Results 21 to 30 of about 12,427,323 (309)
Meta-analyses identify DNA methylation associated with kidney function and damage
Nature Communications, 2021 Chronic kidney disease is a major public health burden. Elevated urinary albumin-to-creatinine ratio is a measure of kidney damage, and used to diagnose and stage chronic kidney disease.
P. Schlosser +112 more
semanticscholar +1 more source
American Society of Nephrology. Clinical Journal, 2021 Visual Abstract Background and objectives The relationship of depressive symptoms with kidney function remains poorly investigated. We aimed to evaluate the prospective association between depressive symptoms and rapid decline in kidney function in ...
Zhuxian Zhang +12 more
semanticscholar +1 more source
Discovery and prioritization of variants and genes for kidney function in >1.2 million individuals
Nature Communications, 2020 Genes underneath signals from genome-wide association studies (GWAS) for kidney function are promising targets for functional studies, but prioritizing variants and genes is challenging.
Kira-Julia Stanzick +23 more
semanticscholar +1 more source
Reducing Kidney Function Decline in Patients With CKD: Core Curriculum 2021.
American Journal of Kidney Diseases, 2021 An estimated 8% to 16% of the world's population has chronic kidney disease, defined by low glomerular filtration rate or albuminuria. Progression of chronic kidney disease is associated with adverse outcomes, including incident kidney failure with ...
Teresa K. Chen +3 more
semanticscholar +1 more source
Associations of TNFR1 with kidney function outcomes by age, gender, and baseline kidney function status: Data from the Heart and Soul Study. [PDF]
, 2017 Tumor necrosis factor receptor type 1 (TNFR1) is associated with kidney disease and mortality risk in various populations [1], [2]. We evaluated associations of TNFR1 with mortality and mediators of this relationship in doi: 10.1016/j.atherosclerosis ...
Huang, Debbie +4 more
core +2 more sources
Repair of naturally occurring mismatches can induce mutations in flanking DNA
eLife, 2014 ‘Normal’ genomic DNA contains hundreds of mismatches that are generated daily by the spontaneous deamination of C (U/G) and methyl-C (T/G). Thus, a mutagenic effect of their repair could constitute a serious genetic burden.
Jia Chen +2 more
doaj +1 more source
An Analysis of Early Renal Transplant Protocol Biopsies - the High Incidence of Subclinical Tubulitis [PDF]
, 2001 To investigate the possibility that we have been underestimating the true incidence of acute rejection, we began to perform protocol biopsies after kidney transplantation. This analysis looks at the one-week biopsies. Between March 1 and October 1, 1999,
Burdick +16 more
core +1 more source
Cardiac and Kidney Benefits of Empagliflozin in Heart Failure Across the Spectrum of Kidney Function
Circulation, 2020 Supplemental Digital Content is available in the text. Background: In EMPEROR-Reduced (Empagliflozin Outcome Trial in Patients With Chronic Heart Failure With Reduced Ejection Fraction), empagliflozin reduced cardiovascular death or heart failure (HF ...
F. Zannad +12 more
semanticscholar +1 more source
BMC Nephrology, 2018 Background Immunoglobulin heavy-and-light-chain amyloidosis (AHL amyloidosis) is a newly established disease entity where both the immunoglobulin heavy-chain and light-chain compose amyloid fibrils. The immunoglobulins responsible for the amyloid fibrils
Shun Manabe +6 more
doaj +1 more source
Cystatin C: A Primer for Pharmacists
Pharmacy, 2020 Pharmacists are at the forefront of dosing and monitoring medications eliminated by or toxic to the kidney. To evaluate the effectiveness and safety of these medications, accurate measurement of kidney function is paramount.
Hilary R. Teaford +4 more
doaj +1 more source