Results 151 to 160 of about 1,036,066 (335)

Gastrin-Releasing Peptide Receptors Stimulate MAPK-Mediated Growth of Lung Cancer Cells by Transactivating HER4 in a Neuregulin-1, MAP Kinase-Dependent Manner Requiring Activation of the ROS-System

Biology
The bombesin (Bn) receptor family [Gastrin-releasing peptide (GRPR/BB2R) and Neuromedin B receptors (NMBR/BB1R)] are G-protein coupled receptors (GPCR’s) with potent growth effects on normal tissues/numerous cancers, often by transactivating the ErbB ...
Terry W. Moody, Irene Ramos-Alvarez, Tatiana Iordanskaia, Samuel A. Mantey, Robert T. Jensen   +4 more
doaj   +1 more source

Oral Dosed Organo‐Silica Nanoparticles Restore Glucose Homeostasis and β‐Cell Function in Diabetes Rats

Advanced Functional Materials, EarlyView.
An oral nanoplatform, MOP@T@D, which can maintain glucose homeostasis and restore islet β cells in diabetic rats is developed. It achieves efficient intestinal absorption and liver‐targeted delivery. The nanoparticle disintegrates only in response to hyperglycemia to release insulin on demand and provides antioxidant protection through selenoprotein ...
Chenxiao Chu, Mingli Wei, Che Bian, Xiaoshuang Bi, Yaxin Deng, Peifu Xiao, Jiansong Zhao, Yuying Wang, Haibing He, Jingxin Gou, Tian Yin, Xing Tang, Li Yang, Hongbo Zhang, Yu Zhang   +14 more
wiley   +1 more source

Single-cell transcriptomes underscore genetically distinct tumor characteristics and microenvironment for hereditary kidney cancers [PDF]

, 2022
Ryosuke Jikuya, K. Murakami, Akira Nishiyama, Ikuma Kato, Mitsuko Furuya, Jun Nakabayashi, Jordan A. Ramilowski, Haruka Hamanoue, Kazuhiro Maejima, Masashi Fujita, Taku Mitome, Shinji Ohtake, Go Noguchi, Sachi Kawaura, Hisakazu Odaka, Takashi Kawahara, Mitsuru Komeya, Risa Shinoki, Daiki Ueno, Hiroki Ito, Yusuke Ito, Kentaro Muraoka, Narihiko Hayashi, Keiichi Kondo, Noboru Nakaigawa, Koji Hatano, Masaya Baba, Toshio Suda, Tatsuhiko Kodama, Satoshi Fujii, Kazuhide Makiyama, Masahiro Yao, Brian Shuch, Laura S. Schmidt, W. Marston Linehan, Hidewaki Nakagawa, Tomohiko Tamura, Hisashi Hasumi   +37 more
openalex   +1 more source

Synthetic Nanobiology Actuated Lipometabolic Cell Factory for Autologous Tumor Immunotherapy

Advanced Functional Materials, EarlyView.
FA plays a crucial role in the interaction between tumor cells and the tumor microenvironment, especially for the immune response. A biocatalytic immunoenhancement strategy is developed to boost antitumor immunity by FA metabolic orientation to ceramide. Through the design of this delicate catalytic immunoenhancement strategy, the synthetic nanobiology
Shoujie Zhao, Yejing Zhu, Hengchao Yu, Jun Zhu, Bo Wang, Yu Qiao, Zhimin Tian, Junlong Zhao, Lei Liu   +8 more
wiley   +1 more source

Dynamic mechanism of GPCR-mediated β-arrestin: a potential therapeutic agent discovery of biased drug

Signal Transduction and Targeted Therapy, 2022
Zheng Xu, Zhenhua Shao
doaj   +1 more source

The patatin-like protein PlpD forms structurally dynamic homodimers in the Pseudomonas aeruginosa outer membrane

Nature Communications
Members of the Omp85 superfamily of outer membrane proteins (OMPs) found in Gram-negative bacteria, mitochondria and chloroplasts are characterized by a distinctive 16-stranded β-barrel transmembrane domain and at least one periplasmic POTRA domain.
Sarah E. Hanson, Tyrone Dowdy, Mioara Larion, Matthew Thomas Doyle, Harris D. Bernstein   +4 more
doaj   +1 more source

Genetic Analysis and Targeted Therapy Using Buparlisib and MK2206 in a Patient with Triple Metachronous Cancers of the Kidney, Prostate, and Squamous Cell Carcinoma of the Lung: A Case Report

, 2021
Tong Zhao, Yuqin Tian, Xinjia Ding, Lin Liu, Bowen Tan, Bin Yang, Jianlin Wu, Ting Lei, Ruoyu Wang, Yan Ding   +9 more
openalex   +2 more sources

RNA‐Micelles as Self‐Assembling Structures for Efficient Co‐Delivery of Synergistic siRNA and Nucleoside Analogues to Treat CRC Lung Metastasis

Advanced Functional Materials, EarlyView.
Two kinds of self‐assembled RNA micelles were used to co‐deliver synergistic siRNA and nucleoside analogues for the treatment of colorectal cancer lung metastases. Near‐complete elimination of lung cancer metastases was confirmed in an orthotopic lung metastasis model constructed using human colorectal cancer lung metastases patient surgical samples to
Kai Jin, Piotr Rychahou, Daniel W. Binzel, B. Mark Evers, Peixuan Guo   +4 more
wiley   +1 more source

METTL3 Potentiates M2 Macrophage‐Driven MMT to Aggravate Renal Allograft Fibrosis via the TGF‐β1/Smad3 Pathway

Advanced Science
METTL3, a key enzyme in N6‐methyladenosine (m6A) modification, plays a crucial role in the progression of renal fibrosis, particularly in chronic active renal allograft rejection (CAR).
Qinfan Yao, Xiaoxiao Zheng, Xinyi Zhang, Yucheng Wang, Qin Zhou, Junhao Lv, Li Zheng, Jiahua Lan, Wei Chen, Jianghua Chen, Dajin Chen   +10 more
doaj   +1 more source

Associations of ambient coarse particulate matter, nitrogen dioxide, and carbon monoxide with the risk of kidney disease: A cohort study [PDF]

, 2017
Al-Aly, Ziyad, Bowe, Benjamin, Li, Tingting, Xian, Hong, Xie, Yan, Yan, Yan   +5 more
core   +2 more sources