Results 181 to 190 of about 833,353 (279)

Reply to Dal, Z.; Erkan, M. Comment on "Lai et al. Liver Transplantation for the Cure of Neuroendocrine Liver Metastasis: A Systematic Review with Particular Attention to the Risk Factors of Death and Recurrence. <i>Biomedicines</i> 2024, <i>12</i>, 2419". [PDF]

Biomedicines
Lai Q, Coppola A, Mrzljak A, Cigrovski Berkovic M.   +3 more
europepmc   +1 more source

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source

Predictive Contribution of p16 Beyond HPV Genotype in the Histopathologic Detection of CIN2+ Lesions: A Real-World Cervical Biopsy Cohort Study. [PDF]

Diagnostics (Basel)
Güner Özen E, Özen S, Tanyeri D, Tanyeri U, Sancı M.   +4 more
europepmc   +1 more source

Copper‐Driven Epithelial Barrier Disruption: A Novel Mechanism of COPD Acute Exacerbations Mediated by the TNF‐α/ATP7A Axis

Advanced Science, EarlyView.
This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xinru Xiao, Yongzhe Hao, Ziqi Ding, Zhipeng Wang, Yujia Shi, Yanhua Huang, Chunjian Qi, Qian Zhang   +7 more
wiley   +1 more source

A cetacean-specific CNE suppresses osteogenesis to drive appendicular modification in secondary aquatic adaptation. [PDF]

iScience
Liu Y, Zhang Z, Zhang F, Xu S, Yang G.
europepmc   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Triple Organ Transplantation in the United States After the 2018 Heart Allocation Policy Implementation. [PDF]

JACC Adv
Alam A, Low Y, Francis J, Golombeck D, Goldberg R, Reyentovich A, Gentry S, Massie A, Moazami N, Katz JN.   +9 more
europepmc   +1 more source

Regulierung generativer Künstlicher Intelligenz in der KI-VO

Keine andere KI-basierte Technologie hat in den letzten Jahren – seit Einführung von ChatGPT im November 2022 – für so viel Aufmerksamkeit gesorgt wie generative KI (generative AI; GenAI), allen voran große Sprachmodelle (Large Language Models, LLMs).Das
Ebers, Martin,
core  

Integrative Multi‐Omics Analysis Reveals a Mitochondrial–Immune Axis Associated With Neoadjuvant Chemotherapy Response in High‐Grade Serous Ovarian Cancer

Advanced Science, EarlyView.
Integrative multi‐omics analysis delineates a mitochondrial–immune axis governing neoadjuvant chemotherapy response in high‐grade serous ovarian cancer. Immune‐active tumors exhibit enhanced B‐cell infiltration and favorable sensitivity, whereas metabolically rewired tumors display oxidative phosphorylation dependency and resistance.
Wei Jiang, Yi Wang, Xiaohang Lu, Qianlan Yao, Libing Xiang, Xu Cai, Xiaoyu Tu, Shaoxian Tang, Ying Xu, Yufan Cheng, Liming Shen, Huijuan Yang   +11 more
wiley   +1 more source

Metabolic regulation of calcium homeostasis via SERCA succination. [PDF]

Sci Adv
Ham SJ, Kim Y, Kim S, Bang S, Koh YH, Roh SH, Park HS, Chung J.   +7 more
europepmc   +1 more source