Results 181 to 190 of about 130,273 (231)

Minocycline and bone marrow–derived mononuclear cells as potential therapeutics for hereditary retinal degenerations

Acta Ophthalmologica, EarlyView.
Abstract Purpose To assess in Royal College of Surgeons (RCS) rats if the combination of two previously documented neuroprotective strategies: minocycline administration and bone marrow–derived mononuclear cells (BM‐MNCs) intravitreal transplantation, offers enhanced neuroprotection compared with each treatment alone.
Alba Videla‐Ristol, Ana Martínez‐Vacas, David García‐Bernal, Manuel Vidal‐Sanz, María Paz Villegas‐Pérez, Diego García‐Ayuso, Johnny Di Pierdomenico   +6 more
wiley   +1 more source

Recent Advances in Endolysin Engineering. [PDF]

Antibiotics (Basel)
Aitken M, Abeysekera G, Billington C, Dobson RCJ.   +3 more
europepmc   +1 more source

A vaccination programme combining a live attenuated Salmonella Typhimurium and an autogenous inactivated Salmonella Enteritidis vaccine confers protection and reduces ovarian colonisation with the Salmonella Enteritidis isolate 7A, PT12

Australian Veterinary Journal, EarlyView.
Salmonella enterica serovar Enteritidis (SE) can colonise chicken ovaries and contaminate eggs, posing a global risk of human gastroenteritis, often linked to raw or undercooked eggs. Control options for SE outbreaks in Australia are limited; autogenous SE vaccines are commonly used, while live attenuated Salmonella Typhimurium (ST) vaccines are ...
JA Quinteros, TB Wilson, A Anwar, T Scott, P Shil, AH Noormohammadi, G Underwood, PC Scott   +7 more
wiley   +1 more source

Real-time bioluminescence imaging of mycobacteria with Akaluc: a novel method for monitoring drug efficacy. [PDF]

Sci Rep
Islam MS, Takeishi A, Tateishi Y, Nishiyama A, Ozeki Y, Yoshida Y, Shaban AK, Annoura T, Iwano S, Fukuhara T, Matsumoto S.   +10 more
europepmc   +1 more source

In vivo CAR therapies: Turning the patient into their own CAR factory. [PDF]

Hemasphere
Vilcot F, Brugère CA, Fuentealba J, Houot R.   +3 more
europepmc   +1 more source

New biosensors and transgenic mice for multiplex cGMP imaging

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a versatile second messenger that is important for human (patho‐)physiology and pharmacotherapy. Live‐cell imaging of cGMP with biosensors allows to elucidate its spatiotemporal dynamics in real time under close‐to‐native conditions. However, to monitor two separate cGMP pools or cGMP/cAMP
Markus Wolters, Martin Thunemann, Barbara Birk, Susanne Feil, Viacheslav O. Nikolaev, Moritz Lehners, Robert Feil   +6 more
wiley   +1 more source

Complement inhibition by a unique cluster of immunomodulatory outer surface proteins of Borrelia recurrentis. [PDF]

Nat Commun
Röttgerding F, Reyer F, Gerlach E, Amborn M, Duschek N, Schultze TG, Fingerle V, Roome CM, Stumpf M, Becker K, Rahlfs S, Przyborski JM, Kraiczy P, Fritz-Wolf K.   +13 more
europepmc   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

In vivo CAR-cell therapy: current challenges and emerging therapeutic advances. [PDF]

Mol Biomed
Yang YM, Bao B, Cao YH, Yao J, Ding YF, Hu YY, Fan F, Zhao JL.   +7 more
europepmc   +1 more source

PLGA‐particle‐based vaccine induces SARS‐CoV‐2‐specific antibody and T‐cell responses

British Journal of Pharmacology, EarlyView.
A novel coronavirus disease 2019 (COVID‐19) vaccine encapsulating recombinant severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) spike receptor binding domain (RBD) with the double stranded RNA (dsRNA) analogue Riboxxim induces robust systemic and respiratory T‐ and B‐cell responses in mice.
Dennis Horvath, Katharina Inholz, Dennis Mink, Alicia Madel, Julia Koerner, Reinhold Horlacher, Michael Basler   +6 more
wiley   +1 more source