Results 151 to 160 of about 867,159 (238)

KI als strategische Ressource für Produkte etablieren

Im vorliegenden Whitepaper wird ein leichtgewichtiges Verfahren, das »Vier-Phasen-Modell« vorgestellt, dass dabei unterstützt, KI als strategische Ressource und Werkzeug für Unternehmen verfügbar zu machen.
Kett, Holger Joachim, Le, Nguyen-Truong, Renner, Niclas, Kutzias, Damian   +3 more
core   +1 more source

Nonreciprocal Swarmalators With Reconfigurable and Controllable Formations for Robot Collectives

Advanced Robotics Research, EarlyView.
Nonreciprocal swarmalator interactions are enabled through control barrier functions to transform self‐organizing robot collectives into reconfigurable, constraint‐aware systems. Complex two‐ and three‐dimensional shapes, continuous morphing, obstacle‐aware navigation, collective splitting, and object transport emerge from modulating agent‐level ...
Kush Patel, Xinyue Xu, Wei Xiao, Steven Ceron   +3 more
wiley   +1 more source

Genetic and Pharmacologic Inhibition of Myostatin Restores Muscle Mass in a Dynamin 2-Related Centronuclear Myopathy Mouse Model. [PDF]

J Cachexia Sarcopenia Muscle
Anne-Cécile D, David A, Mathias V, Valentine A, Chloé P, Quentin D, Esra K, Sidney C, Emmanuelle G, Louise C, Alexandre G, Josiane C, Aja P, Maximilien B, Baptiste M, Christophe H, Schaeffer L, Olli R, Marc B, Rémi M, Damien F.   +20 more
europepmc   +1 more source

Chemical Screening Identifies Danofloxacin as a Self‐Renewal Agonist of Embryonic Stem Cells through Alleviation of HDAC1‐Mediated Deacetylation of Tert and Prdm10

Advanced Science, EarlyView.
This study identified Danofloxacin as a novel supporter of the maintenance of mouse embryonic stem cell (ESC) pluripotency. It functions partially by inhibiting HDAC1, which increases specific histone acetylation marks and activates key genes like Tert and Prdm10.
Yan Zhang, Junxiang Ji, Baoxing Dong, Zhenhua Zhu, Xucheng Lv, Peng Chen, Wenqiang Liu, Min Zhou, Shou‐Dong Ye   +8 more
wiley   +1 more source

Prohibitin-1 cysteine-69 plays a sex-dependent role in fatty acid metabolism. [PDF]

J Lipid Res
Bernier KJ, Gao Z, Bhatia Y, Dehkordi NB, Nasiri F, Daquinag AC, Pasqualini R, Arap W, Kolonin MG, Mishra S.   +9 more
europepmc   +1 more source

Der St.Galler KI-Kompetenzrahmen als Orientierung für Hochschullehre

Es gibt inzwischen zahlreiche Modelle und Frameworks zu KI-Kompetenzen, die jedoch oft sehr breit angelegt sind und damit nur begrenzt Orientierung für konkrete Bildungsbereiche bieten. Der St.
Bass, Steve, Schallert-Vallaster, Stefanie, Buchner, Josef   +2 more
core  

Coixenolide Enhances Antitumor Immunity of Cytotoxic CD8+ T Cells by Inhibiting S100A8/A9‐CD36 Axis in Obesity‐Associated Pancreatic Adenocarcinoma

Advanced Science, EarlyView.
Pancreatic adenocarcinoma (PAAD) remains highly lethal with limited treatment options. This study demonstrates that coixenolide, a bioactive compound from Coix lacryma‐jobi L. and a key component of the clinically approved Kanglaite injection, exhibits enhanced antitumor efficacy in high‐fat diet (HFD)‐induced obese mice bearing PAAD tumors compared to
Kaidi Chen, Rong Chen, Wei Li, Bin Song, Ruiying Zhang, Lewei Dai, Yuwei Qi, Ruqian Chen, Yifan Xu, Hangbin Li, Jingyi Huang, Fangping Wu, Jianan Peng, Xinyu Wang, Yang Xiong, Chaofeng Mu, Guilin Cheng, Zhaoshen Li, Shanming Ruan, Lei Huang, Mancang Gu   +20 more
wiley   +1 more source

Fit für die KI-Transformation

1213Die rasante Entwicklung der Künstlichen Intelligenz stellt die Arbeitswelt vor globale Herausforderungen. Angepackt werden müssen diese aber im Kleinen. Matthias Peissner vom Fraunhofer IA0 zeigt, wie ein wünschenswerter KI-Einsatz gelingen kann, wie
Peissner, Matthias
core   +1 more source

Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis

Advanced Science, EarlyView.
Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang, Jianhua Li, Huilu Zhang, Qi Qin, Yichen Huang, Xiaofan Tian, Chao Sun, Binbin Li, Zhengxin Wang, Xin Zhang   +9 more
wiley   +1 more source

Skeletal muscle fatigue resistance is differentially affected in 8-month-old male and female hAβ-KI mice. [PDF]

Physiol Rep
Copeland EN, Melekh E, Fajardo VA, MacPherson REK.   +3 more
europepmc   +1 more source