Results 191 to 200 of about 343,283 (311)

MCV/Q, Medical College of Virginia Quarterly, Vol. 11 No. 4 [PDF]

, 1975

core   +1 more source

NPM1 Mediates mRNA Sorting into Extracellular Vesicles via Specific RNA Motif Binding and Phase Separation

Advanced Science, EarlyView.
NPM1 selectively sorts specific mRNAs into extracellular vesicles (EVs) by recognizing RNA motifs and forming phase‐separated condensates. These mRNA cargos—including EGFR—are then loaded via multivesicular bodies. This active sorting pathway, validated in EVs derived from both lung cancer cells and patient serum, reveals a specific mechanism for ...
Kaixiang Zhang, Gaoge Sun, Xiangzheng Liu, Shuai Zuo, Pengyuan Wang, Boxiao Zhan, Zhi John Lu, Hang Yin, Ying Zhang   +8 more
wiley   +1 more source

Childhood Malignant Kidney Neoplasm [PDF]

, 2020
openaire   +1 more source

Endogenous “Time Bomb” – Mislocalized Phospholipase A2 as a Critical Mediator of Ultra‐Rapid Mortality in Sepsis and Acute Lung Injury

Advanced Science, EarlyView.
Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang, Zhongxing Xu, Lin Wang, Xin Sui, Yuan Luo, Xiuli Zhao, Jun Yang, Yongan Wang   +7 more
wiley   +1 more source

Adolescent Renal Tumours: Diagnostic and Therapeutic Challenges in a Transitional Age Group-A Multidisciplinary Case Report Series from a Single Center. [PDF]

Oncol Res
Ruggiero A, Fuccillo F, Di Paola V, Romano A, Maurizi P, Talloa D, Foschi N, Russo P, Racioppi M, Mastrangelo S, Attinà G.   +10 more
europepmc   +1 more source

Hepatectomy in children. [PDF]

, 1982
Iwatsuki, S, Starzl, TE
core  

Time‐Controlled Refrigerated Stem Cell Therapy Mitigates Scleroderma Fibrosis via Modulation of Mitochondrial Autophagy and Gut Metabolism

Advanced Science, EarlyView.
This study established an RT‐MSCs‐based therapeutic approach for scleroderma in mice. RT‐MSCs attenuated fibrosis by regulating mitochondrial autophagy and restored gut microbiota homeostasis. Metabolomic analyses confirmed recovery of key metabolites, and RT‐MSCs demonstrated favorable lesion targeting and safety profiles.
Xue Xia, Chenfei Kong, Xiaoming Zhao, Naixu Shi, Jinlan Jiang, Ping Li   +5 more
wiley   +1 more source

Rapid Remodeling of the Human Gut Microbiome in Response to Short‐Term Animal Product Restriction and Associations with Host Molecular Phenotypes

Advanced Science, EarlyView.
A real‐world model of structured animal product restriction practiced for religious reasons reveals the dynamic adaptability of the human gut microbiome to dietary change and uncovers reductions in diversity and rare taxa loss. Integrated microbiome, metabolomic, and proteomic analyses uncover coordinated taxonomic and molecular shifts and identify ...
Christina Emmanouil, Maria Anezaki, Alexandros Simistiras, Stavros Glentis, Nikolaos Scarmeas, Pantelis Hatzis, Konstantinos Rouskas, Antigone S. Dimas   +7 more
wiley   +1 more source

Bilateral multifocal renal neuroendocrine carcinoma with synchronous pancreatic neuroendocrine carcinoma and adrenal lesion. [PDF]

J Surg Case Rep
Huynh QH, Nguyen CP, Nguyen XQ, Tong Thi MK, Nguyen SB.   +4 more
europepmc   +1 more source

Orthotopic liver transplantation [PDF]

, 1995
Gordon, RD, Starzl, TE, Van Thiel, DH
core