Results 251 to 260 of about 3,771,587 (392)

The Discovery of Abl Kinase ATPase Activity and ItsImplications in the Development of Straightforward Assays

Diego Magno Martins (22606499), Philipe Oliveira Fernandes (22606502), Lucas Almeida Vieira (22606505), Tiago Antônio Brandão (22606508), Adolfo Henrique Moraes (22606511)   +4 more
openalex   +1 more source

MAP kinase kinase kinase 12 (MAP3K12; DLK) [PDF]

Science-Business eXchange, 2013
openaire   +1 more source

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

Science, 2011
Daniel F Egan, D. Shackelford, M. Mihaylova, Sara Gelino, Rebecca A. Kohnz, William B. Mair, Debbie S. Vasquez, Aashish Joshi, Dana M. Gwinn, Rebecca C. Taylor, J. Asara, J. Fitzpatrick, A. Dillin, B. Viollet, M. Kundu, M. Hansen, R. Shaw   +16 more
semanticscholar   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Spinning-Induced Exertional Rhabdomyolysis Without Acute Kidney Injury. [PDF]

Clin Case Rep
Gutierrez YV, Shaju R, Sepulveda A, Rivera J, Ahmad A.   +4 more
europepmc   +1 more source

Targeting the phosphoinositide 3-kinase pathway in cancer

Nature reviews. Drug discovery, 2009
Pixu Liu, Hailing Cheng, T. Roberts, Jean J. Zhao   +3 more
semanticscholar   +1 more source

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

Signaling pathways in systemic lupus erythematosus and therapeutic implications. [PDF]

Front Immunol
Balogh L, Kovács VG, Nagy G, Németh T.
europepmc   +1 more source

High-resolution cryo-EM of the human CDK-activating kinase for structure-based drug design [PDF]

Victoria I. Cushing, Fujiet Koh, Junjie Feng, Kaste Jurgaityte, Alexander Bondke, Sebastian H. B. Kroll, Marion Barbazanges, Bodo Scheiper, Ash Bahl, Anthony G. M. Barrett, Simak Ali, Abhay Kotecha, Basil J. Greber   +12 more
openalex   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source