Results 71 to 80 of about 21,289 (213)

Deuterium Kinetic Isotope Effect Studies of a Potential in Vivo Metabolic Trapping Agent for Monoamine Oxidase B. [PDF]

ACS Chem Neurosci, 2018
Drake LR, Brooks AF, Mufarreh AJ, Pham JM, Koeppe RA, Shao X, Scott PJH, Kilbourn MR.   +7 more
europepmc   +1 more source

Stereoretentive Intramolecular Glycosyl Cross-Coupling: Development, Scope, and Kinetic Isotope Effect Study. [PDF]

Org Lett, 2018
Yi D, Zhu F, Walczak MA.
europepmc   +1 more source

Theoretical calculations of kinetic isotope effects

, 2000
Treating the activated complex for unimolecular dissociation as uncoupled fragments simplifies the calculation of transition-state frequencies in the quasi-equilibrium-theory formulation of an isotopic rate-constant ratio. The general method is applied to the specific case of the intramolecular kinetic isotope effect in decarboxylation of malonic acid.
openaire   +4 more sources

Electrochemical Detection of Deuterium Kinetic Isotope Effect on Extracellular Electron Transport in Shewanella oneidensis MR-1. [PDF]

J Vis Exp, 2018
Tokunou Y, Hashimoto K, Okamoto A.
europepmc   +1 more source

Excited‐State Basicity Diverts the Site‐Selectivity of Aromatic Deuteration: Application to the Late‐Stage Labeling of Pharmaceuticals

Angewandte Chemie International Edition, EarlyView.
We present a metal‐free method for aromatic deuterium labeling via photoexcitation in deuterated HFIP. This approach leverages the enhanced basicity of excited‐state aromatics to achieve selective hydrogen isotope exchange at challenging positions. Demonstrated on complex drug molecules, this efficient strategy provides a valuable tool for isotope ...
Eva Rivera‐Chao, Javier Corpas, Giovanni Lonardi, Volker Derdau, Alessandro Ruffoni, Daniele Leonori   +5 more
wiley   +1 more source

Sensitive and Accurate ¹³C Kinetic Isotope Effect Measurements Enabled by Polarization Transfer. [PDF]

J Am Chem Soc, 2017
Kwan EE, Park Y, Besser HA, Anderson TL, Jacobsen EN.   +4 more
europepmc   +1 more source

Coordinative Ring‐Opening Polymerization of Limonene Carbamate towards Phosgene‐ and Isocyanate‐Free Polyurethane

Angewandte Chemie International Edition, Accepted Article.
This study presents a phosgene‐ and isocyanate‐free route for the synthesis of polyurethanes using (R)‐limonene as a bio‐based starting material. The synthesis of the cyclic limonene‐based carbamate monomer LU is achieved in high yields using dimethyl carbonate as a sustainable, less hazardous phosgene surrogate and is verified by NMR, SC‐XRD, ESI‐MS ...
Jonas Futter, Leon Ferdinand Richter, Stefanie Hörl, Bernhard Rieger, Moritz Kränzlein   +4 more
wiley   +1 more source

Kinetic Isotope Effect in the Unfolding of a Protein Secondary Structure: Calculations for Beta-Sheet Polyglycine Dimers as a Model. [PDF]

Biomolecules
Yanshin AO, Kiselev VG, Baklanov AV.
europepmc   +1 more source

Intramolecular Hydrogen Atom Transfer in Aminyl Radical at Room Temperature with Large Kinetic Isotope Effect. [PDF]

J Am Chem Soc, 2017
Wang Y, Olankitwanit A, Rajca S, Rajca A.   +3 more
europepmc   +1 more source

Mechanochemical Strategies Applied to the Late‐Stage Modifications of Pharmaceutically Active Compounds

Angewandte Chemie International Edition, Accepted Article.
This review explores the potential of mechanochemistry in the late‐stage modification of active pharmaceutical ingredients (APIs), offering a comprehensive analysis of methods designed to transform structurally complex molecular scaffolds. By examining the scope, efficiency, and mechanistic aspects of these approaches, the review highlights protocols ...
Johanna Templ, Lars Borchardt
wiley   +1 more source