Results 131 to 140 of about 29,224 (355)
Advanced Functional Materials, EarlyView.Porous silicon nanoparticles (PSiNPs) reprogram macrophage endocytosis of manganese@albumin‐based TLR4 nanoagonists, driving TRIF‐biased TLR4 signaling, eliciting robust proinflammatory responses, and potentiating macrophage‐mediated immunotherapeutic effects against NSCLC.
Xiaomei Zhang +9 more
wiley +1 more source
Advanced Functional Materials, EarlyView.This study demonstrates that the dual delivery of BMP‐2/‐7 coding cmRNAs for bone healing is demonstrated as feasible, safe, and highly osteogenic. Compared to single BMP‐2 or BMP‐7 cmRNAs, the combination enhances the production of both mineral and organic components of the extracellular matrix when delivered using a collagen‐HA scaffold, supporting ...
Claudia Del Toro Runzer +7 more
wiley +1 more source
Modeling Provider Knowledge, Skills, and Abilities (KSA) [PDF]
No abstract ...
Levin, Dana, Mcguire, Kerry M.
core +1 more source
Smart Nanogels as Enzyme‐Driven Nanomotors for Navigating Viscous Physiological Barriers
Advanced Functional Materials, EarlyView.Two families of urease‐powered nanomotors (NMs), with and without a p‐(2‐hydroxyethyl methacrylate) (p‐HEMA) shell, have been successfully prepared. Both types exhibit effective motion in highly viscous synovial fluid media at low urea concentrations (25 mM).
David Esporrín‐Ubieto +6 more
wiley +1 more source
Self‐Immolative Activatable Nanoassembly toward Immuno‐Photodynamic Therapy in TME
Advanced Functional Materials, EarlyView.A quinone methide‐gated, self‐immolative, H2O2‐responsive nano‐photosensitizer (Pyz/PS) is developed for targeted immuno‐photodynamic therapy. Pyz/PS selectively activates within tumor microenvironments, restores photosensitizer activity, generates ROS, and depletes intracellular GSH, enhancing oxidative stress.
Jing Li +10 more
wiley +1 more source
Implementation of Drug‐Induced Rhabdomyolysis and Acute Kidney Injury in Microphysiological System
Advanced Functional Materials, EarlyView.A modular Muscle–Kidney proximal tubule‐on‐a‐chip integrates 3D skeletal muscle and renal proximal tubule tissues to model drug‐induced rhabdomyolysis and acute kidney injury. The coculture system enables dynamic tissue interaction, functional contraction monitoring, and quantification of nephrotoxicity, revealing drug side effect‐induced metabolic ...
Jaesang Kim +4 more
wiley +1 more source
Free‐Form Microfluidic Microneedle Array Patches
Advanced Functional Materials, EarlyView.Microfluidic microneedle array patches (MAPs) integrate hollow microneedles with embedded microfluidic channels, fabricated using high‐resolution 3D printing, to enable controlled transdermal delivery of liquid, mixed, or reconstituted therapeutics.
Ian A. Coates +11 more
wiley +1 more source
酸性尿酸アンモニウム結石を伴ったEncrusted cystitisの1例 [PDF]
, 2002 88歳男, 間質性肺炎に対し他院で治療中血膿尿を認め紹介転院した.KUB・CT・膀胱鏡にて膀胱内面ほぼ3分の2に石灰化を認め病理所見にてbacterial colonyとそれに伴う炎症細胞の浸潤・石灰化を認めた.またその際の結石分析で酸性尿酸アンモニウム結石と診断されたWe present a case of encrusted cystitis with ammonium acid urate calculi.
Ito, Masaaki +3 more
core
Advanced Functional Materials, EarlyView.This research presents a novel implantable bio‐battery, GF‐OsG, tailored for diabetic bone repair. GF‐OsG generates microcurrents in high‐glucose conditions to enhance vascularization, shift macrophages to the M2 phenotype, and regulate immune responses.
Nanning Lv +10 more
wiley +1 more source
Advanced Functional Materials, EarlyView.A bimetallic Mn–Ca nanoreactor (MCC) is developed as a non‐nucleotide STING nanoagonist for cancer metalloimmunotherapy. MCC induces Ca2+ overload and hydroxyl radical generation, resulting in mitochondrial damage and mtDNA release. The released mtDNA cooperates with Mn2+ to robustly activate cGAS–STING signaling.
Xin Wang Mo +7 more
wiley +1 more source