Results 51 to 60 of about 13,595,196 (243)
Genome-wide association and functional follow-up reveals new loci for kidney function [PDF]
, 2012 Chronic kidney disease (CKD) is an important public health problem with a genetic component. We performed genome-wide association studies in up to 130,600 European ancestry participants overall, and stratified for key CKD risk factors. We uncovered 6 new Döring, Angela, Atkinson, Elizabeth J, Gary C Curhan, Wichmann HE, Thun, G.-A., Trompet, S., Heid, I. M., Goessling Wolfram, Kroemer H.K., Boerwinkle, E., Kähönen M., Wilson J.F., Franke A., Biffar Reiner, Palmer, C., Zemunik T, Toshiko Tanaka, Rettig Rainer, Rao, Madhumathi, Toniolo, D. (Daniela), Smith, AV, Liu C.-T., Harshal Deshmukh, Curhan, G. C., Foster, Meredith C, Taliun, D, Heid Iris M., Gao, XY, Ridker P., Glazer, N., Fox Caroline S., Liu, Ching-Ti, Struchalin, M.V. (Maksim), Trompet, S. (Stella), O´Connell, J.R., Böger C.A., Chu, A.Y., de Andrade M, Smith AV, Fuchsberger Christian, Krämer, B.K., Hwang, S. J., Atkinson, Elizabeth J., Igl, W., Harris, T.B. (Tamara), Jingzhong Ding, Turner ST, Vollenweider Peter, Voelker, Uwe, Adrienne Tin (160761), Toniolo, D, J. Wouter Jukema (127361), Johnson, A.D. (Andrew), Vincent Chouraki, Uitterlinden A.G., Gorski, M. (Mathias), Adam M, Andrews JS, Rivadeneira, F, Turner, S. T., Wheeler, H.E., Gyllensten, Ulf,, Turner, ST, Rao M, Henry Völzke (64286), Meredith C. Foster (165430), Tin, A., Florian Kronenberg (87557), Andrews, J.S. (Jeanette), Nikopensius, Tiit, Shuldiner AR, Rudan, I. (Igor), Jie Jin Wang (103779), Borecki, I, Freedman, BI, Portas L, Ulivi, S, Nauck, Matthias, et al., Rao Madhumathi, Smith, A.V. (Albert Vernon), Stumvoll Michael, Ketkar S, Imboden, Medea, Peter P. Pramstaller (150111), Trompet S., Gudny Eiriksdottir (8872), Doney, A., Hastie N., Karlhans Endlich, Illig T, Vitart, Veronique, Homuth, G. (Georg), Rao M., Johansson, Åsa,, Kolcic, I. (Ivana), O'Seaghdha, Conall, Kähönen, M., Ketkar, S, Cavalieri, M., Probst-Hensch, NM, Wright, A.F., Gao, X., Deshmukh H, Minelli, Cosetta, Gasparini P., Chu, AY, Ciullo, M., Conall M O'Seaghdha, Ulf Gyllensten, Li, M. (Man), Probst-Hensch, Nicole M., Paulweber, B, Wild, S.H. (Sarah), Robino, A, Atkinson EJ, Rettig R, Buckley, B.M., Dehghan A, Johansson, Å, Illig, T., Yang, Q., Franke, Andre, Wang, J.J. (Jie Jin), Adam M., Biffar R., Colhoun, H., Cornelis MC, Curhan GC, Kolcic Ivana, Thun, G.A., Borecki I, Ding, JZ (Jing Zhong), Tönjes A., Tönjes, A. (Anke), Ding Jingzhong, Iris M Heid, Völzke, H, Kim, SK, Lohman K, Kroemer, H. K., Thun, G. A., Liu, CT, Hofman A, Köttgen, Anna, Qiong Yang, Ferrucci Luigi, Adam Martin, Boban, M., Wright, AF, Aulchenko, Y.S., Mariza de Andrade (31845), Holliday, E.G., Zaboli, G, Ding, Jingzhong, Albert V Smith, Bernhard Paulweber, Probst-Hensch Nicole M., Florian Ernst, Nick Hastie, Luigi Ferrucci (150038), Endlich Karlhans, Stumvoll, M. (Michael), Nicole M