Results 121 to 130 of about 21,289 (213)

Heavy water inhibits DNA double-strand break repairs and disturbs cellular transcription, presumably via quantum-level mechanisms of kinetic isotope effects on hydrolytic enzyme reactions. [PDF]

PLoS One
Yasuda T, Nakajima N, Ogi T, Yanaka T, Tanaka I, Gotoh T, Kagawa W, Sugasawa K, Tajima K.   +8 more
europepmc   +1 more source

Conformational Switch in the Alpha‐Synuclein C‐Terminal Domain Directs Its Fibril Polymorphs

Chemistry – A European Journal, EarlyView.
The conformational state of the C‐terminal domain determines the fibril morphology of full‐length wild‐type alpha‐synuclein: high C‐terminus flexibility promotes twisted fibrils, while partial C‐terminal folding drives the assembly of rod‐like fibrils.
Cesar Aguirre, Yohei Miyanoiri, Masatomo So, Hajime Tamaki, Takahiro Maruno, Junko Doi, Nan Wang, Keiichi Yamaguchi, Kichitaro Nakajima, Yu Yamamori, Hiroko Inoura, Chi‐Jing Choong, Keita Kakuda, Takahiro Ajiki, Yasuyoshi Kimura, Tatsuhiko Ozono, Kousuke Baba, Seiichi Nagano, Yoshitaka Nagai, Hirotsugu Ogi, Susumu Uchiyama, Yoh Matsuki, Kentaro Tomii, Yuji Goto, Kensuke Ikenaka, Hideki Mochizuki   +25 more
wiley   +1 more source

Mechanism of Ampicillin Hydrolysis by New Delhi Metallo-β-Lactamase 1: Insight From QM/MM MP2 Calculation. [PDF]

J Comput Chem
Lai R, Li H.
europepmc   +1 more source

Studies on enzymatic oxidation of 3',4'-dihydroxy-l-phenylalanine to dopachrome using kinetic isotope effect methods. [PDF]

J Radioanal Nucl Chem, 2014
Byszewska W, Kańska M.
europepmc   +1 more source

In Situ X‐ray Diffraction Studies on the Reduction of U3O8 by Various Reducing Agents

Chemistry – A European Journal, EarlyView.
The reduction of U₃O₈ by hydrogen, PVDF, and CaH₂ is investigated using continuous in situ X‐ray diffraction. Phase transitions, oxygen loss, and intermediate structures are analyzed. The study elucidates how different reducing environments influence reaction pathways and final products, offering new insight into uranium oxide chemistry relevant to ...
Marvin Michak, Frank‐Constantin Ideker, Holger Kohlmann   +2 more
wiley   +1 more source

Amino Acid Complexation Fractionates Nickel Isotopes: Implications for Tracing Nickel Cycling in the Environment. [PDF]

Environ Sci Technol Lett
Selden CR, Schilling K, Basu A, Timm J, Saunders N, Yee N.   +5 more
europepmc   +1 more source

Fluorescent Deferoxamine Complexes of Cu(II) and Zr(IV): Insights in the Development of Dual Imaging Probes

Chemistry – A European Journal, EarlyView.
The insertion of a fluorescent coumarin unit by using a lysine‐based linker on deferoxamine leads to a chelating agent (DFOKC), whose Cu(II) and Zr(IV) complexes can be used for both optical imaging and positron emission tomography. DFOKC shows increased binding ability for Cu(II) and Zr(II) and improved tumor cell internalization via pinocytosis ...
Yschtar Tecla Simonini Steiner, Virginia Zizi, Monica Mangoni, Patrizia Nardini, Daniele Bani, Andrea Bencini, Antonio Bianchi, Matteo Savastano, Giammarco Maria Romano   +8 more
wiley   +1 more source

Oxidative Dehydrogenation of N‐Heteroaromatic Alkyl Alcohols and Amines Facilitated by Dearomative Tautomerization

Chemistry – A European Journal, Accepted Article.
The oxidation of alcohols, amines, and halides is a fundamental transformation in organic chemistry with significant applications in the synthesis of fine chemicals, pharmaceuticals, and natural products. Here we show that a broad variety of N‐heteroarenes bearing hydroxymethyl, aminomethyl, or halomethyl groups are oxidatively dehydrogenated to their ...
Omid Ghasemloo, Carson L. Hasselbrink, Douglas D. Cardona, Brenton DeBoef, Dugan Hayes   +4 more
wiley   +1 more source

Discrimination Factor of Sulphur Stable Isotope Ratios Between Pregnant Fin Whales and Their Foetuses. [PDF]

Rapid Commun Mass Spectrom
Ruiz-Sagalés M, Borrell A, Aguilar A.
europepmc   +1 more source

Intramolecular PCET of α‐Keto Acids: Synthesis of Trifluoromethyl Ketones via Ketyl Radicals

Chemistry – A European Journal, EarlyView.
Decarboxylation of α‐keto acids have conventionally served as simple building blocks for the generation of nucleophilic acyl radicals. Herein, we demonstrate a distinct approach for this substrate class, showcasing the generation of ketyl radicals through a proton‐coupled electron transfer (PCET) mechanism.
Rifat N. Nabi, Kimberly A. Jarquin, Anupam Karmakar, Kyle E. Brunner, Daniel K. Kim   +4 more
wiley   +1 more source