Results 161 to 170 of about 2,793,586 (269)

Molecular Functions and Drug Prediction of MMP1 and TGFBR2 in Nasopharyngeal Carcinoma

Journal of Clinical Laboratory Analysis, EarlyView.
MMP1 and TGFBR2 were validated by machine learning and external datasets as the candidate genes. Dexamethasone showed strong binding affinity to MMP1 (−7.72 kcal/mol) and TGFBR2 (−7.27 kcal/mol) in docking studies. Knockdown of MMP1 repressed the malignant phenotypes of NPC cells.
Feng Wang, Binbin Ge, Ming Li, Xiaochun Xia, Fuming Zhang, Pengqin Xu   +5 more
wiley   +1 more source

Phenotypic heterogeneity optimizes trade-offs during adaptive deployment of the type VI secretion system. [PDF]

PLoS Biol
Taillefer B, Schattenberg F, Doan T, Müller S, Cascales E.   +4 more
europepmc   +1 more source

Artificial intelligence‐assisted nanozyme design for medical and environmental applications

Journal of Intelligent Medicine, EarlyView.
AI‐assisted nanozyme design integrates cross‐source data and machine learning to enable predictive structure‐activity relationships, accelerating intelligent diagnostics, precision therapeutics, and environmental surveillance. Abstract Nanozymes, a class of nanomaterials with intrinsic enzyme‐like catalytic activities, have emerged as promising ...
Xiaolin Guo, Hao Zhang, Zihan Zhao, Qingshan Liu, Jiayi Liu, Jiang Huang, Changlong Liu, Xiaoyu Mu   +7 more
wiley   +1 more source

A note on integrated local energy decay estimates for spherically symmetric black hole spacetimes. [PDF]

Math Ann
Holzegel G, Mavrogiannis G, Ruiz RV.
europepmc   +1 more source

Insect communities of late Pleistocene steppe–tundra and Holocene boreal forest ecosystems in central Yukon Territory, Canada

Journal of Quaternary Science, EarlyView.
ABSTRACT Subfossil insect communities from the Quartz Creek site provide a detailed record of both Late Pleistocene steppe–tundra and Holocene boreal forest ecosystems in central Yukon Territory, Canada. Fifteen Pleistocene assemblages (marine isotope stages [MIS] 4 to 2) are dominated by steppe–tundra and dry‐tundra taxa, particularly the weevils ...
Scott L. Cocker, Svetlana Kuzmina, Nick Schafstall, Michael A. Monzon, Duane G. Froese   +4 more
wiley   +1 more source

CD5⁺ dendritic cell robots mediated in situ immunocyte activation. [PDF]

Sci Adv
Li C, Zhang W, Chen X, Ding S, Wang L, Wang Q, Yu S, Zhu Q, Niu J, Cui Y, Sun M, Zhao J, Li T.   +12 more
europepmc   +1 more source

Purely Coclosed G2‐Structures on Nilmanifolds—II

Mathematische Nachrichten, EarlyView.
ABSTRACT This paper completes the classification of seven‐dimensional nilpotent Lie groups endowed with a left‐invariant purely coclosed G2$\text{G}_2$‐structure, initiated in Bazzoni et al. [Mathematische Nachrichten 296 no. 6 (2023): 2236–2257], the authors provided the classification of decomposable seven‐dimensional nilpotent Lie groups and of the ...
Giovanni Bazzoni, Giorgia Petracci
wiley   +1 more source

Entropic Dynamics Approach to Quantum Electrodynamics. [PDF]

Entropy (Basel)
Caticha A.
europepmc   +1 more source

Artificial Intelligence for Identifying Tumor‐Reactive CD8+ T Cells: Biological Principles, Computational Advances, and Future Directions

Med Research, EarlyView.
This review details a three‐stage paradigm shift for tumor‐reactive CD8+ T‐cell identification: decoding transcriptomic states, deciphering clonal functional efficacy, and molecular‐level therapeutic TCR design. Addressing translational hurdles and generative AI “scientific blind spots”—such as missing catch bonds—we present a visionary roadmap.
Chao Yang, Yingying Sun, Yan Zhang, Yifen Shi, Zhiwen Shi   +4 more
wiley   +1 more source

Portable experimental hut tents (PEHTs): a conceptual framework for improved malaria vector control decision-making with a review of fixed experimental hut sites in Africa. [PDF]

Parasit Vectors
Oxborough RM, Wickramasinghe T, Gopakumar N, Fong M, Sabtiu ARM, Qualls WA, Diclaro JW, Stamey J, Xue RD, Tiruha Y, Churcher TS, Park S, Afrane Y, Messenger LA.   +13 more
europepmc   +1 more source