Results 1 to 10 of about 652,898 (168)

Purification and antibody-free ex-vivo expansion of peripheral blood-derived autologous natural killer cells: A Malaysian case series on patient safety and tolerability [PDF]

SAGE Open Medical Case Reports
Natural killer cells are the most researched and employed cells for immunotherapy, which have expanded from autologous immune-enhanced therapies to genetically enhanced cell therapies such as chimeric antigen receptors natural killer cells.
Ramesh Thevendran, Manickam Ravichandran, Seng Kong Tham   +2 more
doaj   +2 more sources

Uterine Natural Killer Cells

Frontiers in Immunology, 2019
Natural killer (NK) cells are members of a rapidly expanding family of innate lymphoid cells (ILCs). While most previously studied NK cells were derived from the mouse spleen and circulate in the blood, recently others and we found tissue-resident NK ...
Dorothy K. Sojka, Liping Yang, Wayne M. Yokoyama   +2 more
doaj   +2 more sources

A pan-cancer single-cell panorama of human natural killer cells.

Cell, 2023
Natural killer (NK) cells play indispensable roles in innate immune responses against tumor progression. To depict their phenotypic and functional diversities in the tumor microenvironment, we perform integrative single-cell RNA sequencing analyses on NK
Fei Tang, Jinhu Li, L. Qi, Dongfang Liu, Yufei Bo, Shishang Qin, Yuhui Miao, Kezhuo Yu, Wenhong Hou, Jiana Li, Jirun Peng, Z. Tian, Linnan Zhu, Hui Peng, Dongfang Wang, Zemin Zhang   +15 more
semanticscholar   +1 more source

Natural killer cells in antitumour adoptive cell immunotherapy

Nature Reviews. Cancer, 2022
Natural killer (NK) cells comprise a unique population of innate lymphoid cells endowed with intrinsic abilities to identify and eliminate virally infected cells and tumour cells.
Tamara J Laskowski, Alexander Biederstädt, K. Rezvani   +2 more
semanticscholar   +1 more source

Roles of natural killer cells in immunity to cancer, and applications to immunotherapy

Nature reviews. Immunology, 2022
Great strides have been made in recent years towards understanding the roles of natural killer (NK) cells in immunity to tumours and viruses. NK cells are cytotoxic innate lymphoid cells that produce inflammatory cytokines and chemokines.
Natalie Wolf, Djem U. Kissiov, D. Raulet
semanticscholar   +1 more source

Aging of the Immune System: Focus on Natural Killer Cells Phenotype and Functions

Cells, 2022
Aging is the greatest risk factor for nearly all major chronic diseases, including cardiovascular diseases, cancer, Alzheimer’s and other neurodegenerative diseases of aging.
Ashley Brauning, Michael Rae, G. Zhu, E. Fulton, T. Admasu, A. Stolzing, Amit Sharma   +6 more
semanticscholar   +1 more source

Use of CAR-Transduced Natural Killer Cells in CD19-Positive Lymphoid Tumors

New England Journal of Medicine, 2020
BACKGROUND Anti-CD19 chimeric antigen receptor (CAR) T-cell therapy has shown remarkable clinical efficacy in B-cell cancers. However, CAR T cells can induce substantial toxic effects, and the manufacture of the cells is complex.
E. Liu, D. Marin, P. Banerjee, H. Macapinlac, P. Thompson, R. Başar, Lucila Nassif kerbauy, Bethany J Overman, P. Thall, Mecit Kaplan, Vandana Nandivada, I. Kaur, A. N. Nunez Cortes, K. Cao, May Daher, C. Hosing, E. Cohen, P. Kebriaei, R. Mehta, S. Neelapu, Y. Nieto, Michael Wang, W. Wierda, M. Keating, Richard Champlin, E. Shpall, K. Rezvani   +26 more
semanticscholar   +1 more source

Natural killer cells in antiviral immunity

Nature reviews. Immunology, 2021
Natural killer (NK) cells play an important role in innate immune responses to viral infections. Here, we review recent insights into the role of NK cells in viral infections, with particular emphasis on human studies.
N. Björkström, B. Strunz, H. Ljunggren
semanticscholar   +1 more source

Natural killer cells: a promising immunotherapy for cancer

Journal of Translational Medicine, 2022
As a promising alternative platform for cellular immunotherapy, natural killer cells (NK) have recently gained attention as an important type of innate immune regulatory cell.
J. Chu, F. Gao, Mei-hua Yan, Shuang Zhao, Zheng Yan, B. Shi, Yanyan Liu   +6 more
semanticscholar   +1 more source

Reduced proportion and activity of natural killer cells in patients with Graves’ disease

European Journal of Inflammation, 2020
Natural killer cells not only play important roles in protecting against viral infection and cancer but also involved in the pathogenesis of Graves’ disease.
Qingqing Yang, Li Zhang, Cheng Guo, ChunJia Kou, Yu Long, Jianting Li, Hai-Qing Zhang   +6 more
doaj   +1 more source