Results 191 to 200 of about 2,560,491 (267)

Targeting m6A Reader YTHDF1 Enhances Antitumor Immunity and Potentiates Anti‐PD‐L1 Efficacy in Intrahepatic Cholangiocarcinoma

Advanced Science, EarlyView.
The m6A reader YTHDF1 drives intrahepatic cholangiocarcinoma (ICC) progression by remodeling the tumor immune microenvironment. YTHDF1 promotes MDSC recruitment via activation of m6A‐FOSL2‐CXCL6/CXCR2 axis, thereby suppressing CD8+ T cell infiltration and function.
Li Luo, Ziqin Liu, Zimin Song, Dong Zhang, Cong Liang, Fei Fang, Kai Lei, Lina Wang, Weikang Chen, Shunli Shen, Ming Kuang, Xiaoxing Li, Jun Yu, Shiyan Wang, Lixia Xu   +14 more
wiley   +1 more source

Double Staining Immunohistochemistry and Digital Pathology: Moving Towards Standardization of the Proliferative Index Evaluation in Meningiomas. [PDF]

J Pers Med
Fabbri VP, Broggi G, Attolini G, L'Imperio V, Pagni F, Guerriero A, Marletta S, Fiorentino F, Caramaschi S, Malagoli C, Eccher A, Caltabiano R.   +11 more
europepmc   +1 more source

KIS [PDF]

, 2019
openaire   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Resolving the renal microenvironment: a 5-plex immunofluorescence workflow to quantify B-lineage cells in FFPE lupus nephritis biopsies. [PDF]

Front Immunol
Chan C, Chang PS, Chalasani S, Tao J, Raghu H, Austin CD.   +5 more
europepmc   +1 more source

Integrating Spatial Proteogenomics in Cancer Research

Advanced Science, EarlyView.
Xx xx. ABSTRACT Background: Spatial proteogenomics marks a paradigm shift in oncology by integrating molecular analysis with spatial information from both spatial proteomics and other data modalities (e.g., spatial transcriptomics), thereby unveiling tumor heterogeneity and dynamic changes in the microenvironment.
Yida Wang, Yang Wu, Feng Zhang, Parthiban Periasamy, Haiyue You, Denise Goh, Rachel Elizabeth Ann Fincham, Xin Ning, Danping Wu, Lu Liu, Ying Jiang, Zhiwen Qian, Joe Yeong, Yan Zhang   +13 more
wiley   +1 more source

Iodine Content of Commercially Available Iodized Salts in Hungary Determined by Iodometric Titration: Implications for the Effectiveness of Salt Iodization. [PDF]

Nutrients
Hunter N, Berényi K, Csergő Á, Zand A, Bufa A, Dörnyei Á, Németh B, Kiss I, Árvay B, Szendi K.   +9 more
europepmc   +1 more source

Ki Lal ? Ki Lal? in Spanish

Translation Today, 2019
openaire   +1 more source

CD28‐Targeted Enzyme‐Responsive Conformation‐Switching Peptide Self‐Assembly for Selective T‐Cell Acute Lymphoblastic Leukemia (T‐ALL) Therapy

Advanced Science, EarlyView.
We developed the enzyme‐responsive peptide SAp‐CD28 to selectively target CD28‐overexpressing T‐ALL cells. Following phosphatase‐mediated activation, SAp‐CD28 undergoes conformational switching and nanooligomerization, resulting in the disruption of CD28 downstream signaling.
Jun Li, Ziyu Jia, Dekun Li, Zhi‐Wen Hu, Yinghao Ding, Shengyi Zhang, Shengkun Tuo, Zhimou Yang, Huisheng Fu, Ling Wang, Man‐Di Wang   +10 more
wiley   +1 more source

Development and validation of a multiparameter prognostic model for extranodal natural killer/T-cell lymphoma: Integration of clinical, pathological, and molecular biomarkers. [PDF]

Cytojournal
Wu S, Liu Y, Jiang L, An L, Zhang Y, Pan Y, Song L, Wang Y, Yu G.   +8 more
europepmc   +1 more source