Results 221 to 230 of about 867,159 (238)

EBV‐Driven ODC1 Upregulation Enhances Polyamine Anabolism to Promote Viral Replication and Cisplatin Resistance in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
EBV‑BZLF1 initiates ODC1‑driven polyamine anabolism that correlates with poor clinical prognosis in nasopharyngeal carcinoma. The ODC1–spermidine axis promotes viral replication, cell proliferation and innate immune evasion. Pharmacological inhibition of ODC1 rescues cisplatin sensitivity, establishing ODC1 as a viable therapeutic target for EBV ...
Yueshuo Li, Xudong Hu, Chenxing Yang, Na Liu, Lin Wang, Xi Cai, Min Tang, Ya Cao, Li Shang, Feng Shi   +9 more
wiley   +1 more source

Primary tumor-derived lactate primes prostate cancer cells for a dormant fate. [PDF]

Sci Adv
Ippolito L, Pranzini E, Gangarossa G, Iozzo M, Comito G, Venditti G, Roccabianca S, Pardella E, Lulli M, Santi A, Nesi G, Giannoni E, Chiarugi P.   +12 more
europepmc   +1 more source

Lactobacillus‐Loaded Bioadhesive Hydrogel with Prolonged Retention and Microenvironmental Remodeling for Endometrial Repair and Fertility Restoration

Advanced Science, EarlyView.
A bioactive adhesive hydrogel capable of long‐term uterine retention (>14 days) and local microenvironment modulation is developed by straightforward integration of α‐lipoic acid, L‐arginine, tannic acid, and Lactobacillus johnsonii, which can markedly enhance endometrial repair and restore fertility in a rat model of endometrial injury.
Lifa Chen, Hui Zhou, Yifei Li, Yi Liang, Yifan Zhang, Huiyu Huang, Qiuxian Xie, Youchen Tang, Huixia Ye, Yu Zhang   +9 more
wiley   +1 more source

Artificial Grain Boundaries Created by Freestanding Membrane Transfer Reveal Angle‐Dependent Ferroelectric Switching and Leakage in BaTiO3

Advanced Science, EarlyView.
Artificial grain boundaries are created in BaTiO3$\text{BaTiO}_3$ thin films by freestanding membrane transfer, enabling direct isolation of a single boundary. Local ferroelectric switching and leakage are found to concentrate at the grain boundary, while increasing misorientation systematically enhances conduction.
Shin‐Rou Yin, Yu‐Hsin Lin, Yun‐Guan Wei, Yu‐Cheng Fang, Yung‐Chi Su, Yu‐Wei Chen, Yu‐Ting Lin, Chia‐Chun Wei, Chih‐Hung Wu, Ching‐Yu Chiang, Heng‐Jui Liu, Jan‐Chi Yang, Yi‐Chun Chen, Yen‐Lin Huang   +13 more
wiley   +1 more source

Iodine concentrations in human milk after maternal high therapeutic potassium iodide dosing during breastfeeding: a contribution from the ConcePTION project. [PDF]

Ther Adv Endocrinol Metab
Van Neste M, Krutsch K, Ceulemans M, Demaegdt H, Cheyns K, Nauwelaerts N, Annaert P, Smits A, Allegaert K.   +8 more
europepmc   +1 more source

An Intravesical Akkermansia muciniphila‐Based Chemo‐Immunotherapeutic Platform for Bladder Cancer

Advanced Science, EarlyView.
Pasteurized Akkermansia muciniphila is engineered into an intravesical F127/doxorubicin platform that couples localized chemotherapy with immune remodeling. By inducing apoptosis, ferroptosis, and immunogenic cell death, this chemo‐immunotherapeutic system enhances dendritic‐cell maturation, antigen cross‐presentation, and tumor‐specific CD8+ T‐cell ...
Rongkang Li, Anguo Zhao, Qi Zhuang, Lei Peng, Rui Liang, Jiadong Zhao, Yang Liu, Dashi Deng, Peng Yu, Xiqi Peng, Shaohua Zhang, Song Wu   +11 more
wiley   +1 more source

Integrative Cross-platform Analysis of Kinase Inhibitor Effects on Statin-relevant Cardioprotective Pathways in Human Cardiomyocytes. [PDF]

Cancer Genomics Proteomics
Kuo TY, Cheng MC, Jhou HJ, Lee CH, Chen PH.   +4 more
europepmc   +1 more source

A Micropeptide Component of the OGDH Complex Modulates ATP Production in the TCA Cycle

Advanced Science, EarlyView.
This study identified a mitochondrial micropeptide encoded by a non‐canonical open reading frame (alt‐ORF) within the CTSB gene. This micropeptide named APPM (ATP production‐promoting micropeptide) is a novel component of the OGDHc complex in the TCA cycle. APPM localizes to the inner mitochondrial membrane and directly binds to OGDH, the E1 subunit of
Xinqiang Yin, Weiyan Qi, Lifen Lin, Huilin Zheng, Guoxiang Zhao, Quan Chen, Guoqiang Shao, Yifan Wu, Jialiang Hu, Hanmei Xu   +9 more
wiley   +1 more source