Results 221 to 230 of about 2,793,586 (269)

Nanobodies as next‐generation targeting platforms: From discovery technologies to translational biomedicine

VIEW, EarlyView.
Nanobodies, derived from the variable domains of camelid heavy‐chain‐only antibodies, have emerged as transformative biomedical tools due to their nanoscale size, exceptional stability, and unique capacity to recognize cryptic epitopes. This review provides a comprehensive overview of the field, outlining the structural and biochemical features of ...
Zhenrui Ye, Xianyang Li, Meixiao Zhan
wiley   +1 more source

Single- and dual-target CAR-T cells targeting HBsAg and GPC3 to balance safety and antitumor efficacy in HBV-positive hepatocellular carcinoma. [PDF]

iScience
Chen Q, Chen Z, Xu D, Wang H, Hu A, Hu Z, Gao P, Li H, Li Y, Sun L, Gao K, Hou H, Di J, Chai K, Zhu B, Zhang Q, Wang G, Xu W, Han Z, Zheng J, Liu Y.   +20 more
europepmc   +1 more source

Nanomedicine applications in lymphoma: Advancing precision diagnostics, targeted therapeutics, and prospective developments

VIEW, EarlyView.
Lymphoma is a group of blood cancers that can appear in lymph nodes, blood, bone marrow, spleen, liver, or the central nervous system, which makes drug delivery and disease monitoring difficult. This review summarizes how nanomedicine technologies may improve targeted treatment and imaging, while carefully separating approved or guideline‐supported ...
Mohd Ahmar Rauf, Yara Mashal, Afeefa Rao, Nasar Ata, Arun K. Iyer, Farhan Shah   +5 more
wiley   +1 more source

Oncostatin-M ligand-based CAR-T therapy displays robust anti-tumor activity against osteosarcoma. [PDF]

BMC Med
Feinberg D, Uppin V, Eid S, Fritz C, Hitomi M, Radhakrishnan A, Klatt K, Choi SH, Myers JT, Bhatt A, Stearns D, Pateva I, Burke ZDC, Huang AY, Schwartz GK, Parameswaran R.   +15 more
europepmc   +1 more source

Adaptive harvesting of two trophic levels stabilises predator–prey dynamics. Simulations with Eurasian lynx and European roe deer

Wildlife Biology, EarlyView.
Europe has seen the recovery of many species of wild herbivores, which are now widespread across much of the continent. In addition, large carnivores are also recolonising many European countries. Most ungulates are managed through hunting, but natural predation can also have a significant influence in many areas.
Cécile A. E. Carpentier, Marco Heurich, Olivier Devineau, Olivier Gimenez, John D. C. Linnell   +4 more
wiley   +1 more source

Generalised killing spinors on three-dimensional Lie groups. [PDF]

Manuscr Math
Artacho D.
europepmc   +1 more source

Estimating crippling loss from hunting with multistate models: a case study on northern bobwhites

Wildlife Biology, EarlyView.
Hunting as a recreational pursuit provides an important ecosystem service worldwide. Harvest management plays a vital role in regulating wildlife take to ensure long‐term population sustainability and meet value‐based objectives (e.g. hunter satisfaction). However, managers rarely have complete control or observability of harvest mortality.
Amanda S. Cramer, Justin A. Rectenwald, William B. Lewis, Michael A. Hazelbaker, Alexander L. Jackson, Holly K. Lott, Geoff Beane, D. Clay Sisson, Melanie R. Kunkel, Nicole M. Nemeth, James A. Martin   +10 more
wiley   +1 more source

Prioritizing areas for wolf management in Austria by modelling potential habitat and depredation risk

Wildlife Biology, EarlyView.
The recovery of wolf populations across Europe has reignited human–wildlife conflicts, particularly in countries such as Austria, where wolves have been absent for more than a century. Livestock depredation remains one of the primary sources of tension, and effective management requires a solid spatial basis for planning.
Florian Kunz, Luca Fuchs, Matthias Amon, Klaus Hackländer, Jörg Fabian Knufinke, Jennifer Hatlauf   +5 more
wiley   +1 more source

Recognition of ErbB Family Dimers by the EGF-like Domain of NRG1alpha and Beta: Implications for Ligand-Based CAR Therapy. [PDF]

Int J Mol Sci
Novikov A, Naumchik A, Banerji R, Greenshpan Y, Waidha K, Bhattacharya B, Elkabets M, Radinsky O, Porgador A.   +8 more
europepmc   +1 more source

Graph neural network‐based attack prediction for communication‐based train control systems

CAAI Transactions on Intelligence Technology, EarlyView.
Abstract The Advanced Persistent Threats (APTs) have emerged as one of the key security challenges to industrial control systems. APTs are complex multi‐step attacks, and they are naturally diverse and complex. Therefore, it is important to comprehend the behaviour of APT attackers and anticipate the upcoming attack actions.
Junyi Zhao, Tao Tang, Bing Bu, Qichang Li   +3 more
wiley   +1 more source