Results 231 to 240 of about 32,146 (308)

Biomarkers of Drug‐Induced Kidney Injury: Use in Clinical Trials and Recent Examples of Impact on Drug Development

Clinical Pharmacology &Therapeutics, Volume 119, Issue 3, Page 608-617, March 2026.
This manuscript describes the scope of implementation and impact of a regulatory agency‐qualified panel of six urine biomarkers on drug development, the process for which was conducted and funded by the Critical Path Institute, the Foundation for the National Institutes of Health, and the United States Food and Drug Administration.
Tanja S. Zabka, Michael Lawton, Tom Chu, Gary S. Friedman, Katrina Peron, Stefan R. Sultana, Warren E. Glaab, Nicholas M. P. King   +7 more
wiley   +1 more source

Prenatal morphogenic and histogenic development of the kidney in rabbits (<i>Oryctolagus cuniculus</i>). [PDF]

Open Vet J
Aref M, Abd-Almotaleb NA, Elsheikh EH, Salem GA, Nassan MA, Elsheikh E.   +5 more
europepmc   +1 more source

Hepato‐Renal Protective Potential of Dimethyl Fumarate in Alloxan‐Induced Diabetic Mice Model by Modulating of Sirt1, Nrf2 and Inflammatory Genes Expressions

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 2, March 2026.
Hepato‐renal protective potential of DMF in alloxan‐induced diabetic mice model. ABSTRACT Aim Despite advances in diabetes treatments, the effects of this disease have not yet been adequately reversed or prevented in patients. Therefore, development of more effective medication‐assisted treatments in this field is needed.
Parisa Saberi‐Hasanabadi, Fatemeh Shaki, Mohammad Karami, Abouzar Bagheri, Mohammad Ranaee, Ramin Ataee   +5 more
wiley   +1 more source

TIMP2 promotes AKI-CKD transition by inducing tubular maladaptive repair and cell senescence via targeting Wnt/β-catenin signalling. [PDF]

Clin Transl Med
Xu D, Yu H, Pang J, Zhang X, Jiang J, Li Y, Peng Z.   +6 more
europepmc   +1 more source

尿中セマフォリン3Aは微小変化型ネフローゼ症候群の疾患活動性に関連する [PDF]

, 2017
Torii, Akiko
core  

Targeting the Nrf2/TGF‐β1/Smad Signaling Pathway: A Novel Strategy for Urolithin A to Alleviate Renal Fibrosis

Food Frontiers, Volume 7, Issue 2, March 2026.
The diagram of the mechanism of action by which UroA regulates RF. ABSTRACT The global prevalence and mortality rates associated with chronic kidney disease (CKD) have been on a continuous rise over recent decades. Renal fibrosis (RF) serves as a critical factor in the progression of CKD to end‐stage renal disease.
Xue Wu, Jiating Li, Yonghui Dong, Jia Li, Ji Bian, Chao Liu, Hongbo Zhang, Lin Han, Min Wang   +8 more
wiley   +1 more source

Clear cell renal cell carcinoma with collecting duct carcinoma transformation: a case report and review of the literature. [PDF]

BMC Urol
Liang M, Li L, Cao Y, Zhang K, Fu Q.
europepmc   +1 more source

Maintenance of Carnitine Homeostasis as a Therapeutic Strategy to Attenuate Cisplatin‐Induced Acute Kidney Injury

Food Frontiers, Volume 7, Issue 2, March 2026.
ABSTRACT Acute kidney injury (AKI) has emerged as a significant global public health concern due to its high morbidity and mortality rates. Cisplatin, a highly effective and widely used chemotherapeutic agent, is often limited in clinical application by its nephrotoxicity, particularly AKI.
Mingkang Zhang, Yazhi Wang, Xiujuan Wang, Yan Zhou, Yanrong Ma, Xin'an Wu   +5 more
wiley   +1 more source

Mitochondrial organization in the developing proximal tubule is controlled by LRRK2. [PDF]

Nat Commun
Khan M, Bond K, Grilli E, Cameron D, Zhao L, Sims-Lucas S, McMahon AP, Carroll TJ, Oxburgh L.   +8 more
europepmc   +1 more source