Probst-Hensch, Polasek, Ozren, Matthias Nauck, Stuart K. Kim (112150), De Andrade, M, Andrews, Jeanette S., van Duijn, Cornelia M., Anna Köttgen, Ciullo, M, Kao, WHL, Karlhans Endlich (112716), Garnaas Maija, Trompet, Stella, Palmer, Colin; id_orcid, Murgia, Federico, Struchalin, M., Gibson, G., Thor Aspelund, Ozren Polasek (3965693), Chen, M.H., Ching-Ti Liu, Pramstaller, PP, Hwang Shih-Jen, Rettig R., Vollenweider, P, Wilmar Igl, Oostra Ben A., Kovacs P, Afshin Parsa (175121), Coresh, J., Kutalik, Z. (Zoltán), Esko, T. (Tõnu), Fuchsberger, C., Pirastu, M, Cornelis, Marilyn C, Pistis, G, Chouraki, V. (Vincent), Tanaka, T, Haun M., Struchalin Maksim, Thun GA, Mägi, R., Mitchell, Braxton D., Demirkan, A, Köttgen, A., Colhoun H, Deshmukh, H., Liu Y., Launer, L. J., Garnaas M., Heid, I.M. (Iris), Andrade, M. de, Franke, A., Biffar, R., Chasman, D.I. (Daniel), Gyllensten Ulf, Campbell, Harry, Teumer, A. (Alexander), Goessling, W, Man Li (81239), Colin Palmer (165015), Liu, C. T., Ellinghaus, D., Wichmann H.-E., Wang JJ, Feitosa, M.F. (Mary Furlan), Jacqueline C. M. Witteman (175109), Bochud, M., Andrews, J. S., Bergmann, S, Tin Adrienne, O'Seaghdha C.M., Parsa, A., Goessling W, Döring Angela, Li G., Uitterlinden Andre G., Thun G.-A., Hu, Frank B., Portas, Laura, Gorski M, Chasman, DI, Georg Homuth (110202), Kardia, S.L.R., Kronenberg F, Holliday, E. G., Pistis, G. (Giorgio), Fox, C.S., Vilmundur Gudnason, Mitchell, Paul, Freedman Barry I., Doering, Angela, Ruggiero D., Wild S.H., Li, M., Ivana Kolcic, Chu, Audrey Yu-lei, Wilson, J.F., Imboden M, Goessling, W. (Wolfram), Raitakari, O., van Duijn CM, Wolfgang Koenig, Marie Metzger (156894), Chen M.-H., Launer Lenore J., Li M., Ding, J.Z., Schmidt, H., Mladen Boban, Ghazal Zaboli (174959), Ernst, F, Jacobs, Gunnar, Wichmann, HE, Isaacs, A., Kardia, Sharon L. R., Stracke, Sylvia, Trompet Stella, Stuart K Kim, Boban, Mladen, Koenig, W. (Wolfgang), Hwang, S.J., Wilson, James F; id_orcid, Nicole Glazer, Kim S.K., Feitosa M., Kovacs, P, Bergmann, S., Völker, U., Jukema J. Wouter, Rettig, R. (Rainer), Teumer, Alexander, Wright Alan F., Demirkan, A. (Ayşe), Ciullo Marina, Toshiko Tanaka (174638), Illig, T, Cavalieri M., Ming-Huei Chen, Bochud M., Aulchenko, Yurii S., Ute Nöthlings (140098), Toniolo Daniela, Nauck Matthias, Prokopenko, I, Giorgio Pistis, Böger CA, Struchalin, M, Schmidt, R. (Reinhold), Gian-Andri Thun, Kao WH, Hayward C, Colhoun Helen, Paul Mitchell (103717), Guo Li (174860), Cinzia Sala (74631), Siscovick D.S., Kardia, S.L., Gasparini, Paolo, Gudnason Vilmundur, Fox, Caroline, Giulianini F., Kovacs, Peter, Laura Portas (175069), Jacobs G, Parsa, A. (Afshin), Chen Ming-Huei, Reedik Mägi, Hayward, Caroline, Hofman, A. (Albert), Lehtimäki T, Viikari Jorma, Abbas Dehghan (174878), Albert Hofman, Igl, Wilmar, Daniel Taliun, Wild, S. H., Aspelund Thor, Ford, I., Nauck M., CARDIoGRAM Consortium, Kroemer, H.K., Hu Frank B., Heid I.M., Wheeler