Results 51 to 60 of about 14,531,298 (306)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Assessment of the ellipsoidal-statistical Bhatnagar-Gross-Krook model for force-driven Poiseuille flows [PDF]
, 2013 We investigate the accuracy of the ellipsoidal-statistical Bhatnagar–Gross–Krook (ES-BGK) kinetic model for planar force-driven Poiseuille flows. Our numerical simulations are conducted using the deterministic discrete velocity method, for Knudsen ...
Zhang, Yonghao +3 more
core +4 more sources
工程科学学报, 2021 The inclusions at the defects of tinplate originated from the entrainment of the mold flux, but their composition differed significantly from that of the mold flux.
Ju-jin WANG +5 more
doaj +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Indonesian Journal of Chemistry, 2023 The production of highly efficient and reusable adsorbents that can be used in pigment treatment has been of great scientific interest. Metallic organic frameworks (MOFs) are considered a new type of material with extremely diverse structures and can be ...
Kim Ngan Thi Tran +4 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Highly Efficient Adsorption of Phenylethanoid Glycosides on Mesoporous Carbon
Frontiers in Chemistry, 2019 PhGs are the major active compounds of Cistanche tubulosa, and it is extremely desirable for obtaining high purification of PhGs by adsorption from their extracts.
Helin Xu +4 more
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Кинетическая модель взаимодействия частицы и пузырька во флотационном комплексе франклит – доломит – кальцит [PDF]
, 2007 On the basis of the exposed conformities to the la w the kinetic model of flotation which takes into account the power barrier of framework of water and energy of surface-tension on the section of three phases in a flotation complex a frankolite ...
Олейник, Т. А. +1 more
core
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source