Results 301 to 310 of about 2,298,895 (410)

Brd4 BD1 Domain Antagonism of MS436 Preserves Blood‐Brain Barrier Integrity via Rnf43/β‐Catenin Signaling Pathway

open access: yesAdvanced Science, EarlyView.
MS436 competitively binds to the BD1 domain of Brd4, thereby suppressing Brd4 induced degradation of tight junction proteins via the Rnf43‐Fzd4‐β‐catenin signaling pathway. Consequently, this attenuation of degradation reduces blood‐brain barrier leakage, leading to an improved overall prognosis after stroke.
Chenxiao Li   +10 more
wiley   +1 more source

Neighborhood Ambient Air Pollution and Post-Transplant Outcomes in Older Kidney Transplant Recipients. [PDF]

open access: yesJ Am Geriatr Soc
Menon G   +11 more
europepmc   +1 more source

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

open access: yesAdvanced Science, EarlyView.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang   +7 more
wiley   +1 more source

One‐Step Coaxial 3D Printing of Pre‐Vascularized Skin Organoid Models with ADSC Microspheres for Enhanced Wound Healing

open access: yesAdvanced Science, EarlyView.
A multifunctional vascular bed platform is created using coaxial 3D printing, allowing the one‐step integration of organoid microspheres with perfusable vascular structures. This strategy enables rapid and functional vascularization of organoids to support tissue repair and vascularization, providing a scalable and translationally promising approach ...
Kunrui Wang   +10 more
wiley   +1 more source

Use of a pelvic kidney for living transplantation

open access: diamond, 2014
Soumaya Yaich   +6 more
openalex   +1 more source

FK506 IN CLINICAL ORGAN-TRANSPLANTATION [PDF]

open access: yes, 1991
ABUELMAGD, K   +14 more
core  

Integrin β3 Orchestrates Hepatic Steatosis via a Novel CD36‐Dependent Lipid Uptake Complex

open access: yesAdvanced Science, EarlyView.
In MASH, ITGB3 recruits LYN and drives its ubiquitin‐proteasomal degradation via phosphorylation. This relieves DHHC5 inhibition, enabling ITGB3/DHHC5/CD36 complex assembly to enhance CD36 palmitoylation and fatty acid uptake, thereby exacerbating disease. Targeting ITGB3 blocks this pathogenic axis and ameliorates MASH.
Ying Zhang   +13 more
wiley   +1 more source

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