Results 61 to 70 of about 3,126,307 (290)

Kim-barne Wadawurrung Tabayl: You are in Wadawurrung Country

open access: yes, 2023
Kim-barne Wadawurrung Tabayl: You are in Wadawurrung ...
Gareth Powell (13460430)   +1 more
core  

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

open access: yesMolecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim   +7 more
wiley   +1 more source

An improved GM(1,1) model based on weighted MSE and optimal weighted background value and its application

open access: yesScientific Reports
GM(1,1) model is widely used because it does not require a large number of samples and has a low computational complexity and no limitation of statistical assumptions.
Won-Chol Yang   +4 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

A PROCESS IMPROVEMENT MODEL BASED ON QUANTITATIVE MANAGEMENT FOR SMALL AND MEDIUM SIZED SOFTWARE ORGANIZATIONS [PDF]

open access: yesICTACT Journal on Management Studies
Nowadays, software process improvement (SPI) is a way for strengthening the productivity and the competitiveness even for small and medium sized organizations, not to mention for large sized ones.
Il Nam Mun   +3 more
doaj   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

open access: yesFEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki   +5 more
wiley   +1 more source

Fully viable DHOST bounce with extra scalar

open access: yesJournal of High Energy Physics
In this paper we construct a class of Degenerate Higher-Order Scalar-Tensor (DHOST) theories with an extra scalar field, which admits viable solutions of bouncing universe satisfying the following requirements: (i) absence of Belinski-Khalatnikov ...
Ok Song An   +4 more
doaj   +1 more source

HYBRID AOA AND TDOA MEASUREMENTS BASED MULTI-SOURCE LOCALIZATION USING THE GENETIC ALGORITHM [PDF]

open access: yesICTACT Journal on Communication Technology
The multi-source localization in sensor array networks is a major challenge for radar and sonar. Recent advances in array signal processing techniques and hardware technologies have resulted in a significant increase in the accuracy of angle of arrival ...
Un-Il Kim   +3 more
doaj   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

open access: yesFEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen   +8 more
wiley   +1 more source

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