Results 221 to 230 of about 3,771,587 (392)

Structural dynamics of mixed-subunit CaMKIIα/β heterododecamers filmed by high-speed AFM. [PDF]

Nat Commun
Matsushima K, Sumikama T, Suzuki T, Ito M, Nagasawa Y, Sumino A, Flechsig H, Ogoshi T, Umeda K, Kodera N, Murakoshi H, Shibata M.   +11 more
europepmc   +1 more source

Metabolic Responses to Arsenite Exposure Regulated through Histidine Kinases PhoR and AioS in Agrobacterium tumefaciens 5A [PDF]

, 2020
Rachel A. Rawle, Monika Tokmina‐Lukaszewska, Zunji Shi, Yoon‐Suk Kang, Brian Tripet, Dang Fang, Gejiao Wang, Timothy R. McDermott, Valérie Copié, Brian Bothner   +9 more
openalex   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

<i>E. coli</i> chemosensing accuracy is not limited by stochastic molecule arrivals. [PDF]

Nat Phys
Mattingly HH, Kamino K, Ong J, Kottou R, Emonet T, Machta BB.   +5 more
europepmc   +1 more source

The selectivity of protein kinase inhibitors: a further update.

Biochemical Journal, 2007
J. Bain, Lorna Plater, M. Elliott, N. Shpiro, J. Hastie, Hilary, Mclauchlan, Iva Klevernic, Simon Arthur, D. Alessi, P. Cohen   +10 more
semanticscholar   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Spontaneous symbiotic reprogramming of plant roots triggered by receptor-like kinases

, 2014
Martina Katharina Ried, Meritxell Antolín‐Llovera, Martin Parniske   +2 more
openalex   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

A Novel Tyrosine Kinase Axis in Innate Immune Signaling. [PDF]

Viruses
Das S, Sengupta P, Veleeparambil M, Chattopadhyay S.   +3 more
europepmc   +1 more source

The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells

, 2015
Bernard Khor, John D Gagnon, Gautam Goel, Marly I. Roche, Kara L. Conway, Khoa Tran, Leslie N. Aldrich, Thomas B. Sundberg, Alison M. Paterson, Scott Mordecai, David Dombkowski, Melanie Schirmer, Pauline H. Tan, Atul K. Bhan, Rahul Roychoudhuri, Nicholas P. Restifo, John J. O’Shea, Benjamin D. Medoff, Alykhan F. Shamji, Stuart L. Schreiber, Arlene H. Sharpe, Stanley Y. Shaw, Ramnik J. Xavier   +22 more
openalex   +2 more sources