Results 51 to 60 of about 834,123 (280)

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Engagement politique des femmes et logiques d’incorporation dans les instances de décision dans la ville de Ouagadougou (Burkina Faso) [PDF]

Pensées Genre, Penser Autrement, 2022
La participation effective des femmes à la vie politique burkinabè est faible et stagnante. Cependant, une catégorie de femmes engagées sont parvenues à tirer leur épingle du jeu.
Sophie Wenninkonté KABRE, Bowendsom Claudine Valérie ROUAMBA/OUEDRAOGO   +1 more
doaj  

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Sustainable Au (III) adsorption using greenly Fe-BTC/PpPDA synthesized composite: kinetic and isothermal studiesSustainable Au (III) adsorption using greenly Fe-BTC/PpPDA synthesized composite: kinetic and isothermal studies [PDF]

Royal Society Open Science
A novel porous composite material, Fe-BTC/PpPDA, was synthesized via a green solvothermal route by integrating polyparaphenylenediamine (PpPDA) into the Fe-BTC metal–organic framework.
Woulou Somda, Francis O. Konate, Konan R. Koffi, Gerard Y. Sanou, Rafiatou Lingane, Isaï N. Bombiri, Mohamed Khalid, Arsène H. Yonli   +7 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

La caricature des démocraties africaines avant et après la baule dans le parachutage et en attendant le vote des bêtes sauvages. [PDF]

Pensées Genre, Penser Autrement, 2022
Cette réflexion porte sur la présence d’éléments de l’histoire politique de l’Afrique francophone dans la fiction romanesque. Par le truchement de la colonisation, l’Afrique occidentale française (AOF) a épousé des valeurs de son ancien maitre ...
Boulkini COULDIATI, Fatimata NOMBRE
doaj  

KI-LOK - Prüfverfahren für KI-basierte Komponenten im Eisenbahnbetrieb

Bestehende Verifikations- und Validierungsmethoden für KI-Systeme stoßen insbesondere bei sicherheitskritischen Anwendungen an ihre Grenzen, da sie die spezifischen Herausforderungen von Black-Box-Modellen und kontinuierlich lernenden Systemen ...
Knoblauch, Dorian, Beiker, Henry, Viehmann, Johannes, Großmann, Jürgen, Kharma, Sami   +4 more
core   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source