Results 191 to 200 of about 2,547,482 (267)

Modulus‐Switchable Miniature Robots for Biomedical Applications: A Review

Advanced Robotics Research, EarlyView.
Materials, robot designs, proof‐of‐concept functions, and biomedical applications of modulus‐switchable miniature robots. Miniature soft robots have shown great potential in biomedical applications due to their excellent controllability and suitable mechanical properties in biological environments.
Chunyun Wei, Yibin Wang, Jiangfan Yu
wiley   +1 more source

Pulmonary mixed squamous cell and glandular papilloma in the elderly: a case report and literature review. [PDF]

Front Oncol
Zhang P, Wang Y, Huang C, Ji Y, Han X.
europepmc   +1 more source

TRIM47 Regulates Energy Metabolism via Glycolytic Reprogramming to Drive Hepatocellular Carcinoma Progression and Represents an Efficient Therapeutic Target

Advanced Science, EarlyView.
This study identifies TRIM47 as a key driver of liver cancer progression by promoting glycolysis through ubiquitin‐mediated degradation of the gluconeogenic enzyme FBP1. TRIM47 enhances glucose uptake, lactate and ATP production, and tumor growth and metastasis.
Weijie Sun, Yihang Yuan, Qian Qiu, Kexuan Tan, Xutong Li, Haotian Li, Luyang Kang, Yuting Gu, Ziheng Zhang, Jiayu He, Jiali Li, Junjie Lin, Zihan Xie, Kexing Han, Jiabin Li, Yang Zhang, Ting Wu, Yufeng Gao   +17 more
wiley   +1 more source

Ampullary Neuroendocrine Tumors: Multicenter Experience and Emerging Perspectives on Endoscopic Treatment. [PDF]

Rambam Maimonides Med J
Fimiano F, Dioscoridi L, Stegagnini M, Forti E, Pugliese F, Cintolo M, Bonato G, Bravo M, Palermo A, Gallo C, Binda C, Zulli C, Zaccari P, Mariani A, Gabbrielli A, Arcidiacono PG, Mutignani M.   +16 more
europepmc   +1 more source

Disengaging the Engine: Histone Deacetylases 1 and 2‐Mediated Acetylation of Hexokinase‐2 Regulates Energy Metabolism in Microglia Following Intracerebral Hemorrhage

Advanced Science, EarlyView.
This study demonstrates that HDAC1/2 knockout in microglia alleviates neurological deficits, preserves white matter, and accelerates hematoma clearance after ICH. HDAC1/2 inhibition reduces HK2 acetylation, shifts metabolism from glycolysis to fatty acid oxidation, reduces inflammation, and enhances phagocytosis.
Zhiwen Jiang, Heng Yang, Xinjie Gao, Zengyu Zhang, Ruiyuan Weng, Yuchao Fei, Jiabin Su, Hanqiang Jiang, Wei Ni, Yuxiang Gu   +9 more
wiley   +1 more source

Kidney injury risk in congenital solitary functioning kidney: the role of nephron mass assessed by serum uromodulin and the rs4293393 T > C polymorphism. [PDF]

BMC Res Notes
Guarino S, Tirelli P, Di Sessa A, Braile M, Maisto F, Gizzone P, Palma PL, Miraglia Del Giudice E, Cirillo G, Marzuillo P.   +9 more
europepmc   +1 more source

NNMT Orchestrates Metabolic‐Epigenetic Reprogramming to Drive Macrophage‐Myofibroblast Transition in Hypertrophic Scarring

Advanced Science, EarlyView.
In macrophage‐myofibroblast transition, upregulated NNMT depletes S‐Adenosylmethionine‌ (SAM) and nicotinamide adenine dinucleotide(NAD+), thereby triggering epigenetic reprogramming via Histone H3 Lysine 27 acetylation (H3K27ac) accumulation at the promoter region of master transcription factor Prrx1.
Xiwen Dong, Weinan Guo, Yuxuan Qian, Wenyan Jin, Xiaozhen Li, Jingyuan Yang, Qingrong Ni, Shuang Wu, Fanni Li, Hua Wang, Chunying Li, Hong Cai   +11 more
wiley   +1 more source

Continuous-time random walk diffusion MRI facilitates assessment of Ki-67 expression in endometrial cancer: a comparative study with diffusion kurtosis imaging. [PDF]

BMC Cancer
Liu W, Ren J, Li Z, Liu W, Wang S, Ba Y, Jiang B, Han D, Yan R.   +8 more
europepmc   +1 more source

Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors

Advanced Science, EarlyView.
Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen, Scott R Walsh, Li Deng, Lan Chen, Yonghong Wan   +4 more
wiley   +1 more source

Comparative Performance of Flow Cytometry and ELISA for Detecting Ki-67 and HLA-DR in Whole Blood: Implications for Tuberculosis Diagnosis and Treatment Monitoring.

J Pharm Bioallied Sci
Dangi JS, Pandey M, Jain AK, Pandey R, Singh MP, Pandey S.   +5 more
europepmc   +1 more source