Results 281 to 290 of about 276,702 (351)

Beyond Docking: A Multi‐Tier Computational Pipeline for USP7 Inhibitor Optimization

ChemMedChem, Accepted Article.
Ubiquitin‐specific protease 7 (USP7) is a key deubiquitinating enzyme involved in tumor suppression, DNA repair, and epigenetic regulation. Given its critical role in cancer progression, USP7 has emerged as an attractive therapeutic target. In this study, we employed a multi‐tier computational approach, integrating ligand‐based virtual screening ...
Serdar Durdagi, Ehsan Sayyah, Muhammet Eren Ulug, Serdar Durdağı   +3 more
wiley   +1 more source

Simulating the in vivo tumor microenvironment-advances in building a vascularized model of hepatocellular carcinoma through 3D bioprinting. [PDF]

Hepatobiliary Surg Nutr
Du L, Yang H.
europepmc   +1 more source

Harnessing Viral Proteases for Cellular and Molecular Engineering

Chemistry–Methods, EarlyView.
Engineered viral proteases (VIPs) provide programmable control of protein function with high specificity and low toxicity. Integrated with chemogenetic and optogenetic modules, these VIP systems enable logic gate manipulation for targeted regulation of cell signaling, gene expression, protein secretion, and degradation, thereby offering versatile ...
Mingguang Cui, Tien‐Hung Lan, Yubin Zhou   +2 more
wiley   +1 more source

Association of genetically proxied cancer-targeted drugs with cardiovascular diseases through Mendelian randomization analysis. [PDF]

J Transl Med
Fang C, Liu X, Yu C, Li S, Liu X, Qiu S, Liang H, Ou C, Xiu J.   +8 more
europepmc   +1 more source

Inorganic Metal Nanoparticles in Reproductive Biology: Applications, Toxicities and Future Prospects

ChemPlusChem, EarlyView.
Metal nanoparticles (MNPs) have shown great promise in the livestock industry such as semen collection, nano‐purification, cryopreservation, sex sorting, bioimaging, drug and gene delivery. However, reproductive toxicity induced by MNP has adverse effects on various sexual functions including poor sperm parameters, testicular damage, ovary injury, and ...
Sangita Kundu, Wilfried A. Kues, Christoph Rehbock, Stephan Barcikowski   +3 more
wiley   +1 more source

Roles of PEG10 in cancer and neurodegenerative disorder (Review). [PDF]

Oncol Rep
Mou D, Wu S, Chen Y, Wang Y, Dai Y, Tang M, Teng X, Bai S, Bai X.   +8 more
europepmc   +1 more source

Genetic Analysis of Melanoma Types Using Japanese Genomic Database. [PDF]

Laryngoscope
Matsumoto H, Nagano H, Kyutoku T, Yamashita M.   +3 more
europepmc   +1 more source

Molecular basis for the phosphorylation of bacterial tyrosine kinase Wzc. [PDF]

Nat Commun
Yang Y, Batista M, Clarke BR, Agyare-Tabbi MR, Song H, Kuehfuss NM, Le Bas A, Robinson CV, Whitfield C, Stansfeld PJ, Naismith JH, Liu J.   +11 more
europepmc   +1 more source

β‐Catenin localization in the ctenophore Mnemiopsis leidyi suggests an ancestral role in cell adhesion and nuclear function

Developmental Dynamics, EarlyView.
Abstract Background The emergence of multicellularity in animals marks a pivotal evolutionary event, which was likely enabled by molecular innovations in the way cells adhere and communicate with one another. β‐Catenin is significant to this transition due to its dual role as both a structural component in the cadherin–catenin complex and as a ...
Brian M. Walters, Lucas J. Guttieres, Mayline Goëb, Stanley J. Marjenberg, Mark Q. Martindale, Athula H. Wikramanayake   +5 more
wiley   +1 more source

Engineering aptamer-directed phosphatase recruiting chimeras: a strategy for modulating receptor function and overcoming drug resistance. [PDF]

Nat Commun
Zhou Z, Liu Y, Wang Y, Jiang H, Chen T, Zhu Y, Fu T, Li J.   +7 more
europepmc   +1 more source