Results 141 to 150 of about 828,864 (314)
A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu +17 more
wiley +1 more source
Sonoselective Transfection of Glioma Endothelium
Delivering non‐viral, gene‐bearing nanoparticles with thiol‐decorated surfaces to gliomas with focused ultrasound yields transfection tropism for endothelial cells. From this platform, “sonoselective” transfection of glioma endothelium is achieved via incorporation of an endothelial cell‐specific promoter.
Anna C. Debski +8 more
wiley +1 more source
Self-Efficacy, Self-Care Behaviours and Quality of Life of Kidney Transplant Recipients
AIM: This paper is a report of an exploration of the effects of self- efficacy and different dimensions of self- management on quality of life among kidney transplant recipients.
WENG, LI-CHUEH;DAI, YU-TZU;HUANG, HSIU -LI;CHIANG, YANG-JEN +1 more
core
A 3D‑printed multilayer adhesive scaffold, firmly anchored to bone defects by simple finger pressing, suppresses micromotion and secures mechanical stability of the osteogenic niche. This stabilization likely contributes to the enhanced bone augmentation by fostering a pro‑regenerative mechano‐immune profile—characterized by M2‑like macrophage ...
Delu Zhao +7 more
wiley +1 more source
WCN24-2600 Tuberculosis in pediatric kidney transplant recipients: 35 years of experience
Vanesa Fauda +10 more
doaj +1 more source
Programmable Paracrine‐Mimetic Microneedle System for Temporal Regulation of Cardiac Repair
Temporal signaling is encoded into a programmable paracrine‐mimetic microneedle patch via tris(2,2'‐bipyridyl)dichlororuthenium(II) hexahydrate/sodium persulfate‐tuned hydrogel microparticles that deliver TGF‐β, IGF‐1, and VEGF over phase‐matched 7‐, 14‐, and 28‐day windows.
Yichen Dai +18 more
wiley +1 more source
Given that PEEK chest wall implants induce shear force at the soft tissue‐implant interface due to respiratory motion in the early in vivo post‐implantation stage. We confirmed that this mechanical stimulus triggers the PIEZO1/ITGB1/YAP1 signalling axis in L929 and the STAT6/p‐STAT6 pathway in RAW264.7, which in turn mediates adhesion and migration of ...
Rou Huang +14 more
wiley +1 more source
Does Time in a Day Alters Uroflowmetery: A Prospective Experience With Population of Nepal
Deepak Kumar Yadav +6 more
doaj +1 more source

