Results 231 to 240 of about 831,855 (280)

Alpha protein kinase 3 gene therapy restores heart function in mouse and human models of cardiomyopathy. [PDF]

Nat Cardiovasc Res
McNamara JW, Keen EB, Sutton R, She Y, Huckstep H, Le LHH, Mehdiabadi NR, Venkatesh MS, Griffen B, Mills RJ, Theodoris CV, Hudson JE, Titmarsh DM, Humphrey SJ, Porrello ER, Elliott DA.   +15 more
europepmc   +1 more source

UBE2O Drives Immune Evasion and Radioimmunotherapy Resistance in Lung Cancer by Degrading CDKL1 to Induce PD‐L1 Transcription

Advanced Science, EarlyView.
UBE2O targets CDKL1 for the degradation to upregulate PD‐L1 expression and promotes resistance to radioimmunotherapy in lung cancer, supporting the potential of targeting UBE2O as a promising therapeutic strategy. ABSTRACT Resistance to radioimmunotherapy is one of the primary causes of treatment failure in lung cancer patients; however, the underlying
Huichan Xue, Xiaohua Jie, Zhiwei Liu, Ruoxin Fang, Shuo Wu, Xiaorong Dong, Shuangbing Xu   +6 more
wiley   +1 more source

Integrating Digital Ki-67 Labeling Index and K-TIRADS for Malignancy Risk Stratification in Thyroid Core Needle Biopsies. [PDF]

Cancers (Basel)
Cha Y, Kim SY, Kim C, Bae JS, Lim DJ, Jung SL, Jung CK.   +6 more
europepmc   +1 more source

Noh Performance of Hachi no ki, 1931

core  

AI‐Assisted Digital Single‐Molecule Activity Tracker for Decoupling Intrinsic Heterogeneity from Photo‐Oxidative Damage in High‐Photon‐Flux Enzymology

Advanced Science, EarlyView.
Employing a digital single‐molecule activity tracker (dSMAT), this research demonstrates that high‐photon‐flux irradiation drives progressive oxidative scarring in polymerases. Unlike simple thermal denaturation, real‐time kinetic tracking dynamically visualizes enzymes degrading into multiple impaired subpopulations.
Anran Zheng, Qi Yang, Jinze Li, Fuqiang Ma, Xuefeng Wang, Zhen Guo, Chuanyu Li, Dongshu Li, Jia Yao, Zhiqi Zhang, Wei Zhang, Lianqun Zhou   +11 more
wiley   +1 more source

Correlation of quantitative background parenchymal enhancement with prognostic factors in breast cancer. [PDF]

Front Oncol
Liu Y, Yu W, Wu Z, Shen Y, Lin B, Huang G, Wu Z, Yu X.   +7 more
europepmc   +1 more source

A Metal‐Phenolic Nanocluster Orchestrates Mito‐Ca2+ Metabolic Autonomy for Tumor Ca2+ Interference Therapy

Advanced Science, EarlyView.
Tumor Ca2+ interference therapy suffers from self‐protective Ca2+ metabolic autoregulation. In this scenario, a versatile metal‐phenolic nanocluster (TCMH) is engineered to modulate mitochondrial calcium uniporter (MCU) ‐mediated mito‐Ca2+ metabolic autonomy.
Ronglong Chen, Jia Huang, Yuepeng Wang, Shucong Yao, Fei Wu, Juan Liu, Chunxue Song, Li Lin, Xijun Lin, Yingjie Deng, Chao Zhang, Zhiquan Huang, Zixian Huang, Lisi Xie   +13 more
wiley   +1 more source

Efficacy of surufatinib in advanced Grade 3 neuroendocrine tumors: a real-world, national, multicenter study. [PDF]

Ther Adv Med Oncol
Wang J, Zhang N, Liang Y, Long J, Chi Y, Zhang S, Bai C, Wang Y, Wu Y, Hu H, Hu W, Huang L, Liu Y, Lv H, Song S, Suo A, Wang X, Zhang L, Zhu L, Chen J, Hao J.   +20 more
europepmc   +1 more source

Clinicopathological Features, Tumor Localization and Treatment Outcomes in Paraganglioma: A Single-Center Medical Oncology Cohort. [PDF]

Diagnostics (Basel)
Asoglu H, Asarkaya E, Aykut A, Cavusoglu GD, Aydinalp Camadan Y, Kolsuz Turker I, Demirkose H, Koseci T, Bayram E, Akkus G, Asoglu R, Erdogan S, Kara IO.   +12 more
europepmc   +1 more source

Study on the predictive efficacy of Ki-67, ER, and PR levels on the effectiveness of neoadjuvant chemotherapy in breast cancer. [PDF]

Front Med (Lausanne)
Lin L, Han B.
europepmc   +1 more source