Results 211 to 220 of about 32,146 (308)

Sodium–glucose cotransporter 2 inhibitors for hypertension in cardiovascular–kidney–metabolic syndrome

Experimental Physiology, EarlyView.
Abstract The antihypertensive mechanism of sodium–glucose cotransporter 2 (SGLT2) inhibitors has been traditionally attributed to osmotic diuresis. However, emerging evidence reveals multifaceted mechanisms beyond diuresis, including regulation of the renin–angiotensin–aldosterone system, sympathetic nervous system suppression, ion homeostasis ...
Chunxiang Xu, Xingyu Qiu, Nan Xu, Gensheng Zhang, Enyin Lai, Liang Zhao   +5 more
wiley   +1 more source

The Influence of Sex and Hormones on Organelle Stress in Kidney Injury: Insights from Preclinical Models. [PDF]

Biology (Basel)
Salazar-Gonzalez H, Gutierrez-Mercado YK, Echavarria R.   +2 more
europepmc   +1 more source

One day of environment‐induced heat stress causes injury to the murine kidney

Experimental Physiology, EarlyView.
Abstract Environment‐induced heat stress (EIHS) results from sustained body temperature elevation owing to prolonged exposure to heat and humidity. We hypothesized that EIHS would cause kidney injury and cellular dysfunction. To test this hypothesis, female C57 mice were exposed to EIHS (n = 14; 37.6°C, 42.0% relative humidity) or thermoneutral (TN ...
Melissa Roths, Alyona Michael, Zachary J. Schlader, Joshua T. Selsby   +3 more
wiley   +1 more source

Piezo1 dictates K⁺ homeostasis through coordinated regulation of the ubiquitin ligase Kelch-like 3 in RBCs and the kidney. [PDF]

Proc Natl Acad Sci U S A
Ishizawa K, Kaseda K, Fujii W, Tomomitsu Y, Hirohama D, Yamazaki O, Kochi Y, Shibata S.   +7 more
europepmc   +1 more source

Early acclimatization to high altitude: Acid–base and fluid balance dynamics during the first 2 days at 3100 m

Experimental Physiology, EarlyView.
Abstract Immediate responses to hypoxia at high altitude are hyperventilation and successive respiratory alkalosis. Alkalosis, in turn, can affect cerebrospinal fluid pH and ventilatory control. The kidneys compensate metabolically for respiratory alkalosis.
Elisabeth Skalla, Benedikt Treml, Sasa Rajsic, Michael Schreinlechner, Zoran Bukumirić, Klaus Berek, Alexander Egger, Johann Knotzer, Martin Burtscher, Axel Kleinsasser   +9 more
wiley   +1 more source

Construction, evaluation, and applications of renal barrier-on-a-chip system. [PDF]

Bioact Mater
Naren T, Lv W, Aazmi A, Wang Y, Yu H, Lee JY, Yang H, Yu M, Jiang X, Yang H, Ma L.   +10 more
europepmc   +1 more source

Effect of foot immersion and neck cooling on renal, intestinal, immune and inflammatory markers in older adults exposed to extreme heat

Experimental Physiology, EarlyView.
Abstract Older adults with reduced thermoregulatory capabilities are increasingly at risk of heat‐related pathophysiological outcomes (e.g., acute kidney injury, heatstroke) due to increasingly frequent, prolonged and intense heatwaves. Foot immersion and neck cooling have been proposed as practical, non‐electrical cooling strategies for protecting ...
Thomas McCarthy, Ben J. Lee, James J. McCormick, Kelli E. King, Emma R. McCourt, Luana C. Main, Robert D. Meade, Glen P. Kenny   +7 more
wiley   +1 more source

Arp2/3-dependent regulation of ciliogenesis governs adaptive distal tubular epithelial cell states in kidney disease. [PDF]

Sci Adv
Rogg M, Weißer L, Maier JI, Sigle A, Helmstädter M, Stigler M, Sammarco A, Gräwe K, Andreev G, Kark C, Ramakrishnan SK, Özel C, Butt L, Arnold F, Bechtel-Walz W, Schilling O, Tanriver Y, Brinkkötter P, Grabbert M, Simons M, Werner M, Kretz O, Benzing T, Huber TB, Schell C.   +24 more
europepmc   +1 more source

Cellular microenvironment of erythropoietin‐producing cells in hypoxic and injured mouse kidneys

Experimental Physiology, EarlyView.
Abstract The main sources of circulating erythropoietin (Epo) in the adult are kidney Norn cells, a recently identified interstitial cell type capable of becoming renal Epo‐producing (REP) cells following a local decrease in tissue oxygenation. REP cells are restricted to small clusters in the corticomedullary border region, suggesting that their ...
Olga M. Lempke, Thomas Knöpfel, Stellor Nlandu Khodo, Roland H. Wenger   +3 more
wiley   +1 more source