Results 281 to 290 of about 10,805,577 (430)

Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation

open access: yesAdvanced Science, EarlyView.
At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao   +14 more
wiley   +1 more source

The Gut-Kidney Axis in Chronic Kidney Diseases. [PDF]

open access: yesDiagnostics (Basel)
Tsuji K   +6 more
europepmc   +1 more source

Potassium homeostasis and management of dyskalemia in kidney diseases: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.

open access: yesKidney International, 2019
C. Clase   +14 more
semanticscholar   +1 more source

Functional Polarization of Liver Macrophages by Glyco Gold Nanoparticles

open access: yesAdvanced Science, EarlyView.
Macrophages play a critical role in several pathophysiological diseases by being involved in the activation of adaptive and innate immune responses. The repolarization of macrophages using gold nanoparticles functionalized with glycans for a more selective targeting toward a restorative phenotype leads to an amelioration of the events.
Jennifer Fernandez Alarcon   +25 more
wiley   +1 more source

Plasma proteome fingerprint in kidney diseases. [PDF]

open access: yesFront Mol Biosci
Nikolsky KS   +11 more
europepmc   +1 more source

Advancing the Identification of Bioactive Molecules and the Construction of a Synergistic Drug Delivery System in Combating Lung Injury

open access: yesAdvanced Science, EarlyView.
Traditional Chinese Medicine (TCM), while holistic and historically esteemed, faces challenges in “miracle cures” due to slow onset, long cycles, and difficulty controlling quality. This study obtains the active ingredients, glabridin (GLA) and puerarin (PUE), from Ge‐Gen Decoction (GGD), developing a safe and effective drug delivery system, GLA‐PUE ...
Jianhong Qi   +7 more
wiley   +1 more source

The microbial metabolite trimethylamine N-oxide and the kidney diseases. [PDF]

open access: yesFront Cell Infect Microbiol
Su JQ   +7 more
europepmc   +1 more source

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