H.E., O'Seaghdha, Conall M, Coresh, J, Nick Hastie (175020), Tin, Adrienne, Mitchell, P, Schmidt, R., Helena Schmidt (174915), Aspelund, T, Deshmukh, Harshal, Elizabeth G Holliday, Wheeler HE, Oostra, B.A., Pirastu Mario, Stumvoll M, Turner, S.T., Völker U., Glazer N., Mitchell, P., Atkinson E.J., Chu A.Y., Paul Mitchell, Peter Kovacs (103720), Martin Adam (175082), Wilson, JF, Yang Q, Rossella Sorice, Alan R. Shuldiner (110828), Böger, Casten A, Tiit Nikopensius, Ernst Florian, Portas, L., Sorice, R, Taliun Daniel, Nikopensius T., Jukema J.W., Li, G., Metzger M., Cavalieri, M. (Margherita), Cinzia Sala, Zaboli G, Glazer Nicole, Pistis Giorgio, Kao, W. H. Linda, Wilson, J.F. (James), Murgia, F, Foster, M.C., Pattaro C., Wright A.F., Kardia, S.L.R. (Sharon), Andre Franke, Ellinghaus D, Braxton D Mitchell, Yurii S. Aulchenko (148330), Mitchell B.D., Peter Kovacs, Kaehoenen, Mika, Stracke S., Li, G (Guo), Rivadeneira Ramirez, F. (Fernando), Mario Pirastu (175088), Olden M, Ford, I. (Ian), Oostra B.A., Campbell, H. (Harry), Holliday EG, Wichmann, H.-E., Ciullo M, Lenore J. Launer (110269), Hu, F.B., Kao, W.H.L., Buckley, BM, WTCCC2, Gao, X, Thomas Illig (44906), Sala, C, Colhoun, Helen, Van Duijn, CM, Demirkan, A., Bochud, Murielle, Yang Q., Aspelund T, Eiriksdottir, G, Gasparini, P., Nikopensius Tiit, Wang, JJ, Uitterlinden, AG, Illig, T. (Thomas), Homuth G., Tamara B Harris, Deshmukh Harshal, Vitart Veronique, Madhumathi Rao, Chen MH, Haun, Margot, Hundertmark C., Carsten A Böger, Giulianini, F., Chu, Audrey Y, Aspelund, T. (Thor), Andrews Jeanette S., Madhumathi Rao (174925), Margherita Cavalieri (174919), Kronenberg F., Nauck, M., Cosetta Minelli, Campbell, Harry; id_orcid, Metzger Marie, Ferrucci, L. (Luigi), Sharon L R Kardia, Kolcic, I., Wheeler, HE, Kollerits, Barbara, Angela Döring (64291), de Andrade Mariza, Florian Ernst (174614), David Ellinghaus (87596), Liu CT, Ford, Ian, Conall M. O'Seaghdha (174855), Ford I., Colhoun H., Daniela Toniolo, Imboden M., Zemunik T., Shuldiner, A.R., Ingrid Borecki (175089), Kutalik Zoltan, Boerwinkle E., Paulweber Bernhard, Liu Y, Pattaro C, Wild Sarah H., Kovacs Peter, Province, M., Sorice R., Prokopenko, Inga, Hwang S.-J., Bergmann, Sven, Launer, Lenore J., Fox, C. S., Bergmann, S.M. (Sven), Wichmann, H. E., Giulianini Franco, Garnaas, M., Jacobs G., Imboden, M. (Medea), Franke Andre, Parsa A, Magi, Reedik, Liu, C.-T., Esko, T, David S. Siscovick (174822), Gierman Hinco J., David Ellinghaus, Brendan M. Buckley (175076), Buckley Brendan M., Lohman, K, Nikopensius, T, Aulchenko, Y. S., Boban, M, Maija Garnaas, Gunnar Jacobs (174977), Andre G. Uitterlinden (89938), Minelli C., Jukema, J.W., Schmidt, Helena, Ferrucci L., Luigi Ferrucci, Koenig, W, Stumvoll M., Probst-Hensch, N.M., Gyllensten U., Homuth, G., Mika Kähönen, H-Erich Wichmann, Meredith C Foster, Uitterlinden, A. G., Jacobs, Gunar, Andres Metspalu (61760), Sorice, Rossella, Fuchsberger, Christian, Goessling, Wolfram, Curhan