Research-based versus clinical serum creatinine measurements and the association of acute kidney injury with subsequent kidney function: findings from the Chronic Renal Insufficiency Cohort study. [PDF]
, 2020 Background:Observational studies relying on clinically obtained data have shown that acute kidney injury (AKI) is linked to accelerated chronic kidney disease (CKD) progression.
Anderson, Amanda H +21 more
core
Improving the prognosis of patients with severely decreased glomerular filtration rate (CKD G4+): conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. [PDF]
, 2018 Patients with severely decreased glomerular filtration rate (GFR) (i.e., chronic kidney disease [CKD] G4+) are at increased risk for kidney failure, cardiovascular disease (CVD) events (including heart failure), and death.
Bansal, N +16 more
core +2 more sources
Advanced Healthcare Materials, EarlyView.This study presents a novel implantable drug delivery systemwith a biodegradable poly(caprolactone) membrane and compressed drug core forsustained release. These implantable devices deliver risperidone in vitro for 170 days and in vivo for 49 days in rats, showing promise for chronic conditions like schizophrenia.
Linlin Li +9 more
wiley +1 more source
Murine models of renal disease: Possibilities and problems in studies using mutant mice [PDF]
, 2000 The elucidation of the pathogenesis of human renal disease at the molecular level has been facilitated by the growing field of gene targeting and the development of mouse strains with single-gene deletions - the `knock-out' mice. Experimental nephrology,
Anders, Hans-Joachim +1 more
core +1 more source
Advanced Healthcare Materials, EarlyView.This perspective provides an overview of the growing interest in utilizing various gasotransmitters—small gaseous signaling molecules namely nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S)—for several therapeutic applications, with emphasis on the potential use of porous materials as carriers to provide safe and controlled local ...
Rosana V. Pinto +2 more
wiley +1 more source
Mild and moderate pre-dialysis chronic kidney disease is associated with increased coronary artery calcium. [PDF]
, 2011 BackgroundIt is increasingly evident that patients with chronic kidney disease (CKD) are more likely to die from heart disease than kidney failure. This study evaluated whether pre- dialysis CKD is an independent risk factor for coronary artery calcium ...
Budoff, Matthew J +4 more
core +2 more sources
Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy
Advanced Healthcare Materials, EarlyView.The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq +4 more
wiley +1 more source
Gambaran Kadar Kalsium Pada Pasien Penyakit Ginjal Kronik Stadium 5 Non Dialisis [PDF]
, 2016 : Calcium is the largest mineral in the body and is necessary in most biological processes. The body\u27s calcium levels are influenced by a variety of renal disorders, one of which is chronic kidney disease.
Idris, N. A. (Nur) +2 more
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Renal function, revascularization and risk [PDF]
, 2007 Peer reviewedAuthor ...
Croal, Bernard L. +2 more
core +1 more source
Advanced Healthcare Materials, EarlyView.This review highlights recent advances in microfluidic technologies for modeling human aging and age‐related diseases. It explores how organ‐on‐chip platforms improve physiological relevance, enable rejuvenation strategies, facilitate drug screening, detect senescent cells, and identify biomarkers.
Limor Zwi‐Dantsis +5 more
wiley +1 more source