Results 271 to 280 of about 337,538 (347)

Integrative Omics Reveal Female‐Specific Benefits of p16+ Cell Clearance in Aging Mice

Advanced Science, EarlyView.
Aging causes accumulation of p16⁺ senescent cells that promote inflammation and dysfunction. Multi‐omics analyses reveal striking sex differences in senescent cell burden and clearance: females accumulate more p16⁺ cells, especially in the liver, and their removal rejuvenates molecular and functional profiles.
Yao Lin, Boshi Wang, Mengling Huang, Justina C. Wolters, Marco Demaria   +4 more
wiley   +1 more source

Risk Factors for West Nile Neuroinvasive Disease and Mortality in the US, 2013-2024.

JAMA Netw Open
Judson SD, Dowdy D.
europepmc   +1 more source

Socioeconomic disparities in urological cancers in iran: a systematic analysis for the Global Burden of Disease study 2019. [PDF]

BMC Public Health
Khajavi A, Hashemi FH, Khatami F, Ortakand RK, Noori M, Rahimnia R, Aghamir SMK.   +6 more
europepmc   +1 more source

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

A case of incidental renal pelvic basaloid squamous cell carcinoma. [PDF]

Medicine (Baltimore)
Li Z, Wang T, Wang Y, Su M, Ou Z, Hua J, Kui X.   +6 more
europepmc   +1 more source

Mapping the Tissue‐of‐Origins of Mesenchymal Stromal Cells in Injury Repair

Advanced Science, EarlyView.
This study maps mesenchymal stromal cells (MSCs) across multiple tissues, revealing that bone marrow–derived MSCs mobilize monocytes via CCL2 to promote systemic inflammation but do not migrate to distant organs to form fibrotic or tumor stroma. Instead, local MSCs dominate tissue remodeling, suggesting a “two‐hit” model linking systemic inflammation ...
Xinyu Thomas Tang, Yiming Liam Liu, Yidi Augenstern Du, Shan−Shan Wang, Bo O. Zhou   +4 more
wiley   +1 more source

Prevalence of skin cancers in kidney transplant recipients - one-center experience. [PDF]

Front Oncol
Kosko F, Dębska-Ślizień A, Imko-Walczuk B, Piesiaków ML, Biedunkiewicz B, Bułło-Piontecka B, Bzoma B, Chamienia A, Gołębiewska J, Konopa J, Król E, Liberek T, Lichodziejewska-Niemierko M, Lizakowski S, Rutkowski P, Tarasewicz A, Wczysla M, Heleniak Z.   +17 more
europepmc   +1 more source

Therapeutic Reprogramming of Glioblastoma Phenotypic States Using Multifunctional Heparin Nanoparticles

Advanced Science, EarlyView.
This study presents heparin‐derived nanoparticles (HP‐NPs) as a novel precision medicine platform that combines therapeutic and delivery functions. HP‐NPs target drug‐resistant glioblastoma stem cells, reprogramming them into a drug‐sensitive phenotype and significantly reducing tumor progression.
Vadim Le Joncour, Austin D. Evans, Camilla Karoliina Bergström, Vignesh Kumar Rangasami, Sumanta Samanta, Nithiyanandan Krishnan, Yuji Teramura, Bo Nilsson, Patricia Hedenqvist, Elin Manell, Jons Hilborn, Marianne‐Jensen Waern, Oommen P. Varghese, Pirjo Laakkonen, Oommen P. Oommen   +14 more
wiley   +1 more source

Idiopathic Atraumatic Renal Hemorrhage: Case Report. [PDF]

Clin Pract Cases Emerg Med
Ranson T, Ruddy G, Ostapowicz Z, Joyner L.   +3 more
europepmc   +1 more source