Results 241 to 250 of about 5,063,263 (354)

PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe

Advanced Science, EarlyView.
This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao, Wenzhu Hu, Du Tang, Xinxin Liu, Kun Yu, Lixia Feng, Minyu Liao, Wang Lin, Wenqiang Zhu, Sanjay Rajagopalan, Xiaoli Lan, Jixin Zhong, Dao Wen Wang, Dawei Jiang, Xiaoquan Rao   +14 more
wiley   +1 more source

C-C motif receptor 2 is a core profibrotic factor in uremic cardiomyopathy

Disease Models & Mechanisms
Jing-Fu Bao, Bao-Cheng Guo, Jia-Ju Mo, Hongguo Zhu, Nan Jia, Fanfan Hou, Youhua Liu, Aiqing Li   +7 more
doaj   +1 more source

Association of Sphingolipids with All-Cause and Cardiovascular Death in Patients with Kidney Failure Treated with Maintenance Hemodialysis. [PDF]

J Am Soc Nephrol
Lidgard B, Hoofnagle AN, Zelnick LR, de Boer IH, Jensen P, Fretts AM, Siscovick DS, Siscovick DS, Umans JG, Bansal N, Lemaitre RN.   +10 more
europepmc   +1 more source

Highly Active Cu14 Cluster Precisely Activates Autophagy Inhibitor to Amplify Cuproptosis Immunotherapy

Advanced Science, EarlyView.
An atomically precise Cu14 cluster‐mediated bond scission reaction pioneers the amplification of the antitumor immune response via synergetic cuproptosis‐associated immunogenic cell death induction and in situ autophagy blockade. ABSTRACT Transition metal‐mediated cleavage mechanisms have emerged as an effective means to mitigate the off‐target ...
Qiu‐Xu Zang, Wei‐Tong Chen, Yu‐Ying Shen, Zhao‐Yang Wang, Kai Li, Xueli Zhao, Yanjuan Sang, Xiaoyuan Chen, Shuang‐Quan Zang   +8 more
wiley   +1 more source

Granulomatosis With Polyangiitis Presenting With Kidney Failure: A Case Report. [PDF]

Cureus
Haraziński K, Goliat W, Goliat-Mazurek M, Mazurek D, Jastrzebska I, Kaput A, Poreba K, Bobinski M, Czyszczon A, Tkaczyk A.   +9 more
europepmc   +1 more source

Hierarchical Targeting of TREM2+ Myeloid Cells via Acid‐Triggered OMVs Reprogram Immunosuppression and Suppress Osteolysis in Bone‐Metastatic TNBC

Advanced Science, EarlyView.
This study developed a hierarchical targeting nanoplatform, siTREM2@ETP‐PEOz‐OMVs, against triple‐negative breast cancer (TNBC) bone metastasis. It precisely delivers therapeutic siTREM2 to monocytes/macrophages within the metastatic niche. This intervention dually regulates cell fate: reprogramming immunosuppressive macrophages and inhibiting ...
Fanglu Chen, Yucheng Xue, Xiao Ma, Liang Chen, Zhenxuan Shao, Hangxiang Sun, Haochen Mou, Fangqian Wang, Zilong Li, Yechao Shen, Zhaoming Ye, Xiaohua Yu, Shengdong Wang   +12 more
wiley   +1 more source

Social Isolation and Loneliness in People Living With Chronic Kidney Disease and Kidney Failure: A Mixed Method Systematic Review. [PDF]

J Ren Care
McKie AL, Buttel PJ.
europepmc   +1 more source

Organ‐Specific and Conserved Regulatory Logic Orchestrates Gene Expression in the Embryonic Mesothelium

Advanced Science, EarlyView.
Integrated multi‐omic profiling maps the gene‐regulatory landscape of the coelomic mesothelium across heart, lung, and pancreas. A cardiac‐restricted regulatory program is uncovered in which TBX20 activates heart mesothelial (epicardial) cis‐regulatory elements, while MAF emerges as a conserved regulator of mesothelial identity.
Quang Minh Dang, Nicola Smart, Andia Nicole Redpath, Joaquim Miguel Vieira   +3 more
wiley   +1 more source

Rising mortality due to coexisting liver cirrhosis and kidney failure in the United States (1999-2023): A nationwide retrospective analysis. [PDF]

Medicine (Baltimore)
Faheem MSB, Hassan ST, Munir SU, Khan MI.   +3 more
europepmc   +1 more source