Results 41 to 50 of about 867,159 (238)

Von Kühlschranklichtern, KI-Pubertät und Turnschuhen. Thomas Metzinger im Gespräch mit Karsten Wendland. Transkript zum Podcast [PDF]

, 2021
Für den Philosophen Prof. Dr. Thomas Metzinger von der Universität Mainz ist es keineswegs ausgeschlossen, dass Künstliche Intelligenz irgendwann Bewusstsein haben könnte.
Lahn, Nadine, Wendland, Karsten, Vetter, Pascal   +2 more
core   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

Die Gründerväter der KI machten sich über Bewusstsein keine Gedanken. Christian Vater im Gespräch mit Karsten Wendland. Transkript zum Podcast [PDF]

, 2021
Für den Technikhistoriker Christian Vater, der in Heidelberg und Karlsruhe forscht, hat Forschung zu KI archäologische Qualitäten. Er gräbt Fundstü-cke aus, die unser heutiges Verständnis von KI prägen, auch wenn sie zu ihrer Zeit anders gemeint waren ...
Lahn, Nadine, Wendland, Karsten, Vetter, Pascal   +2 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Increased rates of unattained developmental milestones among Israeli children between 2016 and 2020: a national report

Israel Journal of Health Policy Research, 2023
Background The early years of children’s lives are critical for their healthy development. Although children’s growth and development rates may vary, a significant delay during early childhood could indicate a medical or a developmental disorder ...
Irena Girshovitz, Guy Amit, Inbal Goldshtein, Deena R. Zimmerman, Ravit Baruch, Pinchas Akiva, Meytal Avgil Tsadok, Yair Sadaka   +7 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

smartCasaplus – ein risikobasiertes geriatrisches Gesundheitscoaching für multimorbide Versicherte

Monitor Versorgungsforschung
Das geriatrische Schulungsprogramm Casaplus der MedicalContact AG bietet bereits seit 2007 telefonische Gesundheitscoachings für multimorbide geriatrische Versicherte, von dem bereits ca. 30.000 Versicherte profitiert haben.
Stephan Burger, Markus M. Müller, Thomas P. Zahn   +2 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Variability and estimating in fruiting of shea tree (Vitellaria paradoxa C.F. Gaertn) associated to climatic conditions in West Africa: implications for sustainable management and development

Plant Production Science, 2019
Shea tree (Vitellaria paradoxa) is one of the main native oil plants with high economic value in Africa. Its fruits are used for food, medicinal, cultural and exportation purposes. However, the lack of efficient tools to assess annual fruit production of
Loyapin Bondé, Oumarou Ouédraogo, Issaka Ouédraogo, Adjima Thiombiano, Joseph I. Boussim   +4 more
doaj   +1 more source

Queere KI: Zum Coming-out smarter Maschinen [PDF]

, 2022
Gängige Formen von Diskriminierung sowie die Reproduktion normativer Stereotype sind auch bei künstlicher Intelligenz an der Tagesordnung. Die Beitragenden erläutern Möglichkeiten der Reduktion dieser fehlerhaften Verfahrensweisen und verhandeln die ...
Junker, Carsten, Félix, Valérie
core   +1 more source