Results 141 to 150 of about 1,477,881 (298)

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Proteomics and phosphoproteomics of human colorectal cancer cells lacking a specific kinase activity reveal kinase-specific compensatory responses. [PDF]

Anim Cells Syst (Seoul)
Han B, Lim HJ, Kim SJ, Shin J, Kim HH, Kim KH, Nam CH, Kim KP.   +7 more
europepmc   +1 more source

DNA damage sensing by the ATM and ATR kinases.

Cold Spring Harbor Perspectives in Biology, 2013
Alexandre Maréchal, L. Zou
semanticscholar   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Natural products as kinase inhibitors in lung cancer: molecular mechanisms, therapeutic potential, and clinical trials. [PDF]

Front Pharmacol
Wali AF, Talath S, Babiker R, El-Tanani M, Rangraze IR, Ibraheem W, Al Aldhaheri Y, Satyam SM, El-Tanani Y.   +8 more
europepmc   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

An update on regulation of the polymodal TRPV4 channel by protein phosphorylation. [PDF]

Channels (Austin)
Parthasarathy A, Zhang DX.
europepmc   +1 more source

Chk1 and Chk2 kinases in checkpoint control and cancer.

Cancer Cell, 2003
J. Bartek, J. Lukas
semanticscholar   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Phosphorylation of a conserved aspartate in the catalytic site of eukaryotic elongation factor 2 kinase. [PDF]

Protein Sci
Piserchio A, Isiorho EA, Abzalimov R, Dalby KN, Ghose R.   +4 more
europepmc   +1 more source