Results 181 to 190 of about 8,017,385 (274)

SPG4 Hereditary Spastic Paraplegia: From Etiology to Therapy

Movement Disorders, EarlyView.
Abstract Hereditary spastic paraplegias (HSPs) comprise a heterogeneous group of heritable neurodegenerative disorders resulting from mutations in a wide variety of genes. HSP locomotor symptoms include lower limb weakness and spasticity that arise from progressive degeneration of corticospinal axons projecting from the motor cortex to the distal ...
Emanuela Piermarini, Peter W. Baas
wiley   +1 more source

Functional characterization of a pore-forming effector TseMt from the H4 type VI secretion system of <i>Pseudomonas aeruginosa</i>. [PDF]

mLife
Wu L, Liu Y, Huang R, Zhao Y, Liu J, An Y, Zhang Y, Wang X, Zheng H, Pei T, Liang X, Liu X, Zheng M, Liu R, Li Y, Qu J, Liu Y, Yang L, Zhang M, Dong T.   +19 more
europepmc   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

RNA methyltransferase CMTR-1 inhibition activates a GATA transcription factor-mediated protective immune response. [PDF]

PLoS Pathog
Ghosh A, Singh J.
europepmc   +1 more source

Redefining CHI3L1: Therapeutic Opportunities at the Crossroads of Immune Suppression and Disease Progression

Medicinal Research Reviews, EarlyView.
ABSTRACT Chitinase‐3‐like‐1 (CHI3L1, also known as YKL‐40) has been recognized as a biomarker of inflammation and tissue remodeling and has now emerged as a pseudoenzymatic immune checkpoint. Recent structural, immunological, and translational studies redefine it as an active regulator of immune suppression rather than a passive disease marker. Despite
Kirti Upmanyu, Saurabh Upadhyay, Moustafa T. Gabr   +2 more
wiley   +1 more source

Isometries of Spacetimes Without Observer Horizons. [PDF]

Commun Math Phys
García-Heveling L, Zeghib A.
europepmc   +1 more source

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source

Aphid-killing bacteria: diversity, origin, mechanisms and biocontrol potential. [PDF]

Front Microbiol
Berings L, Rojas-Preciado N, Poppelsdorf W, Van Hee S, Jacquemyn H, Lievens B.   +5 more
europepmc   +1 more source

Stanley Field Correspondence, 1912–1915

This correspondence collection is primarily comprised of letters by Stanley Field and Carl Akeley. The contents of the correspondence largely address the African buffalo diorama group and its installation at the Field ...
President. Field Museum of Natural History
core  

On Geometric Phase Model in the Theory of Curves With Myller Configuration

Mathematical Methods in the Applied Sciences, EarlyView.
ABSTRACT In this paper, we introduce a linearly polarized light wave in an optical fiber and rotation of the polarization plane through the Frenet‐type frame with Myller configuration. Since the geometric evaluation and interpretations of a polarized light wave are associated with geometric phase, a new type of geometric phase model has been ...
Zehra İşbilir, Bahar Doğan Yazıcı, Murat Tosun   +2 more
wiley   +1 more source