Results 161 to 170 of about 715,372 (292)

Dim light at night impacts circadian rhythms and Alzheimer's disease-like neuroinflammation and neuropathology in humanized APP SAA knock-in mice. [PDF]

Sleep
Duncan MJ, Hawkins MR, Bytyqi L, Whitlock HR, Shepard SM, Cox MF, Drinkard EG, Macheda T, Roberts KN, Kohler K, Schmidt MC, Johnson CE, Sunderam S, O'Hara BF, Murphy MP, Bachstetter AD.   +15 more
europepmc   +1 more source

Empra-KI

2023/2024 - Der Einsatz von KI im Projektseminar (Empra) eines B.Sc. Psychologie als Mittel gegen Überforderung und für den Aufbau von Selbstvertrauen in die eigenen R-Fähigkeiten The use of AI in the research lab of a B.Sc. Psychology as a means against
Philip Kennedy, Daniela Feistauer
core   +1 more source

A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity

Advanced Science, EarlyView.
This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu, Xinyu Sun, Wanxia Ma, Jianming Yang, Xuan Sun, Lisong Zhang, Yumeng Liu, Tianshu Ren, Qi Wang, Jingyu Wang, Xiao Li, Xianping Peng, Liu Yang, Junqiang Lv, Zhi Yao, Zhi‐Song Zhang, Quan Wang   +16 more
wiley   +1 more source

KI und Haftung · KI-Versicherungen · Verbotene Praktiken laut KI-Verordnung

Risiko, Versicherung, Haftung – wichtige Themen, die aktuell im Zusammenhang mit Künstlicher Intelligenz diskutiert werden. Außerdem: Wie teuer es für Unternehmen werden kann, wenn sie gegen die KI-Verordnung der EU verstoßen. Der monatliche Newsletter "prompt/" aus dem iRights.Lab bringt relevante KI-Neuigkeiten auf den Punkt und ordnet sie ein.
openaire   +2 more sources

Expression of Phosphomimetic OSTM1-T328E/S329D Variant Partially Restores Bone Resorption Defect in LRRK1-Deficient Mice. [PDF]

Biology (Basel)
Udayakumar A, Chen Y, Zhao H, Mohan S, Xing W.   +4 more
europepmc   +1 more source

Covalent Inhibition of SHMT2 by Gambogic Acid Induces Ferroptosis Through Mitochondrial Collapse in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
In this study, chemoproteomics combined with genetic and functional analyses was integrated to identify SHMT2 as a covalent and functional target of gambogic acid (GA) in triple‐negative breast cancer (TNBC). Further validation demonstrated that GA selectively modifies the Cys241 site of SHMT2, triggering mitochondrial dysfunction, activating the Nrf2 ...
Tong Yang, Chong Qiu, Yulei Li, Ying Zhang, Chen Wang, Jie Zhou, Zheng Chu, Ang Ma, Ling Huang, Yin Kwan Wong, Junzhe Zhang, Peng Gao, Cui Liu, Junhua Zhang, Huan Tang, Jigang Wang   +15 more
wiley   +1 more source

A case report of thyroid-like low-grade nasopharyngeal papillary adenocarcinoma with literature review. [PDF]

Front Oncol
Kong D, Yang M, Deng X, Xu Z, Duan H, Pan G, Lei Z.   +6 more
europepmc   +1 more source

Regulierung generativer Künstlicher Intelligenz in der KI-VO

Keine andere KI-basierte Technologie hat in den letzten Jahren – seit Einführung von ChatGPT im November 2022 – für so viel Aufmerksamkeit gesorgt wie generative KI (generative AI; GenAI), allen voran große Sprachmodelle (Large Language Models, LLMs).Das
Ebers, Martin,
core  

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

Reduction in hippocampal cholinergic neurostimulating peptide enhances memory impairment in App^NL-G-F KI mice. [PDF]

Alzheimers Dement
Tsuda Y, Madokoro Y, Suzuki K, Ooba T, Sato T, Uchida Y, Nagai-Arakawa I, Saito T, Hara H, Hida H, Matsukawa N.   +10 more
europepmc   +1 more source