Güleç Taşkıran +12 more
wiley +1 more source
Digital media preferences: in the focus of social research
Хабаршы Журналистика сериясы, 2020 This research presents the results of a sociological study on the media behaviour of the adult population of Kazakhstan viewers of TV «Khabar» in the context of the issue of worldview orientations in the digital age.
Султанбаева Г.С. +3 more
doaj +1 more source