Results 91 to 100 of about 1,603,200 (360)

Proenkephalin A 119-159 (Penkid) Is an Early Biomarker of Septic Acute Kidney Injury: The Kidney in Sepsis and Septic Shock (Kid-SSS) Study [PDF]

, 2018
Introduction: Sepsis is the leading cause of acute kidney injury (AKI) in critically ill patients. The Kidney in Sepsis and Septic Shock (Kid-SSS) study evaluated the value of proenkephalin A 119-159 (penkid)—a sensitive biomarker of glomerular function,
Antonelli, M., Beishuizen, A., Bergmann, A., Chousterman, B. G., Constatin, J. -M., Damoisel, C., Deye, N., Di Somma, S., Dugernier, T., Francois, B., Gaudry, S., Gayat, E., Hartmann, O., Hollinger, A., Huberlant, V., Lascarrou, J. -B., Laterre, P. -F., Legrand, M., Marx, G., Mebazaa, A., Mercier, E., Oueslati, H., Pickkers, P., Sonneville, R., Struck, J., Wittebole, X.   +25 more
core   +2 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Nuclear medicine: investigation of renal function in small animal medicine [PDF]

, 2011
Kidney function investigations in veterinary medicine are traditionally based on blood analysis (blood urea nitrogen (BUN) and serum creatinine concentration) and / or urinalysis (urine specific gravity, protein-to-creatinine ratio or fractional ...
De Sadeleer, Carlos, Dobbeleir, André, Ham, Hamphrey, Peremans, Kathelijne, Slegers, Guido, van Bree, Henri, Vandermeulen, Eva, Vermeire, Simon   +7 more
core  

Kidney outcomes with SGLT2is for type 2 diabetes patients: does background treatment with metformin or RASis matter?

Frontiers in Endocrinology
IntroductionThere is a lack of real-world evidence regarding the impact of concomitant metformin and renin-angiotensin system inhibitors (RASis) on sodium-glucose cotransporter-2 inhibitor (SGLT2i)-associated kidney outcomes.
Kah Suan Chong, Yi-Hsin Chang, Yi-Hsin Chang, Meng-Hsuan Lin, Chien-Ning Hsu, Chien-Ning Hsu, Chi-Chuan Wang, Chi-Chuan Wang, Chi-Chuan Wang, Chih-Yuan Wang, Chih-Yuan Wang, Yun-Lin Huang, Fang-Ju Lin, Fang-Ju Lin, Fang-Ju Lin, Huang-Tz Ou, Huang-Tz Ou   +16 more
doaj   +1 more source

Role of CoQ10 on Some Biochemical and Histological Aspects of Kidney in Rats Exposed to Sodium Fluoride

Kufa Journal for Veterinary Medical Sciences, 2018
This experiment was aimed to investigate the role of CoQ10 to alleviating the functional alterations of kidney - induced by sodium fluoride (NaF) in male rats.
Baraa Najim Al-Okaily, Imtithal Ali Mohammed   +1 more
doaj   +1 more source

Oxidative stress and immune cell activation quantification in sepsis and non-sepsis critical care patients by neopterin/7,8-dihydroneopterin analysis

Pteridines, 2020
Introduction: Neopterin and 7,8-dihydroneopterin are used as biomarkers of oxidative stress and inflammation, but the effect of kidney function on these measurements has not been extensively explored.
Baxter-Parker Gregory, Gaddam Ravinder Reddy, Moltchanova Elena, Carr Anitra, Shaw Geoff, Chambers Stephen, Gieseg Steven P.   +6 more
doaj   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Diabetic kidney disease. new clinical and therapeutic issues. Joint position statement of the Italian Diabetes Society and the Italian Society of Nephrology on "the natural history of diabetic kidney disease and treatment of hyperglycemia in patients with type 2 diabetes and impaired renal function" [PDF]

, 2019
Recent epidemiological studies have disclosed heterogeneity in diabetic kidney disease (DKD). In addition to the classical albuminuric phenotype, two new phenotypes have emerged, i.e., “nonalbuminuric renal impairment” and “progressive renal decline ...
Barutta, Federica, De Nicola, Luca, Di Paolo, Salvatore, Gesualdo, Loreto, Natali, Andrea, Penno, Giuseppe, Pugliese, Giuseppe, Reboldi, Gianpaolo   +7 more
core   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

An Intact Kidney Slice Model to Investigate Vasa Recta Properties and Function in situ [PDF]

, 2012
Background: Medullary blood flow is via vasa recta capillaries, which possess contractile pericytes. In vitro studies using isolated descending vasa recta show that pericytes can constrict/dilate descending vasa recta when vasoactive substances are ...
Agmon Y, Armulik A, Bogle RG, Bratosin D, C. Crawford, C. Sprott, C.M. Peppiatt-Wildman, Crawford C, Cupples WA, Dahlstrom A, Dietrich HH, Dunn KW, Hall AM, Hamilton NB, Holliger C, Horiuchi T, Hughes S, J. Munday, Jans D, Kawamura H, L. Sawbridge, Landis EM, MacPhee PJ, Mattson DL, Mattson DL, O’Connor PM, Pallone TL, Pallone TL, Pallone TL, Pallone TL, Pallone TL, Park F, Patzak A, Peppiatt CM, Praetorius HA, R.J. Unwin, Rhinehart K, Rhinehart KL, Roman RJ, S.S.P. Wildman, Shepro D, Silldorff EP, Silldorff EP, Silldorff EP, Sprague RS, T. Desai, T. Kennedy-Lydon, Thiel G, Whitehouse T, Wu DM, Zhang Z, Zhang Z   +51 more
core   +2 more sources