Results 161 to 170 of about 9,202 (217)

Neuronal C/EBPβ Shortens the Lifespan via Inactivating NAMPT

Advanced Science, EarlyView.
Schematic diagram illustrating the mechanism of shortened lifespan in Thy 1‐C/EBPβ transgenic mice and intervention strategies. Briefly, C/EBPβ/AEP escalation in the aging brain triggers NAMPT fragmentation and NAD+ depletion. Knockout of AEP from Thy 1‐C/EBPβ Tg/Tg mice ameliorates cognitive impairments and elongates the lifespan.
Bowei Li, Zhongyun Xie, Mengmeng Wang, Shuke Nie, Zhengjiang Qian, Xin Meng, Xia Liu, Seong Su Kang, Keqiang Ye   +8 more
wiley   +1 more source

Tumor Microenvironment Triggered In Situ Coagulation of Supramolecularly Engineered Platelets for Precise Tumor Embolization

Advanced Science, EarlyView.
Occlusion of tumor blood vessels represents a promising yet challenging approach in cancer treatment. Herein, supramolecularly engineered platelets conjugated with morphology‐transformable nanoparticles is developed for precise tumor embolization. The engineered platelets actively accumulate at tumor sites following induced blood vessel injury.
Junyan Li, Ziyi Wang, Ruifeng Luo, Xingping Quan, Hong U Fong, Qian Cheng, Jianwen Wei, Leo Wang, Yonghua Zhao, Ruibing Wang   +9 more
wiley   +1 more source

PSMD14 Stabilizes SLC7A11 to Ameliorate Glucocorticoid‐Induced Osteoporosis by Suppressing Osteocyte Ferroptosis

Advanced Science, EarlyView.
Glucocorticoid‐induced osteoporosis (GIOP) triggers osteocyte ferroptosis via SLC7A11 degradation. PSMD14 stabilizes SLC7A11 by counteracting glucocorticoid‐driven ubiquitination, preserving cystine uptake and glutathione synthesis. AAV‐mediated PSMD14 delivery or its agonist Pantethine rescues osteocyte survival and bone loss in GIOP mice.
Yifeng Shi, Qian Tang, Sunren Sheng, Hongyi Jiang, Chen Jin, Chencheng Zhou, Chenglong Xie, Lin Zheng, Di Zhang, Hui Xu, Cong Xu, Haiwei Ma, Guangheng Xiang, Wenfei Ni, Xiaoyun Pan, Lei Yang, Huazi Xu, Yu Qian, Aimin Wu, Xiangyang Wang, Gang Zheng   +20 more
wiley   +1 more source

Diallyl Trisulfide From Garlic Regulates RAB18 Phase Separation to Inhibit Lipophagy and Induce Cuproptosis in Hepatic Stellate Cells for Antifibrotic Effects

Advanced Science, EarlyView.
Diallyl trisulfides (DATs) selectively induce cuproptosis in hepatic stellate cells (HSCs) by targeting Ras‐related protein Rab‐18 (RAB18) and regulating lipophagy. DATs promote RAB18 phase separation, enhance mitochondrial‐associated membrane structures (MAMs) formation, and increase succinylation of dihydrolipoamide dehydrogenase (DLD) at K320.
Haoyuan Tian, Shujiang Sun, Xinran Qiu, Junrui Wang, Yuanyuan Gao, Jianmei Chen, Xiang Han, Zhengyang Bao, Xiaohan Guo, Yuqi Sun, Yuxin Lin, Mengru Hu, Feng Zhang, Zili Zhang, Feixia Wang, Shizhong Zheng, Jiangjuan Shao   +16 more
wiley   +1 more source

Penile Detumescence [PDF]

, 1991
Aboseif, Sherif R., Bosch, Ruud J. L. H., Bénard, Francois, Lue, Tom F., Stief, Christian Georg, Tanagho, Emil A.   +5 more
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Management of Calculi in A Donor Kidney

Transplantation Proceedings, 2007
We evaluated the safety and efficacy of ex vivo ureteroscopy (ExURS) and extracorporeal shock wave lithotripsy (ESWL) as means of rendering a donated kidney stone-free in living related and deceased donor renal transplantation.Three cases with calculi in donor kidneys were managed; 1 was from a living related donor and 2 were from deceased donors ...
Pranjal R Modi, Amal N. Trivedi, Rajiv Goel, Jamal Rizvi, Suhag Patel, Amit Devra   +5 more
openaire   +3 more sources

Staghorn Calculi of the Kidneys

European Urology, 1976
A series of 91 staghorn calculi are reviewed. Possible aetiological factors are analysed. A high incidence of hypercalciuria was found, and the significance of this is discussed. The rates of complete stone clearance after conservative surgery are considered for different types of staghorn calculus and it is felt that local circulatory arrest with ...
W K Moores, P J O'Boyle
openaire   +2 more sources

kidney and ureter calculi

2019
Urinary stones are an ailment that can leave the patients asymptomatic or lead to significant morbidity or even mortality. Understanding the basic concepts of stone formation is vital in its prevention, which is key not only as a preventative measure but also to ensure patients do not form further stones. In this chapter, we discuss the pathophysiology
Aboumarzouk, Omar, Cook, Paul, Traxer, Olivier, Osther, Palle Jørn Sloth, Villa, Luca, Cloutier, Jonathan, Jung, Helene, Andreassen, Kim Hovgaard, Somani, Bhaskar   +8 more
openaire   +3 more sources

Staghorn Calculi of the Kidney: Classification and Therapy

British Journal of Urology, 1990
Summary— Following the introduction of new techniques, the reclassification of staghorn calculi is indicated in order to establish the most suitable form of treatment.Of 269 patients with staghorn calculi treated over a 3‐year period, 56% underwent extracorporeal Shockwave lithotripsy (ESWL) monotherapy; 16% required open surgery and the remaining 28 ...
DI SILVERIO, Franco, M. Gallucci, ALPI, Giorgio   +2 more
openaire   +4 more sources

Medullary Sponge Kidney and Staghorn Calculi

Urologia Internationalis, 1990
We describe a 65-year-old female with bilateral staghorn calculi who presented with a Proteus mirabilis perinephric abscess secondary to a ruptured lower pole hydrocalyx. Radiologic evidence was consistent with underlying medullary sponge kidney (MSK) disease. Despite expectations to the contrary, MSK, a disease notable for many risk factors capable of
Domenic A. Sica, Julia R. Nunley, Vernon Smith   +2 more
openaire   +3 more sources