Results 21 to 30 of about 775,408 (293)

The prognostic and predictive potential of Ki-67 in triple-negative breast cancer

Scientific Reports, 2020
As a cell proliferation biomarker, Ki-67 is principally used in ER+/HER2− breast cancer. However, the importance and the best cutoff point of Ki-67 in triple-negative breast cancer (TNBC) remains unclear and was evaluated in this study.A total of 1800 ...
Xiuzhi Zhu, Li Chen, Binhao Huang, Yue Wang, Lei Ji, Jiong Wu, G. Di, Guangyu Liu, Keda Yu, Z. Shao, Zhonghua Wang   +10 more
semanticscholar   +1 more source

To Ki or Not to Ki: Re-Evaluating the Use and Potentials of Ki-67 for T Cell Analysis [PDF]

Frontiers in Immunology, 2021
This study discusses substantive advances in T cell proliferation analysis, with the aim to provoke a re-evaluation of the generally-held view that Ki-67 is a reliable proliferation markerper se, and to offer a more sensitive and effective method for T cell cycle analysis, with informative examples in mouse and human settings.
Francesca Di Rosa, Andrea Cossarizza, Andrea Cossarizza, Adrian C. Hayday, Adrian C. Hayday, Adrian C. Hayday   +5 more
openaire   +6 more sources

Carriage of mutations R462Q (rs 486907) and D541E (rs 627928) of the RNASEL gene and risk factors in patients with prostate cancer in Burkina Faso

BMC Medical Genomics, 2022
Background Prostate cancer (Pca) is a public health problem that affects men, usually of middle age or older. It is the second most common cancer diagnosed in men and the fifth leading cause of death.
Essonan Kadanga, Abdou Azaque Zouré, Théodora M. Zohoncon, Lassina Traoré, Bienvenu Désiré Ky, Albert Théophane Yonli, Djé Djénèba Aïda Traoré, Bapio Valery Jean Télesphore Elvira Bazié, Herman Karim Sombié, Pegdwendé Abel Sorgho, Sessi Frida Appoline Tovo, Kalifou Traoré, Teega-Wendé Clarisse Ouedraogo, Florencia W. Djigma, Jacques Simpore   +14 more
doaj   +1 more source

Ki-67: more than a proliferation marker

Chromosoma, 2018
Ki-67 protein has been widely used as a proliferation marker for human tumor cells for decades. In recent studies, multiple molecular functions of this large protein have become better understood. Ki-67 has roles in both interphase and mitotic cells, and
Xiaoming Sun, P. Kaufman
semanticscholar   +1 more source

An Analysis of Factors Associated with Drug Use in Schools in The City of Ouagadougou in 2019

International Journal of Multidisciplinary Educational Research and Innovation, 2023
Faced with this situation, a general awareness has led to the creation of an international day against drug abuse and trafficking on June 26. Several international and regional conventions are working together to develop strategies and policies to fight ...
Cheick B. El F. Baga, Ludmila Akoyi, Hermine Tognon, Constant Paré Boyo, Jill Johns, Toé S. A. Josué, Nicolas Meda   +6 more
doaj   +1 more source

Effect of Ki-67 Expression Levels and Histological Grade on Breast Cancer Early Relapse in Patients with Different Immunohistochemical-based Subtypes

Scientific Reports, 2020
This retrospective analysis evaluated the interaction between Ki-67 and histological grade and their prognostic role in different breast cancer subtypes.
Qingmo Liang, D. Ma, Runfang Gao, Keda Yu   +3 more
semanticscholar   +1 more source

Validation of the Remote Automated ki:e Speech Biomarker for Cognition in Mild Cognitive Impairment: Verification and Validation following DiME V3 Framework

Digital Biomarkers, 2022
Introduction: Progressive cognitive decline is the cardinal behavioral symptom in most dementia-causing diseases such as Alzheimer’s disease. While most well-established measures for cognition might not fit tomorrow’s decentralized remote clinical trials,
Johannes Tröger, Ebru Baykara, Jian Zhao, Daphne ter Huurne, Nina Possemis, Elisa Mallick, Simona Schäfer, Louisa Schwed, Mario Mina, Nicklas Linz, Inez Ramakers, Craig Ritchie   +11 more
doaj   +1 more source

Agentivité reproductive, utilisation de la contraception et expérience des rapports sexuels non souhaités chez les femmes burkinabè [PDF]

Pensées Genre, Penser Autrement
Cette étude analyse les liens entre l’agentivité reproductive des femmes et deux résultats de santé reproductive au Burkina Faso : l’utilisation d’une méthode contraceptive moderne et l’expérience de rapports sexuels non souhaités.
Fiacre BAZIE, Yentéma ONADJA, Abdramane B. SOURA , Georges GUIELLA   +3 more
doaj   +1 more source

Ki-67 acts as a biological surfactant to disperse mitotic chromosomes

Nature, 2016
Eukaryotic genomes are partitioned into chromosomes that form compact and spatially well-separated mechanical bodies during mitosis. This enables chromosomes to move independently of each other for segregation of precisely one copy of the genome to each ...
Sara Cuylen, C. Blaukopf, A. Politi, T. Müller-Reichert, B. Neumann, I. Poser, J. Ellenberg, A. Hyman, D. Gerlich   +8 more
semanticscholar   +1 more source

Tau hyperphosphorylation correlates with reduced methylation of protein phosphatase 2A

Neurobiology of Disease, 2008
The down-regulation of protein phosphatase 2A (PP2A) activity is thought to play an important role in the formation of tau hyperphosphorylation in the Alzheimer's disease (AD) brain. Methylation of the PP2A catalytic subunit at the L309 site can potently
Xin-Wen Zhou, Jan-Åke Gustafsson, Heikki Tanila, Cecilia Bjorkdahl, Rong Liu, Bengt Winblad, Jin-Jing Pei   +6 more
doaj   +1 more source