Results 111 to 120 of about 32,146 (308)

Rapid development of vasopressin-induced hydroosmosis in kidney collecting tubules measured by a new fluorescence technique

Biophysical Journal, 1988
The pre-steady-state kinetics of the vasopressin-induced increase in collecting tubule osmotic water permeability (Pf) has been measured by a new fluorescence technique. Isolated cortical collecting tubules (CCT) from rabbit kidney were perfused with physiological buffers containing the impermeant fluorophores fluorescein sulfonate (FS) and ...
Kuwahara, M., Berry, C.A., Verkman, A.S.
openaire   +2 more sources

Asymmetric Cu─N─Ru Bridgedsite Nanozyme‐Loaded Injectable Thermogel Boosts Cuproptosis‐Like Death for Multidrug‐Resistant Urinary Tract Infections

Advanced Science, EarlyView.
To address multidrug‐resistant urinary tract infections (MDR‐UTIs), we developed Cu‐ZIF8‐Ru nanozyme featuring an asymmetric Cu─N─Ru catalytic site. This unique structure enhances multienzyme‐mimetic activity, eradicating resistant bacteria by inducing a cuproptosis‐like death pathway through intracellular Cu2+ accumulation and energy depletion.
Guanlin Li, Shike Zhang, Jinggong Liu, Xin Wang, Heng Wang, Hongcan Yang, Yuhao Zhou, Wen Liu, Hongxing Liu, Wenqi Wu   +9 more
wiley   +1 more source

A Subset of Pro‐inflammatory CXCL10+ LILRB2+ Macrophages Derives From Recipient Monocytes and Drives Renal Allograft Rejection

Advanced Science, EarlyView.
This study uncovers a recipient‐derived monocyte‐to‐macrophage trajectory that drives inflammation during kidney transplant rejection. Using over 150 000 single‐cell profiles and more than 850 biopsies, the authors identify CXCL10+ macrophages as key predictors of graft loss.
Alexis Varin, Jovanne Palvair, Lennie Messager, Jamal Bamoulid, Jasper Callemeyn, Mélanie Chaintreuil, Ludivine Dal Zuffo, Didier Ducloux, Imane Farhat, Mathieu Legendre, Laurent Martin, Florian Renosi, Xavier Roussel, Thibaut Vaulet, Maarten Naesens, Claire Tinel, Baptiste Lamarthée   +16 more
wiley   +1 more source

Disrupted glucocorticoid receptor cell signalling causes a ciliogenesis defect in the fetal mouse renal tubule

EMBO Reports
Primary cilia are cell signalling and environment sensing organelles and have important roles during embryogenesis and homeostasis. We demonstrate glucocorticoid signalling is essential for normal cilia formation in mouse and human renal tubules.
Kelly L Short, Jianshen Lao, Rachel Lam, Julie L M Moreau, Judy Ng, Mehran Piran, Alexander N Combes, Denny L Cottle, Timothy J Cole   +8 more
doaj   +1 more source

Neutrophil‐Mimetic Nanoscavengers Target the Inflammatory Microenvironment to Eliminate NETs/ROS and Immunomodulate cGAS‐STING Signaling in Septic AKI

Advanced Science, EarlyView.
Sepsis‐associated acute kidney injury is driven by oxidative stress, NETs overproduction, and dysregulated innate immunity. Here, we develop neutrophil‐mimetic nanoscavengers that integrate ROS‐scavenging Mn3O4 nanozymes with DNase‐1‐mediated NETs degradation to suppress cGAS‐STING signaling, reprogram macrophage polarization, and effectively alleviate
Zening Zhang, Chenxi Zhang, Ranran Luo, Qiuchi Wu, Pengchen Ren, Xinyu Liu, Yingying Luo, Zhongsheng Xu, Xiaojing He, Yun Liu   +9 more
wiley   +1 more source

Kidney [PDF]

, 2008
Histology blog entry for October 31, 2008 about the ...
Krause, William J., II, 1942-
core  

Pearl‐Like Bioinspired Coating Enables Regulation of Mg Degradation for Osteoporotic Bone Repair

Advanced Science, EarlyView.
In this study, inspired by pearl architecture, we developed a layered Ca–P “brick” and Fn‐mimetic peptide “mortar” coating on Mg alloys. The Ca–P layer moderates corrosion and offers mineral cues, while the peptide enhances adhesion and regulates immune‐vascular responses.
Siming Zhang, Tao Zhang, Yuan Chen, Nikolaos Kourkoumelis, Mo Chen, Jiale Dong, Zhenyu Li, Yanling Zhou, Ning Li, Chen Zhu, Xifu Shang, Jiaxiang Bai, Xianzuo Zhang   +12 more
wiley   +1 more source

MORPHO-CYTOLOGICAL STUDY OF THE HEAD, BODY AND CAUDAL PARTS OF KIDNEY IN JUVENILE ACIPENSER PERSICUS USING MODELING METHOD

‬‭Majallah-i ̒Ilmī-i Shīlāt-i Īrān, 2011
Morpho-cytological patterns of juvenile Acipenser persicus on basis of structure, size and distribution of kidney nephrons were studied. Sampling of head, body and caudal parts of the kidney in the fish aged 1 and 2 years were carried out (3 specimens of
S.Olaadi,
doaj  

Improvement effects of transplanting pancreatic islet that previously incubated with biomaterials on the diabetic nephropathy in STZ- diabetic rats

BMC Nephrology
Background Islet transplantation is an effective treatment for diabetes or even its complications. Aim of this study is to investigate efficacy of biomaterial treated islet transplantation on treating diabetic nephropathy. Methods Male rats were randomly
Marzieh Nemati, Zahra Hosseinzadeh, Fatemeh Nemati, Farhad Koohpeyma   +3 more
doaj   +1 more source

Metal‐Supramolecular Drug Delivery System Empowered Meningeal Lymphatic Vessels‐Bridged Intracranial‐Peripheral Dual Immune Modulation for Reversing Glioblastoma Immune Suppression

Advanced Science, EarlyView.
A novel metal‐supramolecular nanoplatform (FLM@VC) enables efficient brain delivery via meningeal lymphatic vessels (MLVs), bypassing the blood‐brain barrier (BBB) through subcutaneous administration. It reprograms tumor‐associated macrophages (TAMs) and remodels the MLVs to promote DC trafficking and CD8+ T cell activation.
Chenxi Zhang, Zhongsheng Xu, Xiaowen Xu, Zening Zhang, Ranran Luo, Pengchen Ren, Yingying Luo, Qiuchi Wu, Xinyu Liu, Guodong Liu, Xiaojing He, Yun Liu   +11 more
wiley   +1 more source