Results 181 to 190 of about 1,036,066 (335)

Photoactivated Proximity Protein Labeling Reveals Enhanced Tumor Retention of a D‐Peptide‐Ruthenium Prodrug Conjugate

Advanced Healthcare Materials, EarlyView.
Six stereoisomeric ruthenium‐peptide conjugates were synthesized and characterized, which showed high potential in photoactivated chemotherapy (PACT) and proximity protein labeling. Abstract Amino acid chirality is known to influence the biological properties of peptide‐containing prodrugs.
Liyan Zhang, Peiyuan Wang, Hildert Bronkhorst, Yurii Husiev, Ludovic Bretin, Maarten N. van Ginkel, Wen Sun, Sylvestre Bonnet   +7 more
wiley   +1 more source

Corrigendum to ‘‘Ontological analyses reveal clinically-significant clear cell renal cell carcinoma subtypes with convergent evolutionary trajectories into an aggressive type’’ [EBioMedicine 51 (2020) 102526]

EBioMedicine, 2020
Qi Cai, Alana Christie, Satwik Rajaram, Qinbo Zhou, Ellen Araj, Suneetha Chintalapati, Nirmish Singla, Jeffrey Cadeddu, Vitaly Margulis, Ivan Pedrosa, Dinesh Rakheja, Renee M. McKay, James Brugarolas, Payal Kapur   +13 more
doaj   +1 more source

Targeting of HIF2-driven cachexia in kidney cancer. [PDF]

Nat Med
Abu-Remaileh M, Stransky LA, Bhalerao N, Shirole NH, Jiang Q, Saad E, Machaalani M, Vigeant SM, Woldemichael H, Xu C, Lu J, Wei H, Liu Z, Sun W, Enomoto K, Choueiri TK, Pitarresi JR, Carr SA, Udeshi ND, Kaelin WG.   +19 more
europepmc   +1 more source

Development and evaluation of a light emitting diode endoscopic light source [PDF]

, 2012
Clancy, NT, Copner, N, Driscoll, P, Elson, DS, Excel, P, Hanna, G, Li, R, Rogers, K, Yandle, R   +8 more
core   +1 more source

Development of a Synthetic 3D Platform for Compartmentalized Kidney In Vitro Disease Modeling

Advanced Healthcare Materials, EarlyView.
A fully synthetic, compartmentalized 3D kidney disease model is introduced. The kidney model combines a PEG‐based hydrogel matrix with anisotropic, enzymatically degradable rod‐shaped microgels to spatially arrange a triple co‐culture of key renal epithelial, endothelial, and fibroblast cells.
Ninon Möhl, Daphne Bouwens, Johanna Abele, Aline Hans, Tanja Topic, Daniel Günther, Jitske Jansen, Rafael Kramann, Laura De Laporte   +8 more
wiley   +1 more source

RNF20 Suppresses Tumorigenesis by Inhibiting the SREBP1c-PTTG1 Axis in Kidney Cancer [PDF]

, 2017
Jae Ho Lee, Yong Geun Jeon, Kyoung Hwa Lee, Hye Won Lee, Jeu Park, Hagoon Jang, Minyong Kang, Hye Sun Lee, Hee Jin Cho, Do‐Hyun Nam, Cheol Kwak, Jae Bum Kim   +11 more
openalex   +1 more source

Enhancing Magnetic Hyperthermia at the Cell Membrane by Anchoring 92R‐Functionalized Magnetic Nanoparticles to Low‐Endocytic CCR9 Surface Receptors

Advanced Healthcare Materials, EarlyView.
We present a strategy to enhance magnetic hyperthermia therapy by modulating nanoparticle–cell interactions. Antibody‐functionalized magnetic nanoparticles targeting the low‐internalizing CCR9 receptor enable spatially controlled membrane anchoring, reducing aggregation and maximizing heat generation under alternating magnetic fields.
David Egea‐Benavente, Isabel Corraliza‐Gorjón, Thomas S. van Zanten, María del Puerto Morales, Leonor Kremer, Domingo F. Barber   +5 more
wiley   +1 more source

Doxorubicin‐Loaded Metal–Organic Framework for Ferroptosis‐Enhanced Chemotherapy Through Sustained Zn Release and Glutathione Peroxidase Downregulation

Advanced Healthcare Materials, EarlyView.
A robust zinc‐based metal–organic framework (ZnMOF) enables dual functions of doxorubicin delivery and sustained Zn2+ release to trigger ferroptosis‐enhnaced chemotherapy. DOX@ZnMOF effectively depletes intracellular glutathione, suppresses GPX4, and elevates reactive oxygen species, leading to efficient oxidative DNA damage and apoptosis.
Xin Ma, Chenghua Deng, Chaoyu Wang, Langston Tilman, Jinhong Li, Wenbin Lin   +5 more
wiley   +1 more source

A clinically validated AI framework for kidney cancer detection and characterization. [PDF]

Commun Med (Lond)
Petryshak B, Iljin M, Denissova A, Ariva J, Häide T, Lasn V, Reim M, Ivaniv I, Lillsaar T, Vilt H, Leht A, Karask A, Kiudma G, Käpp R, Salumaa P, Ilves P, Fishman D.   +16 more
europepmc   +1 more source

Assessing Barriers and Facilitators to Return to Work for Kidney Cancer Survivors: A 6-Month Longitudinal Study

Xiaoping Chen, Shuhong Chen, Guolong Chen, Xiyuan Liu, Huiming Lu, Man Xu, Mengxiao Jiang   +6 more
openalex   +1 more source