Gary C., Coresh J, Haun M, Paolo Gasparini (139832), Laura Portas, Esko Tõnu, Rainer Rettig (112747), Endlich K., Freedman, B.I., Haun, M. (Margot), Polasek, O., Chu AY, Hinco J Gierman, Ayse Demirkan (174933), Endlich, Karlhans, Homuth, Georg, Harris, TB, Nöthlings Ute, Hundertmark, C., Zemunik, T. (Tatijana), Sorice, R., Franke, A. (Andre), O'Connell, J.R., Kollerits B, Jingzhong Ding (165392), Province Michael, Elizabeth J. Atkinson (174866), Li, Guo, Oostra, B.A. (Ben), Gao X, Kao W.H.L., Ruggiero Daniela, Parsa Afshin, Yongmei Liu, Antonietta Robino (149863), Vitart, V, Mitchell, B.D. (Braxton), Fuchsberger C, Raitakari O., Hayward, C, Pramstaller PP, Deshmukh H., Rossella Sorice (140754), Vilmundur Gudnason (8873), Borecki, I.B. (Ingrid), Gyllensten, U. (Ulf), Gorski, M, Eiriksdottir Gudny, Böger, CA, Audrey Y. Chu (174895), W. H. Linda Kao (160779), Helena Schmidt, Probst Hensch NM, Ding J., Igor Rudan, Wichmann, H. -Erich, Siscovick, D.S. (David), Paulweber, Bernhard, O'Seaghdha, C. M., Ferrucci, L., Foster Meredith C., Oostra, B. A., Palmer C., O'Seaghdha, C.M., Marie Metzger, Henry Völzke, Antonietta Robino, Esko T, Alex Doney (175054), Isaacs, A, Tönjes, A, Gudnason V., Lehtimäki, T, Helen Colhoun, Cornelis, Marilyn, Giulianini F, Thun Gian-Andri, Campbell, H, Claudia Hundertmark (174852), Hofman, Bert, Wright, A. F., Kutalik Z., Toniolo, D., Hwang SJ, Eiriksdottir G, Kolcic, I, Ferrucci, Luigi, Teumer A., Johnson A.D., Bernhard K Krämer, Olden, M., Olden, M, Hundertmark Claudia, Michael Stumvoll, Mägi R., Jorma Viikari, Witteman JC, Ulivi, Sheila, Kim, Stuart K., Heid, IM, Fuchsberger, C, Wichmann, H.-Erich, Heyo K Kroemer, Uitterlinden, André, Anke Tönjes, Krämer, Bernhard K., Tin A, Hundertmark, Claudia, Siscovick, DS, Struchalin, Maksim, Gao, X.Y., Kollerits, B. (Barbara), Holliday, EG, Gian-Andri Thun (142891), Sven Bergmann, Albert V. Smith (103644), Johansson Åsa, Stella Trompet, Murgia, F., Chen, M. H., Franco Giulianini, Lehtimaeki, Terho, Coresh, J. (Josef), Nothlings, Ute, Olden, M. (Matthias), Michael Province (175044), Demirkan Ayse, Wild, S.H., de Andrade, M., James F Wilson, Eiriksdottir, G., Eric Boerwinkle (36288), Federico Murgia (174898), Bernhard Paulweber (102633), Robino Antonietta, Johnson, AD, Alan F Wright, Metspalu A, Mitchell Paul, Catherine Helmer (175026), Wheeler, Heather E., Medea Imboden (110145), Gorski, M., Probst-Hensch, N. M., Caroline Hayward, Krämer B.K., Harris, Tamara B., Chouraki, Vincent, Trompet S, Giulianini, Franco, Harry Campbell, Ivana Kolcic (3212697), Frank B. Hu (127167), Launer, LJ (Lenore), Demirkan, Ayse, Schmidt, R, Uitterlinden, André; id_orcid, Schmidt, H, Ben A Oostra, Province, Michael, Veronique Vitart, Rivadeneira, F., Helmer, C, Hayward Caroline, Reiner Biffar (135695), Viikari, J, Rudan, Igor, Anna Köttgen (3111024), Mitchell Braxton D., Völzke H, Koenig Wolfgang, Martin Adam, Veronique Vitart (149854), Sylvia Stracke (175001), Turner S.T., Guo Li, Wilson, J. F., Dehghan, A. (Abbas), Smith, A. V., Völzke, H., Freedman, Barry I., Dehghan A., Igl W., Harris Tamara B., Köttgen A., Rettig, R., Chouraki V, Province, M, Ellinghaus David, Tin, A, Palmer, Colin, Jacobs Gunnar, Holliday, E.G. (Elizabeth), Rainer Rettig, Uitterlinden, A.G., Teumer A, Sarah H Wild, Pramstaller P.P., Biffar, R. (Reiner), Ford I, Wheeler, H. E., Nauck, M. (Matthias), Ridker, P.M. (Paul), Polasek Ozren, Adam, M., Kutalik, Z., Ferrucci L, Margherita Cavalieri, Oostra BA, Cornelis, M. (Marilyn), Alan F. Wright (150085), Kolcic, Ivana, Olden Matthias, Goessling, W., Tönjes A, Chouraki Vincent, Raitakari, O. (Olli), Hofman, A, Cavalieri, Margherita, Doney A, Hwang, S.-J., Angela Döring, Rudan, I, Curhan, G.C., Metspalu A., Launer, LJ, Vitart, V., Andrew D Johnson, Thun, GA, Thor Aspelund (103668), Döring, A, Isaacs A, Witteman, J.C.M. (Jacqueline), Christian Fuchsberger, Chen, M-H. (Ming-Huei), O'Connell, Jeffrey R., Hayward, Caroline; id_orcid, Uwe Völker, Vollenweider, P. (Peter), Pattaro, C. (Cristian), Polasek, O, Launer L.J., Michael Stumvoll (103716), Gierman, H.J., Palmer C, Johnson Andrew D., Chouraki, V., Krämer, BK, Ding, J., Caroline Hayward (149856), Paulweber B., Zaboli, Ghazal, Hastie Nick, Rivadeneira F., Mitchell P., Pirastu, Mario, Wang, Jie Jin, Gorski Mathias, Lehtimäki Terho, Nöthlings, U, Igor Rudan (150101), Borecki Ingrid, Shamika Ketkar, Curhan G.C., Illig T., Nicole Glazer (113632), Rao, M, Uitterlinden, Andre G., Rettig, Rainer, Schmidt R., Reinhold Schmidt, Ketkar, Shamika, Heid IM, Stella Trompet (174901), Zoltan Kutalik, Wheeler Heather E., Kronenberg, F. (Florian), Kutalik, Zoltan, Johansson, Asa, Johansson Å, Gasparini, P, Kronenberg, Florian, Elizabeth J Atkinson, Hofman, A., Sarah H. Wild (130180), Smith, Albert V, Schmidt, Reinhold, Palmer, C.N.A. (Colin), Vollenweider P., Doney Alex, Wilson JF, Minelli Cosetta, Ulivi, S. (Shelia), Prokopenko I, Gorski, Mathias, Struchalin M, Ridker, P, Hu FB, Kollerits, B, Heather E Wheeler, Toniolo D., Hofman Albert, Sala, Cinzia, Lehtimäki, Terho, Andres Metspalu, Abbas Dehghan, Kurt Lohman, O'Seaghdha, CM, Mladen Boban (149857), Kähönen Mika, Krämer Bernhard K., Gyllensten, U., Pramstaller, P.P. (Peter Paul), Qiong Yang (28822), Kähönen, M, O'Seaghdha, Conall M., Kurt Lohman (110218), Biffar, R, Thomas Illig, Ghazal Zaboli, Cornelis, Marilyn C., Launer, L.J., Homuth G, Chasman, Daniel I., Sala C, Mägi Reedik, Fernando Rivadeneira, Launer LJ, Zaboli G., de Andrade, Mariza, Shih-Jen Hwang, Jeanette S. Andrews (174941), Marina Ciullo (140763), Ulivi Sheila, Tamara B. Harris (110195), Atkinson Elizabeth J., Holliday, Elizabeth G., Daniel I Chasman, Yang, Qiong, Braxton D. Mitchell (110791), Kollerits Barbara, Gierman, Hinco J, Kovacs, P., Gierman HJ, Atkinson, E. J., Kardia Sharon L. R., Ciullo M., Isaacs, Aaron; id_orcid, Andrews J.S., Duijn, C.M. van, Lohman