Results 31 to 40 of about 21,289 (213)

Computational Modeling and Experimental Approaches for Understanding the Mechanisms of [FeFe]‐Hydrogenase

Advanced Science, EarlyView.
A comprehensive understanding of hydrogenases' structures and catalytic mechanisms is crucial to replicate and exceed their performance. Computational modeling has proven to be a powerful tool for elucidating the reduction chemistry of [FeFe]‐hydrogenases. This review overviews recent computational and experimental efforts, focusing on DFT calculations
Chang‐Ah Kim, Jiabin Wu, Jun Zhu, Huaiguang Li, Zhihai Ke   +4 more
wiley   +1 more source

Development of Carbon‐11 Labeled Pyrimidine Derivatives as Novel Positron Emission Tomography (PET) Agents Enabling Brain Sigma‐1 Receptor Imaging

Advanced Science, EarlyView.
Novel carbon‐11 labeled pyrimidine derivatives are developed as PET imaging probes for visualizing sigma‐1 receptors in the brain. [11C]CNY‐01 demonstrates superior brain uptake and binding specificity in both rodents and non‐human primates. The study reveals decreased sigma‐1 receptor expression in Alzheimer's disease, offering a promising tool for ...
Ping Bai, Ashley Gomm, Chi‐Hyeon Yoo, Prasenjit Mondal, Fleur Marie Lobo, Hui Meng, Yanting Zhou, Weiyao Xie, Hsiao‐Ying Wey, Rudolph E. Tanzi, Can Zhang, Changning Wang, Yu Lan   +12 more
wiley   +1 more source

PSMD14 Stabilizes SLC7A11 to Ameliorate Glucocorticoid‐Induced Osteoporosis by Suppressing Osteocyte Ferroptosis

Advanced Science, EarlyView.
Glucocorticoid‐induced osteoporosis (GIOP) triggers osteocyte ferroptosis via SLC7A11 degradation. PSMD14 stabilizes SLC7A11 by counteracting glucocorticoid‐driven ubiquitination, preserving cystine uptake and glutathione synthesis. AAV‐mediated PSMD14 delivery or its agonist Pantethine rescues osteocyte survival and bone loss in GIOP mice.
Yifeng Shi, Qian Tang, Sunren Sheng, Hongyi Jiang, Chen Jin, Chencheng Zhou, Chenglong Xie, Lin Zheng, Di Zhang, Hui Xu, Cong Xu, Haiwei Ma, Guangheng Xiang, Wenfei Ni, Xiaoyun Pan, Lei Yang, Huazi Xu, Yu Qian, Aimin Wu, Xiangyang Wang, Gang Zheng   +20 more
wiley   +1 more source

Improving the Luminescence and Stability of Carbon-Centered Radicals by Kinetic Isotope Effect. [PDF]

Molecules, 2023
Ma Z, Zhang L, Cui Z, Ai X.
europepmc   +1 more source

Discovery, Herbicidal Activity and Biosynthesis of a Novel Natural Tetramic Acid from Alternaria Species

Advanced Science, EarlyView.
The biosynthetic mechanism of novel natural tetramic acid S‐TeA in Alternaria alternata is elucidated. Threonine acts as a precursor for 2‐amino‐3‐methylhexanoic acid (AMHA) synthesis via eight key enzymes from the branched‐chain amino acid biosynthetic pathway in the mitochondrion, wherein three unique enzymes (IPMS, IPMDH, and ISMD) play critical ...
He Wang, Yanjing Guo, Qing Liu, Jing Zhang, Qianlong Zhang, Mingying Yang, Qizhen Chen, Sheng Qiang, Bernal E. Valverde, Shiguo Chen   +9 more
wiley   +1 more source

A General Strategy for C(sp3)─H Bond Etherification via Quinoline Derivative‐Mediated Electrolysis

Advanced Science, EarlyView.
A quinoline‐based mediator is introduced for the electrochemical etherification of C(sp3)─H bonds, enabling the process with minimal dependence on substrate electronic properties. The reaction demonstrates compatibility with various C─H bonds, including tertiary benzylic C─H bonds and unactivated C(sp3)─H bonds.
Yousen Xu, Hao Wu, ChenXi Zhu, Minjun Tu, Lei Zhang   +4 more
wiley   +1 more source

A Kinetic Isotope Effect in the Formation of Lanthanide Phosphate Nanocrystals. [PDF]

J Am Chem Soc, 2022
Schwartz G, Hananel U, Avram L, Goldbourt A, Markovich G.   +4 more
europepmc   +1 more source

Local Charge Density Enhancement Strategy in Nitrogen‐rich Covalent Organic Framework for Boosted Iodine Removal From Water

Advanced Science, EarlyView.
The covalent organic framework, phen‐TPA, is designed for efficient iodine removal from aqueous solutions, featuring optimized iodine‐binding N‐sites. It shows the fastest iodine removal kinetics for I2 and the highest capacity for I3−. Large‐scale flow‐through tests demonstrate its effective separation of I2 and I3− in high‐salinity environments ...
Yue Ma, Jinjiao Pan, Huazhen Rong, Lu Liu, Yilei Zhang, Xuewen Cao, Jiacheng Zhang, Tao Liu, Ning Wang, Yihui Yuan   +9 more
wiley   +1 more source

Inconsistent kinetic isotope effect in ammonia charge exchange reaction measured in a Coulomb crystal and in a selected-ion flow tube. [PDF]

Nat Commun, 2022
Ard SG, Viggiano AA, Sweeny BC, Long B, Shuman NS.   +4 more
europepmc   +1 more source

The Function of Photocatalytic Performance and Carrier Separation Efficiency Tuned by Doping Content in Homogeneous Photocatalysts

Advanced Science, EarlyView.
A doping model of homogeneous photocatalysts of TiO2 is constructed to directly show the mapping relationship between carrier separation efficiency and photocatalytic performance. TRPL, KPFM, fs‐TAS measurements further quantify the carrier dynamics process. The photocatalytic performance of this series samples is dominated by the optimal conditions of
Chunxia Wen, Xinyue Ni, Mei Han, Yue Yu, Chuanqiang Liu, Yuan Zhang, Beining Zheng, Shouhua Feng   +7 more
wiley   +1 more source