Results 111 to 120 of about 921,567 (386)

Metabolic Consequences of Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Patients with rheumatoid arthritis (RA) may have metabolic disruption, which can contribute to adverse long‐term outcomes, for multiple reasons. Patients with RA appear to have a higher risk of sarcopenia, type 1 and type 2 diabetes mellitus, metabolic syndrome, and hypertension. Systemic inflammation in RA can cause a “lipid paradox,” with reduced low‐
Stevie Barry, Emily Sheng, Joshua F. Baker   +2 more
wiley   +1 more source

Renal parenchymal volume analysis: Clinical and research applications

BJUI Compass
Background and Objectives In most patients, the renal parenchymal volumes in each kidney directly correlate with function and can be used as a proxy to determine split renal function (SRF).
Carlos Munoz‐Lopez, Kieran Lewis, Nityam Rathi, Eran Maina, Akira Kazama, Anne Wong, Angelica Bartholomew, Worapat Attawettayanon, Yunlin Ye, Zhiling Zhang, Wen Dong, Rebecca A. Campbell, Nicholas Heller, Erick Remer, Christopher Weight, Steven C. Campbell   +15 more
doaj   +1 more source

Deprivation and Disease in Early Twentieth-Century America [PDF]

This paper explores how early life exposure to poverty and want adversely affects later life health outcomes. In particular, it examines how exposure to crowded housing conditions and impure drinking water undermines long-term health prospects and ...
Karen Clay, Werner Troesken
core  

Expression and regulatory effects on cancer cell behavior of NELL1 and NELL2 in human renal cell carcinoma [PDF]

, 2015
We thank Professors Michael Rehli, Yoshiaki Ito, and Kristian Helin for gifting plasmids, Dr. Alasdair MacKenzie (University of Aberdeen) for helpful discussion, and Mr. Takashi Mizukami, Ms. Ryoko Tokuda, and Ms.
Mizokami, Atsushi, Nakamoto, Masaru, Nakamura, Ritsuko, Namiki, Mikio, Ooi, Akishi, Oyama, Takeru, Tajiri, Ryosuke   +6 more
core   +1 more source

Lesion-Aware Cross-Phase Attention Network for Renal Tumor Subtype Classification on Multi-Phase CT Scans [PDF]

Computers in Biology and Medicine, 108746, 2024
Multi-phase computed tomography (CT) has been widely used for the preoperative diagnosis of kidney cancer due to its non-invasive nature and ability to characterize renal lesions. However, since enhancement patterns of renal lesions across CT phases are different even for the same lesion type, the visual assessment by radiologists suffers from inter ...
arxiv   +1 more source

Understanding Contributors of Resilience in Youth With Childhood‐Onset Systemic Lupus Erythematosus Through a Socioecological Lens: A Mixed‐Methods Study

Arthritis Care &Research, EarlyView.
Objective This study aimed to identify themes contributing to resilience in childhood‐onset systemic lupus erythematosus (cSLE), distinguish between profiles of resilience, and examine how they relate to underlying themes and patient characteristics. Methods We conducted a mixed‐methods study of 21 patients with cSLE aged 11 to 19 years at a Canadian ...
Isabella Zaffino, Louise Boulard, Joanna Law, Asha Jeyanathan, Lawrence Ng, Sandra Williams‐Reid, Kiah Reid, Angela Cortes, Eugene Cortes, Ashley Danguecan, Deborah M. Levy, Linda T. Hiraki, Andrea M. Knight   +12 more
wiley   +1 more source

Sphingosine 1-phosphate in renal diseases [PDF]

, 2013
Because of its highly bioactive properties sphingosine 1-phosphate (S1P) is an attractive target for the treatment of several diseases. Since the expression of sphingosine kinases as well as S1P receptors was demonstrated in the kidney, questions about ...
Huwiler, Andrea, Koch, Alexander, Pfeilschifter, Josef Martin   +2 more
core   +2 more sources

Activation of SIRT1 Reduces Renal Tubular Epithelial Cells Fibrosis in Hypoxia Through SIRT1‐FoxO1‐FoxO3‐Autophagy Pathway

Advanced Biology, EarlyView.
Hypoxia promotes the epithelial‐mesenchymal transition (EMT) of renal tubular epithelial cells via the SIRT1‐FoxO1‐FoxO3‐autophagy pathway, thereby resulting in the fibrosis of renal tubular epithelial cells. Activation of SIRT1 or induction of autophagy inhibits this process, alleviating hypoxia‐induced fibrosis.
Guangyu Wang, Lijuan Zhang, Jiaorong Tan, Fei Li, Yishan Jin, Limei He, Xin Yang   +6 more
wiley   +1 more source

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

Involvement of heparanase in the pathogenesis of acute kidney injury: Nephroprotective effect of PG545 [PDF]

, 2017
Despite the high prevalence of acute kidney injury (AKI) and its association with increased morbidity and mortality, therapeutic approaches for AKI are disappointing. This is largely attributed to poor understanding of the pathogenesis of AKI. Heparanase,
Abassi, Zaid, Bellin, Gloria, Gambaro, Giovani, Hammond, Edward, Hamoud, Shadi, Hassan, Ahmad, Heyman, Samuel N., Ilan, Neta, Khamaysi, Iyad, Lupo, Antonio, Masola, Valentina, Muhammad, Rabia Shekh, Nativ, Omri, Onisto, Maurizio, Singh, Preeti, Vlodavsky, Israel, Zaza, Gianluigi   +16 more
core   +1 more source