Kurt, Shih-Jen Hwang (79945), Harris TB, Zemunik Tatijana, Franke, A, Bergmann S, Paul Ridker, Ruggiero, D, Gierman, HJ, Gyllensten, Ulf, Helmer C, Nikopensius T, Franke A, Bochud M, Fuchsberger C., Dehghan, Abbas, Atkinson, EJ, Cristian Pattaro, Minelli C, Caroline S Fox, Schmidt Helena, Pramstaller, P. P., Taliun D., O'Connell, J. R., Demirkan A., van Duijn C.M., James F. Wilson (150146), Böger, C. A., Bergmann S., Palmer Colin, Johnson AD, Wright, A.F. (Alan), Stephen T. Turner (103474), Ching-Ti Liu (100170), Mary Feitosa (165417), Vitart, V. (Veronique), Pistis G., Ridker Paul, Margot Haun, H.-Erich Wichmann (72009), Ian Ford (30666), Harry Campbell (30339), Boban Mladen, Freedman BI, Pirastu M., Ulivi, S., Raitakari, Olli, Krämer BK, Rudan Igor, Rudan, I., Jukema, J. W., Ulivi S., Franco Giulianini (175060), Wilson, James F., Sala, C. (Cinzia), Chu, Audrey Y., Hinco J. Gierman (174862), Ulf Gyllensten (13773), Siscovick, D. S., Stracke, S., Doney, A, Metzger M, Li, Man, Wang, J. J., Illig, Thomas, Tõnu Esko (102379), Döring, A. (Angela), Hu, Frank, Völker Uwe, Mary Feitosa, Igl, W, Chen, M.-H., Koenig W, Adam, M, Vitart V, O'Connell, Jeffrey R, Ketkar S., Imboden Medea, Cosetta Minelli (38846), Johnson, Andrew D., Reiner Biffar, Völzke H., Matthias Olden, Mariza de Andrade, Aulchenko, Y.S. (Yurii), Hwang, Shih-Jen, Jukema JW, Portas L., Hwang, SJ, Polasek, O. (Ozren), Lohman, Kurt, Ford Ian, Wellcome Trust Case Control Consortium 2, Gyllensten, U, Vitart V., Harshal Deshmukh (174893), Freedman B.I., Caroline S. Fox (110474), Yang, Q. (Qiong Fang), Alexander Teumer (112757), Holliday, Elizabeth G, Kao W. H. Linda, Marilyn C. Cornelis (174871), Boger, C.A., Kroemer, H.K. (Heyo), Parsa, Afshin, Kovacs P., Tõnu Esko, Liu Ching-Ti, Dehghan Abbas, Buckley B.M., Jukema, J. Wouter, Haun, M, Anke Tönjes (103703), Johnson, A.D., Afshin Parsa, Ernst F., Vollenweider, P., Völker U, Jeffrey R. O'Connell (170220) +999 morecore +2 more sourcesPRMT5‐Dependent Stabilization of VPS34 Orchestrates Copper Trafficking to Shield Cancer Cells from Cuproptosis and Radiotherapy
Advanced Science, EarlyView.Radioresistance arises partly from tumor cells evading cuproptosis via unknown defenses. This study reveals that the PRMT5‐VPS34 axis acts as a radiation‐activated anticuproptotic mechanism: PRMT5 methylates VPS34 at Arg174, recruiting USP10 to remove K48‐linked ubiquitination and prevent degradation.Wei Chen, Ming‐Ying Xiao, Lan‐Lan Guo, Hao‐Yue Hu, Sui‐Xian Zhang, Bai‐Qiang Dong, Chen‐Fei Wu, Xia‐Hang Huang, Li Li, Run‐Zhe Chen, Yuan‐Yang Huang, Ying Jin, Hai Song, Ying Wang, Qi‐Wen Li, Ming Chen, Xuan Li, Yuan‐Yuan Chen +17 morewiley +1 more sourceEffect of Calcium Deficiency on Growth and Leaf Acid Soluble Proteins of Tomato [PDF]
