Results 311 to 320 of about 2,849,925 (342)

Multi-omics protein signaling networks identify sex-specific therapeutic candidates in lung adenocarcinoma. [PDF]

Biol Sex Differ
Chen C, Saha E, Fischer J, Ben Guebila M, Fanfani V, Shutta KH, Padi M, Glass K, DeMeo DL, Lopes-Ramos CM, Quackenbush J.   +10 more
europepmc   +1 more source

Decoding Molecular Network Dynamics in Cells: Advances in Multiplexed Live Imaging of Fluorescent Biosensors. [PDF]

Biosensors (Basel)
Chen Q, Xu Y, Wu JW, Yang JM, Huang CH.
europepmc   +1 more source

Mechanism of MEK1 phosphorylation by the N-terminal acidic motif-mediated asymmetric BRAF dimer

Kondo Y, Notbohm J, Navas Camacho I, Nagy-Davidescu G, Mason T, Mühle J, Standfuss J, Perica T.   +7 more
europepmc   +1 more source

Neuroblastoma-associated ALK variants have distinct cellular and biochemical activities

Wulf AM, Lutimba S, Cameron D, Desjardins J, Shaw TJ, Rossetti L, Mansour MA, Liu KJ.   +7 more
europepmc   +1 more source

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MAP kinase kinase kinases and innate immunity

Trends in Immunology, 2006
Toll-like receptors, which respond to invariant microbial molecules, and receptors for the proinflammatory cytokines tumour necrosis factor and interleukin-1 are crucial for initiation and regulation of innate immune responses. These receptors activate each of the major mitogen-activated protein (MAP) kinase subtypes, extracellular signal-regulated ...
Sören Beinke, Antony Symons, Steven C. Ley   +2 more
openaire   +3 more sources

The Mnks: MAP kinase-interacting kinases (MAP kinase signal-integrating kinases)

Frontiers in Bioscience, 2008
The human MAP kinase-interacting kinases (or MAP kinase signal-integrating kinases), Mnks, comprise a group of four proteins derived from two genes (Gene symbols: MKNK1 and MKNK2) by alternative splicing. Mnk1a/b differ at their C-termini, as do Mnk2a/2b: in each case, the a-form possesses a longer C-terminal region than the b-form, which lacks the MAP
Buxade, Maria, Parra-Palau, Josep L., Proud, Christopher G.   +2 more
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MAP kinase kinase kinase, MAP kinase kinase and MAP kinase

Current Opinion in Genetics & Development, 1994
Signal transduction pathways that respond to external signals through the MAP kinase family of protein kinases are involved in diverse responses in eukaryotic cells. MAP kinases are one element in a series of kinases that serve to connect the plasma membrane with cytoplasmic and nuclear events. MAP kinases have the unusual feature that their activation
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Plant MAP kinase kinase kinases structure, classification and evolution

Gene, 1999
The increasing number of reports describing plant MAP kinase signalling components reflects the cardinal role that MAP kinase pathways are likely to play during plant growth and development. Relationship and structural analyses of plant MAP kinase kinase kinase related cDNAs and genes established, on one hand, the PMEKKs, which may be distinguished ...
Stefan Jouannic, Martin Kreis, Anne-Sophie Leprince, A. Hamal, James Tregear, Yves Henry   +5 more
openaire   +3 more sources

Kinase dysfunction and kinase inhibitors

Veterinary Dermatology, 2013
With recent advances in molecular biology, abnormalities in cancer cells that contribute to dysregulation of cell survival and proliferation are being characterized with greater precision. Through this process, key abnormalities in cancer cells involving proteins that regulate signal transduction, migration, mitosis and other critical processes have ...
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Phosphoinositide kinases

Current Opinion in Cell Biology, 1990
Recently, a number of cDNA clones with homology to the catalytic subunit of phosphoinositide 3-kinase have been identified, and the sequence of the first cDNA clone encoding a phosphatidylinositol 4-phosphate 5-kinase has been published. Use of both dominant-negative mutants of phosphoinositide 3-kinase and the inhibitors wortmannin and LY294002 has ...
C L, Carpenter, L C, Cantley
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