Results 81 to 90 of about 13,595,196 (243)

Harmonizing Rigidity and Flexibility: Embedding COF Quantum Dots Into Extracellular Matrix Gel as Carbon Monoxide Depot for Acoustically Triggered Time‐Programmable Anti‐Infective Therapy

Advanced Science, EarlyView.
A rigid‑flexible integrated CO depot is engineered by embedding rigid COFQDs into a flexible ECM gel network. The rigid framework enables high‑capacity CO storage and sonodynamic bacterial killing, while the flexible ECM gel controls sustained CO release, collectively eradicating multidrug‑resistant infection and promoting scarless healing.
Baohong Sun, Fang Han, Chunxiao Zhu, Zhiyuan Yang, Haoru Wang, Jinpei Mei, Jie Chen, Jingwen Zhu, Zihan Bo, Taju Wu, Xiaogang Zhou, Tao Ma, Yutian Su, Youhui Lin   +13 more
wiley   +1 more source

The Physiological, Biochemical, and Pathological Characteristics of Adenine-Induced Kidney-Yang Deficiency in Rats

Introduction: Kidney-Yang deficiency is a syndrome crucial for understanding the function of traditional Chinese medicine (TCM) in kidney diseases.
Rong-Rui Wei, Qing-Gang Zhou, Wen-Min Liu, Guo-Yue Zhong, Xu-Tao Wu, Qing-Yuan Lin, Qin-Ge Ma, Zhao Geng   +7 more
core   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

The IRE1‐XBP1s Axis Drives Inflammatory Osteolysis by Regulating a 5‐HT Dependent Endogenous Anti‐Autophagy Mechanism

Advanced Science, EarlyView.
A previously unrecognized IRE1‐XBP1s‐Slc6a4 signaling axis links endoplasmic reticulum stress to serotonin metabolism, autophagy, and inflammatory osteoclastogenesis. By promoting intracellular serotonin uptake and reducing endogenous 3‐methyladenine accumulation, this pathway accelerates inflammatory bone destruction and provides a promising ...
Pengchao Yang, Binxiang Zhu, Yuzhi He, Yang Tian, Honglei Kang, Shian Hu, Pengju Wang, Yong Xu, Zhuowei Lei, Peijun Qi, Hao Yang, Yang Lin, Yimin Dong, Feng Li, Hanfeng Guan   +14 more
wiley   +1 more source

Glucose-induced down regulation of thiamine transporters in the kidney proximal tubular epithelium produces thiamine insufficiency in diabetes [PDF]

, 2012
Increased renal clearance of thiamine (vitamin B1) occurs in experimental and clinical diabetes producing thiamine insufficiency mediated by impaired tubular re-uptake and linked to the development of diabetic nephropathy.
Larkin James R., Guerman Molostvov, Fang Zhang, Naila Rabbani, Thornalley, Paul J., Zhang Fang, Zhang, F. (Fang), Rabbani, Naila, Godfrey Lisa, Molostvov Guerman, James R Larkin, Zehnder Daniel, Paul J. Thornalley, Lisa Godfrey, Zehnder, Daniel, Daniel Zehnder, Godfrey, L. (Lisa), Rabbani Naila, Larkin, James Robert, Thornalley Paul J., Paul J Thornalley, James R. Larkin, Molostvov, Guerman   +22 more
core   +2 more sources

ANGPTL4 Exacerbates Renal Injury in Diabetic Kidney Disease by Impairing Podocyte Lipophagy via Compromised Lysosomal Degradative Function

Advanced Science, EarlyView.
In diabetic kidney disease, elevated podocyte ANGPTL4 is linked to reduced TFEB nuclear localization and compromised lysosomal degradative function. These changes impair podocyte lipophagy and promote lipid‐droplet accumulation and podocyte injury, which may contribute to renal injury progression.
Xiaojing Liu, Shimin Jiang, Zhenkun Yang, Shunlai Shang, Jiayi Li, Guming Zou, Cheng Zhou, Wenge Li   +7 more
wiley   +1 more source

Chemokine receptor CCR1: A new target for progressive kidney disease [PDF]

, 2005
Infiltrating leukocytes are thought to contribute to the progression of kidney disease. Locally produced chemokines guide circulating leukocytes into the kidney, which renders therapeutic blockade of respective chemokine receptors on the leukocyte ...
Hans-Joachim Anders, Ninichuk, Volha, Anders, Hans-Joachim, Volha Ninichuk   +3 more
core   +1 more source

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

Clinical observation on treatment of patients with kidney-yang deficiency type ankylosing spondylitis by using Bushen Tongdu external treatment

针刺研究
ObjectiveTo observe and evaluate the effectiveness and safety of Bushen Tongdu （reinforcing the kidney-yang and regulating the Governor Vessel） external treatment for patients with kidney-yang deficiency type ankylosing spondylitis （AS）.MethodsPatients ...
ZHOU Xing-yu, WANG Xin-yi, ZHANG Yu-fei, WANG Xiao-long, ZHANG Xiu-xiu, LIU Yuan-yuan, LI Peng-yan, TIAN Yuan-sheng   +7 more
doaj   +2 more sources

A Study on the Biological Characteristics of Kidney Yin Deficiency and Kidney Yang Deficiency Models in SPF-grade Kunming Mice

Objective: To investigate the establishment and biological characteristics of Kidney Yin Deficiency (KYD) and Kidney Yang Deficiency (KYD) models in Specific Pathogen Free (SPF)-grade Kunming mice.
Jie Wang, Lihe Jiang, Yuanyuan Yang, Shuangshuang Li, Zaohua Deng, Jin Li, Xueping Feng   +6 more
core   +1 more source