, 2007 The effects of temporary Ca (Ca) calcium deficiency lasting 2, 3, 4 or 5 d were investigated on tomato plants at the 6-leaf stage, grown hydroponically under controlled conditions.Silvestre, Jérôme, Pinelli, Eric, Baboulène, Laurence, Morard, Philippe +3 morecore +1 more sourceBiomimetic Nanoplatform for Dual Target Nano‐Metabolic Therapy in Diabetes‐Associated Biofilm Infections
Advanced Science, EarlyView.A biomimetic GOx/Arg‐loaded nanoplatform produces nitric oxide through an in situ catalytic cascade reaction, enabling dual‐target metabolic regulation in diabetes‐associated biofilm infections. Bacterial metabolism is disrupted, and macrophage immunometabolism is reprogrammed, resulting in biofilm eradication, immune restoration, and enhanced ...Mingzhang Li, Yonglong Li, Jiren Yan, Changming Wang, Jinlong Yu, Feng Jiang, Boyong Wang, Yi Yang, Deyi Ding, Jin Tang, Pei Han, Botao Song, Geyong Guo, Hao Shen +13 morewiley +1 more sourceUrokinase-Type Plasminogen Activator Promotes Paracellular Transmigration of Neutrophils Via Mac-1, But Independently of Urokinase-Type Plasminogen Activator Receptor [PDF]
, 2011 Background: Urokinase-type plasminogen activator (uPA) has recently been implicated in the pathogenesis of ischemia-reperfusion (I/R) injury. The underlying mechanisms remain largely unclear.Paul J. Declerck, Rehberg, Markus, Daniel Puhr-Westerheide, Lerchenberger, Max, Uhl, Bernd, Kanse, Sandip, Johanna Liebl, Reichel, Christoph A., Bernd Uhl, Markus Rehberg, Zahler, Stefan, Lorenzl, Stefan, Elisabeth Deindl, Khandoga, Andrej, Declerck, Paul J., Stefan Zahler, Schmalix, Wolfgang, Fritz Krombach, Liebl, Johanna, Christoph A. Reichel, Krombach, Fritz, Max Lerchenberger, Andrej Khandoga, Stefan Lorenzl, Deindl, Elisabeth, Wolfgang Schmalix, Puhr-Westerheide, Daniel, Sandip Kanse +27 morecore +1 more sourcePFKFB4 Deubiquitination by USP10 Enhances Fumarate Metabolism to Orchestrate the KDM1A/Rad51 Axis and Confer Radioresistance in Lung Cancer
Advanced Science, EarlyView.USP10 binds to and stabilizes PFKFB4, enhancing glycolytic ATP production, which activates the urea cycle and elevates fumarate. This inhibits histone demethylase KDM1A, leading to increased H3K4me1 enrichment at the Rad51 promoter and direct activation of Rad51 transcription, which confers lung cancer radioresistance. The PFKFB4 inhibitor 5MPN targets Yunshang Chen, Zilong Wu, Yongqiang Yang, Ruoxin Fang, Huichan Xue, Rui Zhou, Gang Wu, Xiaohua Jie +7 morewiley +1 more sourceMicroalgae Hybrid Biosystem for Enhanced Oral Delivery of Rifaximin in Hepatic Encephalopathy Treatment
Advanced Science, EarlyView.The microalgae‐nanoparticle hybrid system with antibacterial activity can improve the oral delivery and therapeutic efficiency for hepatic encephalopathy treatment. Oral administration of the system can reduced systemic ammonia levels, enhanced intestinal barrier function, attenuated systemic and neuroinflammation, ameliorated cognitive impairments ...Kaiyue Wang, Xueting Huang, Lingxiao Yang, Jin Liu, Lei Lei, Shaomin Zou, Kai Wang, Min Zhou, Zhe Tang +8 morewiley +1 more source
